Practical approaches to improving translatability and reproducibility in preclinical pain research

Article Multidisciplinary Sciences

Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function

Min Jung et al.

Summary: The authors generated a cross-species atlas of the dorsal root ganglia, uncovering conserved programs for sensory function that could be used for therapeutic development.

NATURE COMMUNICATIONS (2023)

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Article Biochemistry & Molecular Biology

Mouse spontaneous behavior reflects individual variation rather than estrous state

Dana Rubi Levy et al.

Summary: Animal behavior is influenced by both internal state and individual biases. The hormonal variation during the estrous cycle regulates sociosexual behavior in female mice. However, it is uncertain whether estrous state affects spontaneous behavior and the relationship between these effects and individual behavioral variation.

CURRENT BIOLOGY (2023)

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Article Psychology, Biological

The generalizability crisis

Tal Yarkoni

Summary: Most theories and hypotheses in psychology are verbal in nature, yet their evaluation overwhelmingly relies on inferential statistical procedures. However, many applications of statistical inference in psychology fail to meet the basic condition of closely aligning verbal and statistical expressions, which results in limited generalizability of results, increased false-positive rates, and researchers drawing sweeping verbal generalizations without meaningful connection to statistical quantities.

BEHAVIORAL AND BRAIN SCIENCES (2022)

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Review Neurosciences

Innovations and advances in modelling and measuring pain in animals

Katelyn E. Sadler et al.

Summary: This review discusses recent trends in preclinical pain modelling and provides recommendations for experimental designs that may increase translational success. Best practices in pain behaviour testing have shifted over the past decade due to technological advancements and the emphasis on rigor and reproducibility. The discussion focuses on four fundamental decisions in pain behavior experiments: choice of subject, choice of assay, laboratory environment, and choice of outcome measures.

NATURE REVIEWS NEUROSCIENCE (2022)

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Review Anesthesiology

Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain

Xue Ying Zhang et al.

Summary: Burrowing behaviour is used to assess pain-associated behaviour in laboratory rodents. A systematic review and meta-analysis were conducted to investigate the effects of disease-associated persistent pain models and analgesics on burrowing behaviour. The findings suggest that burrowing could be used as an indicator of pain-associated behaviour and that analgesics can attenuate burrowing deficits.

PAIN (2022)

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Article

Headache: Treatment update

Oyindamola I. Ogunlaja et al.

eNeurologicalSci (2022)

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Article Anesthesiology

Improving Preclinical Development of Novel Interventions to Treat Pain: Insanity Is Doing the Same Thing Over and Over and Expecting Different Results

James C. Eisenach et al.

Summary: Preclinical pain research has made progress over the past 40 years, but the range of drugs available for chronic pain treatment is still limited. To enhance pain treatment, it is important to use clinically relevant animal models and outcome measures that reflect the clinical characteristics of chronic pain syndromes, and to ensure high levels of internal validity, rigor, and reproducibility in experiments. Changing the research culture to prioritize scientific rigor and replication is crucial.

ANESTHESIA AND ANALGESIA (2022)

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Editorial Material Neurosciences

Human cells and networks of pain Transforming pain target identification and therapeutic development

William Renthal et al.

Summary: Chronic pain is a debilitating disease with limited treatment options. Understanding pain cells and networks in humans is crucial for translating knowledge from animal models to therapeutic applications. A multi-institutional collaboration is proposed to address this challenge rigorously and ethically.

NEURON (2021)

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Review Anesthesiology

Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain

Nadia Soliman et al.

Summary: The systematic review and meta-analysis of studies assessing the antinociceptive efficacy of cannabinoids in animal models of pathological or injury-related persistent pain found that cannabinoids significantly attenuated pain-associated behaviors in a broad range of inflammatory and neuropathic pain models. However, reporting of criteria to reduce bias was low and there is potential to enhance the value of future studies by improving methodological reporting and behavioral assessments. Despite this, the evidence supports the hypothesis of cannabinoid-induced analgesia.

PAIN (2021)

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Article Psychology, Biological

Initial evidence of research quality of registered reports compared with the standard publishing model

Courtney K. Soderberg et al.

Summary: Registered reports outperformed standard articles in quality and rigour, with no significant differences in novelty and creativity, while showing substantial improvements in the rigour of methodology, analysis, and overall paper quality. This suggests that RRs could enhance research quality, combat publication bias, and ultimately increase the credibility of published literature.

NATURE HUMAN BEHAVIOUR (2021)

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Review Anesthesiology

A systematic review and meta-analysis of pregabalin preclinical studies

Carole A. Federico et al.

PAIN (2020)

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Review Neurosciences

Reproducibility of animal research in light of biological variation

Bernhard Voelkl et al.

NATURE REVIEWS NEUROSCIENCE (2020)

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Article Medicine, General & Internal

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Theo Vos et al.

LANCET (2020)

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Article Multidisciplinary Sciences

Improving reproducibility in animal research by splitting the study population into several 'mini-experiments'

Vanessa Tabea von Kortzfleisch et al.

SCIENTIFIC REPORTS (2020)

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Article Immunology

Neuroimmune interactions in chronic pain - An interdisciplinary perspective

Zoe Hore et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Article Chemistry, Medicinal

Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7

John V. Mulcahy et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis

Gillian L. Currie et al.

PLOS BIOLOGY (2019)

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Review Neurosciences

The Genetics of Neuropathic Pain from Model Organisms to Clinical Application

Margarita Calvo et al.

NEURON (2019)

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Article Psychiatry

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples

Richard Border et al.

AMERICAN JOURNAL OF PSYCHIATRY (2019)

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Article Ethics

A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

Kaitlyn Hair et al.

RESEARCH INTEGRITY AND PEER REVIEW (2019)

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Article Veterinary Sciences

PREPARE: guidelines for planning animal research and testing

Adrian J. Smith et al.

LABORATORY ANIMALS (2018)

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Review Anesthesiology

Sensory profiling in animal models of neuropathic pain: a call for back-translation

Andrew S. C. Rice et al.

PAIN (2018)

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Article Anesthesiology

Efficacy of the Na(v)1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy

Aoibhinn McDonnell et al.

PAIN (2018)

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Article Biochemistry & Molecular Biology

Reproducibility of preclinical animal research improves with heterogeneity of study samples

Bernhard Voelkl et al.

PLOS BIOLOGY (2018)

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Article Psychology, Social

When power analyses based on pilot data are biased: Inaccurate effect size estimators and follow-up bias

Casper Albers et al.

JOURNAL OF EXPERIMENTAL SOCIAL PSYCHOLOGY (2018)

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Review Anesthesiology

Translational pain assessment: could natural animal models be the missing link?

Mary P. Klinck et al.

PAIN (2017)

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Review Physiology

PATHOPHYSIOLOGY OF MIGRAINE: A DISORDER OF SENSORY PROCESSING

Peter J. Goadsby et al.

PHYSIOLOGICAL REVIEWS (2017)

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Article Biology

Standardized mean differences cause funnel plot distortion in publication bias assessments

Peter-Paul Zwetsloot et al.

ELIFE (2017)

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Article Anesthesiology

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

Nick A. Andrews et al.

PAIN (2016)

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Article Anesthesiology

Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study

Rachel Wodarski et al.

PAIN (2016)

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Article Biology

Publication bias and the canonization of false facts

Silas Boye Nissen et al.

ELIFE (2016)

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Article Multidisciplinary Sciences

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

Jack W. Scannell et al.

PLOS ONE (2016)

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Review Immunology

Sex differences in immune responses

Sabra L. Klein et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Article Neurosciences

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics

Tuan Trang et al.

JOURNAL OF NEUROSCIENCE (2015)

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Article Multidisciplinary Sciences

Estimating the reproducibility of psychological science

Alexander A. Aarts et al.

SCIENCE (2015)

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Article Multidisciplinary Sciences

Likelihood of Null Effects of Large NHLBI Clinical Trials Has Increased over Time

Robert M. Kaplan et al.

PLOS ONE (2015)

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Article Veterinary Sciences

Randomized Block Experimental Designs Can Increase the Power and Reproducibility of Laboratory Animal Experiments

Michael F. W. Festing

ILAR JOURNAL (2014)

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Article Anesthesiology

The effect of oxcarbazepine in peripheral neuropathic pain depends on pain phenotype: A randomised, double-blind, placebo-controlled phenotype-stratified study

Dyveke T. Demant et al.

PAIN (2014)

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Review Neurosciences

Power failure: why small sample size undermines the reliability of neuroscience

Katherine S. Button et al.

NATURE REVIEWS NEUROSCIENCE (2013)

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Article Biotechnology & Applied Microbiology

How were new medicines discovered?

David C. Swinney et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

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Article Biochemistry & Molecular Biology

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Emily S. Sena et al.

PLOS BIOLOGY (2010)

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Article Medicine, General & Internal

Can Animal Models of Disease Reliably Inform Human Studies?

H. Bart van der Worp et al.

PLOS MEDICINE (2010)

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Review Neurosciences

Animal models of pain: progress and challenges

Jeffrey S. Mogil

NATURE REVIEWS NEUROSCIENCE (2009)

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Review Rheumatology

The discovery and development of antiinflammatory drugs

K Brune et al.

ARTHRITIS AND RHEUMATISM (2004)

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Review Medicine, General & Internal

Problems of reporting genetic associations with complex outcomes

HM Colhoun et al.

LANCET (2003)

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Article Clinical Neurology

CGRP may play a causative role in migraine

LH Lassen et al.

CEPHALALGIA (2002)

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Practical approaches to improving translatability and reproducibility in preclinical pain research

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