期刊
ELIFE
卷 5, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.13024
关键词
-
类别
资金
- National Institutes of Health [T32-GM007198, DK091183, DK063491, CA173903, GM085764]
- American Heart Association [12PRE11610007]
- National Cancer Institute [T32CA009523]
- Suomen Kulttuurirahasto North Savo Regional Fund
- Pohjois-Savon Rahasto
- Suomen Kulttuurirahasto The Finnish Foundation for Cardiovascular Research
Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, in vivo they encounter multiple signals that control their varied functions in homeostasis, immunity, and disease. Here, we identify roles of Rev-erb nuclear receptors in regulating responses of mouse macrophages to complex tissue damage signals and wound repair. Rather than reinforcing a specific program of macrophage polarization, Rev-erbs repress subsets of genes that are activated by TLR ligands, IL4, TGF beta, and damage-associated molecular patterns (DAMPS). Unexpectedly, a complex damage signal promotes co-localization of NF-kappa B, Smad3, and Nrf2 at Rev-erb-sensitive enhancers and drives expression of genes characteristic of multiple polarization states in the same cells. Rev-erb-sensitive enhancers thereby integrate multiple damage-activated signaling pathways to promote a wound repair phenotype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据