期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 135, 期 -, 页码 201-208出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2015.07.068
关键词
Nanocrystalline zeolite; Hydroxyapatite; Bio nanocomposite; Simulated body fluid; Bioactivity
资金
- Department of Science and Technology, New Delhi (DST) [SB/S1/PC-91/2012]
- CSIR, New Delhi for SRF fellowship
Silver ion-exchanged nanocrystalline zeolite (Ag-Nano-ZSM-5) and silver ion-exchanged conventional zeolite (Ag-ZSM-5) were synthesized. Zeolites were incubated in simulated body fluid at 310 K for different time periods to grow hydroxyapatite in their matrixes. Significant large amount of hydroxyapatite was grown in Ag-Nano-ZSM-5 matrix after incubation in simulated body fluid when compared to Ag-ZSM-5. The resultant material was characterized using X-ray diffraction, N-2-adsorption, scanning/transmission electron microscopy, energy dispersive X-ray, and inductively coupled plasma analysis. Mechanical properties such as compressive modulus, compressive strength, and strain at failure of the parent materials were evaluated. Biocompatibility assays suggested that Ag-Nano-ZSM-5 and hydroxyapatite grown in Ag-Nano-ZSM-5 were compatible and did not impose any toxicity to RAW 264.7 cells macrophase and Caco2 cells suggesting considerable potential for biomedical applications such as bone implants. (C) 2015 Elsevier B.V. All rights reserved.
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