4.6 Article

Synthesis of amphiphilic hydantoin-based universal peptidomimetics as antibiotic agents

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 21, 期 38, 页码 7702-7706

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d3ob01247f

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Three model hydantoin-based universal peptidomimetics were designed, synthesized, and investigated for their conformation and antibacterial activity. The results demonstrated that these compounds could be promising antibiotics to combat drug resistance.
Three model hydantoin-based universal peptidomimetics were designed and synthetized. Their preferred amphiphilic beta-turn conformation was assessed using molecular modeling and NMR experiments, and their antibacterial activity was tested against Gram-positive and Gram-negative bacteria strains, which demonstrated that these compounds could be a captivating class of antibiotics to fight emergent drug resistance. Three model hydantoin-based universal peptidomimetics were designed, synthetized, and investigated as Gram positive and Gram negative antimicrobial agents.

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