☆ 4.6 Article

Photochemically induced chloromethylation/cyclization of benzimidazole derivatives with CCl4/CHCl3

ORGANIC & BIOMOLECULAR CHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Organic

Catalyst-Controlled Nickel-Catalyzed Intramolecular endo-Selective C-H Cyclization of Benzimidazoles with Alkenes

Zi-Jian Liu et al.

Summary: Compared with exo-selective C-H cyclization, the endo-selective C-H cyclization of benzimidazoles with alkenes has been a challenge. Previous methods relied on substrate-controlled approaches, limiting the complexity of the products. This study reports a catalyst-controlled method using a bulky N-heterocyclic carbene ligand and tBuOK baseenabled Ni-Al bimetallic catalyst to facilitate endo-cyclization.

ORGANIC LETTERS (2023)

添加到收藏夹

Article Chemistry, Applied

Radical Polychloromethylation/Cyclization of Unactivated Alkenes: Access to Polychloromethyl-Substituted Ring-Fused Quinazolinones

Han Liu et al.

Summary: A metal-free radical di- and trichloromethylation/cyclization of unactivated alkenes was developed using commercially available dichloromethane and chloroform as di- and trichloromethyl sources. Various di- and trichloromethylated pyrrolo- and piperidino-quinazolinones were obtained in good yields. The dichloromethylated product can be further transformed into a spiro[cyclopropane-1,3'-pyrrolo[2,1-b]quinazolin]-9'(2'H)-one using KOH.

ADVANCED SYNTHESIS & CATALYSIS (2022)

添加到收藏夹

Article Chemistry, Organic

Visible light promoted polyhalomethylation of alkenes: alkylation and cyclization

Tong-Lin Wang et al.

Summary: The visible light promoted carbochloromethylation reaction reported in this study utilizes common and inexpensive reagents to synthesize various trihalomethyl substituted allylic acid esters and indolone derivatives. The mild reaction conditions and broad substrate scope make it a promising method for organic synthesis.

ORGANIC CHEMISTRY FRONTIERS (2022)

添加到收藏夹

Article Chemistry, Organic

Free Radical Cascade Carbochloromethylations of Activated Alkenes

Zhi-Wei Zhao et al.

Summary: Free radical carbochloromethylation reactions of ortho-cyanoarylacrylamides and N-(arylsulfonyl)acrylamides have been developed using simple alkyl chlorides as the chloromethyl source. These transformations exhibit wide functional group compatibility and provide efficient methods for constructing polychloromethyl-substituted quinoline-2,4-diones and alpha-aryl-beta-polychloromethylated amides.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Organic

Photocatalyst-, metal- and additive-free regioselective radical cascade sulfonylation/cyclization of benzimidazole derivatives with sulfonyl chlorides induced by visible light

Bin Sun et al.

Summary: An environmentally friendly and practical method for the regioselective radical cascade sulfonylation/cyclization of unactivated alkenes under visible-light-triggered conditions has been developed. The method allows for the synthesis of polycyclic benzimidazoles containing the sulfone group. Control experiments confirmed the involvement of radical pathways and the initial generation of a sulfonyl radical center through the self-homolysis of sulfonyl chloride. This protocol offers a wide substrate scope, high atom economy, excellent regioselectivity, and ease of scalability.

ORGANIC CHEMISTRY FRONTIERS (2022)

添加到收藏夹

Article Chemistry, Organic

Sustainable Cascades to Difluoroalkylated Polycyclic Imidazoles

Sheng-Nan Lin et al.

Summary: A visible light promoted difluoroalkylated cascade reaction of imidazoles and alkenes was reported, providing highly functionalized polycyclic imidazoles. The method allows for a direct radical cyclization of imidazoles with alkenes using BrCF2R as radical sources, with up to 95% isolated yield under mild conditions. Radical-trapping and light-on/off experiments suggested a photocatalytic radical mechanism.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Organic

Direct Alkoxycarbonylation of Heteroarenes via Cu-Mediated Trichloromethylation and In Situ Alcoholysis

Wenkun Luo et al.

ORGANIC LETTERS (2020)

添加到收藏夹

Article Chemistry, Organic

Radical-Cation Vinylcyclopropane Rearrangements by TiO2 Photocatalysis

Naoya Maeta et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs

Marco Di Stefano et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Synthetic Approaches for C-N Bonds by TiO2 Photocatalysis

Dongge Ma et al.

FRONTIERS IN CHEMISTRY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

TiO2 Photocatalysis for Transfer Hydrogenation

Dongge Ma et al.

MOLECULES (2019)

添加到收藏夹

Article Chemistry, Organic

Visible-Light-Promoted Tandem Annulation of N-(o-Ethynylaryl)acrylamides with CH2Cl2

Yu Liu et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Copper-catalyzed formylation of alkenyl C-H bonds using BrCHCl2 as a stoichiometric formylating reagent

Yan Bao et al.

CHEMICAL SCIENCE (2018)

添加到收藏夹

Article Chemistry, Applied

Pd/C-Catalyzed Domino Synthesis of Urea Derivatives Using Chloroform as the Carbon Monoxide Source in Water

Liang Wang et al.

ADVANCED SYNTHESIS & CATALYSIS (2018)

添加到收藏夹

Article Chemistry, Medicinal

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain

R. Aldrin Denny et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Iron-catalyzed carbonylation of aryl halides with arylborons using stoichiometric chloroform as the carbon monoxide source

Hongyuan Zhao et al.

GREEN CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source

Guanglong Sun et al.

RSC ADVANCES (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Oxygen-Controlled Catalysis by Vitamin B12-TiO2: Formation of Esters and Amides from Trichlorinated Organic Compounds by Photoirradiation

Hisashi Shimakoshi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Article Chemistry, Organic

Palladium-Catalyzed Heck-type Domino Cyclization and Carboxylation to Synthesize Carboxylic Acids by Utilizing Chloroform as the Carbon Monoxide Source

Xianglei Liu et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

添加到收藏夹

Article Chemistry, Organic

Chloroform as a Carbon Monoxide Precursor: In or Ex Situ Generation of CO for Pd-Catalyzed Aminocarbonylations

Samuel N. Gockel et al.

ORGANIC LETTERS (2015)

添加到收藏夹

Article Chemistry, Organic

Pd-catalyzed Heck cyclization and in situ hydrocarboxylation or hydromethenylation via a hydrogen borrowing strategy

Xianglei Liu et al.

ORGANIC CHEMISTRY FRONTIERS (2015)

添加到收藏夹

Review Chemistry, Multidisciplinary

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001-2011)

Jiang Wang et al.

CHEMICAL REVIEWS (2014)

添加到收藏夹

Article Chemistry, Organic

Iron-Catalyzed Cascade Carbochloromethylation of Activated Alkenes: Highly Efficient Access to Chloro-Containing Oxindoles

Ming-Zhu Lu et al.

ORGANIC LETTERS (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Concise Total Synthesis of Sintokamides A, B, and E by a Unified, Protecting-Group-Free Strategy

Zhenhua Gu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

One-Pot Synthesis of Benzimidazoles by Simultaneous Photocatalytic and Catalytic Reactions on Pt@TiO2 Nanoparticles

Yasuhiro Shiraishi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

添加到收藏夹

Article Chemistry, Medicinal

The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells

Karen Fahey et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

添加到收藏夹

Article Chemistry, Organic

General and practical conversion of aldehydes to homologated carboxylic acids

Lauren R. Cafiero et al.

ORGANIC LETTERS (2008)

添加到收藏夹

Article Chemistry, Organic

Total synthesis of (-)-dysithiazolamide

Ana Arda et al.

ORGANIC LETTERS (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.