期刊
CUREUS JOURNAL OF MEDICAL SCIENCE
卷 15, 期 9, 页码 -出版社
SPRINGERNATURE
DOI: 10.7759/cureus.45815
关键词
jc virus; malignancy; cns lymphoma; immunocompetent; pml; progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a viral infection caused by the John Cunningham virus (JCV). We reported a case of a 74-year-old male who presented with progressive memory loss, episodic confusion, and aphasia. Initially suspected as CNS lymphoma, the diagnosis was confirmed as PML through microscopic examination and molecular testing.
Progressive multifocal leukoencephalopathy (PML) is an infection caused by the John Cunningham virus (JCV), usually in an immunocompromised host. We present the case of a 74-year-old male who presented with a six-week history of progressive memory loss, episodic confusion, and aphasia. Cranial nerve, motor, sensory, and coordination testing were unremarkable. Magnetic resonance imaging (MRI) of the brain and spectroscopy were concerning for primary CNS lymphoma vs. diffuse glioma. Microscopic examination after the patient underwent left frontal stereotactic brain biopsy was suggestive of a viral infection, and further testing with JCV DNA in-situ hybridization (ISH) confirmed the diagnosis of PML. The patient's condition started resolving without treatment. This case demonstrates, to our knowledge, the first known case of primary PML masquerading as CNS lymphoma in modern literature.
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