期刊
INTERNATIONAL JOURNAL OF SURGERY
卷 109, 期 9, 页码 2689-2695出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JS9.0000000000000429
关键词
overall survival; retroperitoneal tumor; surgery; venous thromboembolism
类别
The study found that age, recurrence, and vascular resection are independent risk factors associated with VTE in patients undergoing retroperitoneal tumor surgery. VTE was also linked to inferior overall survival in these patients.
Background: Venous thromboembolism (VTE) is a common postoperative complication; however, the incidence and risk stratification of postoperative VTE in patients with retroperitoneal tumor remains unclear. The authors aim to quantify the incidence, identify risk factors, and determine the outcomes of VTE in patients undergoing retroperitoneal tumor surgery. Methods: The authors retrospectively reviewed the characteristics, perioperative outcomes, and overall survival (OS) of patients (VTE and non-VTE) who underwent retroperitoneal tumor surgery between 2015 and 2020. Perioperative and oncologic outcomes were compared using propensity-matching and Cox analyses. Results: Of 1223 patients with retroperitoneal tumor surgery, 2.1% had VTE. Age [odds ratio (OR) 1.140, 95% CI: 1.053-1.239, P=0.004], recurrence (OR 1.851, 95% CI: 1.241-2.761, P=0.003), and vascular resection (OR 2.036, 95% CI: 1.054-3.934, P=0.034) were independent risk factors, with significant between-group differences regarding age, recurrence, sarcoma, organ resection, vascular resection, and operation time. No between-group differences in 30-day all-cause mortality (8 vs. 4%, OR 0.657, 95% CI: 0.375-1.151, P=0.427) and major complications (12 vs. 8%, OR 0.775, 95% CI: 0.483-1.244, P=0.572) were observed. Mean hospitalization duration (20.1 vs. 22.9 days, OR 1.153, 95% CI: 1.022-1.386, P=0.033) and ICU stay (3.2 vs. 5.5 days, OR 1.193, 95% CI: 1.034-1.347, P=0.012) were shorter in non-VTE versus VTE, respectively, with inferior OS (hazard ratio 2.090, 95% CI: 1.014-4.308, P=0.046) in VTE. Conclusions: Age, recurrence, and vascular resection are positively associated with VTE, which is associated with inferior OS.
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