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Laura Piccio et al.
ACTA NEUROPATHOLOGICA (2016)
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
Yaming Wang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2016)
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
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Perry G. Ridge et al.
NEUROBIOLOGY OF AGING (2016)
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
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Data publication with the structural biology data grid supports live analysis
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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model
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CELL (2015)
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
Yuka Atagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
Charles C. Bailey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
TREM2 sustains microglial expansion during aging and response to demyelination
Pietro Luigi Poliani et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
Kangyun Wu et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
Taylor R. Jay et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke
Masahito Kawabori et al.
JOURNAL OF NEUROSCIENCE (2015)
3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5
Vongsavanh Phongsisay et al.
MOLECULAR IMMUNOLOGY (2015)
Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus
Ji-Seon Park et al.
TRAFFIC (2015)
Efficient Mammalian Cell Expression and Single-step Purification of Extracellular Glycoproteins for Crystallization
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JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)
Coding variants in TREM2 increase risk for Alzheimer's disease
Sheng Chih Jin et al.
HUMAN MOLECULAR GENETICS (2014)
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
Jason D. Ulrich et al.
MOLECULAR NEURODEGENERATION (2014)
Homozygous TREM2 mutation in a family with atypical frontotemporal dementia
Isabelle Le Ber et al.
NEUROBIOLOGY OF AGING (2014)
Deciphering key features in protein structures with the new ENDscript server
Xavier Robert et al.
NUCLEIC ACIDS RESEARCH (2014)
Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4
Gregory T. Tietjen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases
Daniel L. Kober et al.
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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
Gernot Kleinberger et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
TREM2 Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis
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JAMA NEUROLOGY (2014)
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer's Disease
Bin Zhang et al.
CELL (2013)
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
Sruti Rayaprolu et al.
MOLECULAR NEURODEGENERATION (2013)
A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family
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NEUROBIOLOGY OF AGING (2013)
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Carlos Cruchaga et al.
NEURON (2013)
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
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NEW ENGLAND JOURNAL OF MEDICINE (2013)
TREM2 Variants in Alzheimer's Disease
Rita Guerreiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease
Todd E. Golde et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
Collaboration gets the most out of software
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ELIFE (2013)
Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia-like Syndrome Without Bone Involvement
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JAMA NEUROLOGY (2013)
Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells
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TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells
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EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
Specific lipid recognition is a general feature of CD300 and TREM molecules
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TLT-1s, Alternative Transcripts of Triggering Receptor Expressed on Myeloid Cell-like Transcript-1 (TLT-1), Inhibits the Triggering Receptor Expressed on Myeloid Cell-2 (TREM-2)-mediated Signaling Pathway during Osteoclastogenesis
Soo-Hyun Yoon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Linking Crystallographic Model and Data Quality
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SCIENCE (2012)
Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family
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EUROPEAN JOURNAL OF NEUROLOGY (2011)
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
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MOLECULAR SYSTEMS BIOLOGY (2011)
Features and development of Coot
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ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
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JOURNAL OF NEUROCHEMISTRY (2009)
The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor
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JOURNAL OF NEUROCHEMISTRY (2009)
Salts enhance both protein stability and amyloid formation of an immunoglobulin light chain
Laura A. Sikkink et al.
BIOPHYSICAL CHEMISTRY (2008)
Mutations in TREM2 Lead to Pure Early-Onset Dementia Without Bone Cysts
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HUMAN MUTATION (2008)
TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells
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Structures of T cell immunoglobulin mucin protein 4 show a metal-ion-dependent ligand binding site where phosphatidylserine binds
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TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells
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Identification of Tim4 as a phosphatidylserine receptor
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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
Frank H. Niesen et al.
NATURE PROTOCOLS (2007)
Cutting edge: TREM-2 attenuates macrophage activation
Isaiah R. Turnbull et al.
JOURNAL OF IMMUNOLOGY (2006)
Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
Jessica A. Hamerman et al.
JOURNAL OF IMMUNOLOGY (2006)
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
Noriko Takegahara et al.
NATURE CELL BIOLOGY (2006)
The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
K Takahashi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 Å
MS Kelker et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 Å
MS Kelker et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features
J Paloneva et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Pattern recognition by TREM-2: Binding of anionic ligands
MR Daws et al.
JOURNAL OF IMMUNOLOGY (2003)
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
J Paloneva et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2002)
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