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Mark S. Hipp et al.
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Bibek Gooptu et al.
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Romain Volmer et al.
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Jeffrey L. Brodsky et al.
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Ira Tabas et al.
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Peter Walter et al.
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Bryan Chen et al.
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Jonathan B. Baell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
Evan T. Powers et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds
Yan Feng et al.
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Bonnie K. Arendt et al.
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Alena A. Antipova et al.
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T. Kudo et al.
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Aminopyrrolidineamide inhibitors of site-1 protease
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Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress
Satomi Nadanaka et al.
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Cytoplasmic IRE1α-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress
Sung Hoon Back et al.
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CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Anne E. Carpenter et al.
GENOME BIOLOGY (2006)
Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation
K Stegmaier et al.
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PD Lu et al.
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Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II
K Yamamoto et al.
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T Iwawaki et al.
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Bypassing a kinase activity with an ATP-competitive drug
FR Papa et al.
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ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of golgi localization signals
JS Shen et al.
DEVELOPMENTAL CELL (2002)
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
J Ye et al.
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