期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 127, 期 -, 页码 206-212出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2015.01.039
关键词
Gemini surfactants; Drug delivery systems; Micelles; Disulfide-thiol exchange; Biodegradable; Stimulus-sensitive polymers
资金
- DGIST R&D Program of the MSIP of Korea [14-NB-2]
Thiol-responsive gemini micelles consisting of hydrophilic poly(ethylene glycol) (PEG) blocks and hydrophobic polylactide (PLA) blocks with a cystine disulfide spacer were reported as effective intracellular nanocarriers of drugs. In the presence of cellular glutathione (GSH) as a reducing agent, gemini micelles gradually destabilize into monomeric micelles through cleavage of the cystine linkage. This destabilization of the gemini micelles changed their size distribution, with the appearance of small aggregates, and led to the enhanced release of encapsulated doxorubicin (DOX). The results obtained from cell culture via confocal laser scanning microscopy (CLSM) for cellular uptake, as well as cell viability measurements for anticancer efficacy suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers. (C) 2015 Elsevier B.V. All rights reserved.
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