Stem cells as a regenerative medicine approach in treatment of microvascular diabetic complications

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood glucose and is associated with high morbidity and mortality among the diabetic population. Uncontrolled chronic hyperglycaemia causes increased formation and accumulation of different oxidative and nitrosative stress markers, resulting in micro vascular and macrovascular complications, which might seriously affect the quality of a patient's life. Conventional treatment strategies are confined to controlling blood glucose by regulating the insulin level and are not involved in attenuating the life-threatening complications of diabetes mellitus. Thus, there is an unmet need to develop a viable treatment strategy that could target the multi-etiological factors involved in the pathogenesis of diabetic complications. Stem cell therapy, a regenerative medicine approach, has been investigated in diabetic

Automated summary

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose, resulting in oxidative and nitrosative stress markers and complications. Conventional treatment only focuses on controlling blood glucose, without addressing the complications. Therefore, it is necessary to develop a treatment strategy targeting multiple factors involved in diabetic complications.