4.5 Article

Proteomic profile of the venom of three dark-colored Tityus (Scorpiones: Buthidae) from the tropical rainforests of Costa Rica

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

A proteomic overview of the major venom components from Tityus championi from Panama

Marcos H. Salazar et al.

Summary: In recent years, there has been an increase in morbidity caused by Tityus championi scorpion sting in Panama. The LD50 of the venom was determined to be 2.9 mg/kg through intravenous injection. Toxic fractions of the venom were identified and tested in mice to find the most toxic fractions to mammals. Additionally, the venom fractions were tested against invertebrates to search for insect-specific toxin peptides. The primary structures of the most relevant venom peptides were obtained, with one of the neurotoxic peptides being found in at least four other Tityus species in Panama. This neurotoxin could be an important protein target for developing antivenoms against the sting of this Panamanian scorpion or other relevant Tityus species.

TOXICON (2023)

Article Pharmacology & Pharmacy

On the noxious black Amazonian scorpion, Tityus obscurus (Scorpiones, Buthidae): Taxonomic notes, biology, medical importance and envenoming treatment

Jonas Gama Martins et al.

Summary: Tityus obscurus has caused medical accidents in the Brazilian Amazon and French Guiana. It has sexual dimorphism but uniform black coloration in males and females. Most stings occur in non-flooded forest areas where rural communities are located. People in remote areas use native plants to alleviate pain and vomiting caused by scorpion stings. The lack of knowledge about the natural distribution of these scorpions poses challenges in treating envenomation. The study provides information on the natural history of T. obscurus and proposes experimental approaches for producing efficient antivenom.

TOXICON (2023)

Article Tropical Medicine

Scorpion envenomation in Brazil: Current scenario and perspectives for containing an increasing health problem

Clara Guerra-Duarte et al.

PLoS Neglected Tropical Diseases (2023)

Article Biochemistry & Molecular Biology

An overview of Tityus cisandinus scorpion venom: Transcriptome and mass fingerprinting reveal conserved toxin homologs across the Amazon region and novel lipolytic components

Yan Kalapothakis et al.

Summary: In this study, the first venom gland transcriptomic analysis of the Amazonian scorpion T. cisandinus outside Brazil was conducted. The total venom was also analyzed using MALDI-TOF MS, which supported the transcriptomic findings. The study revealed a high similarity between the venoms of T. cisandinus and T. obscurus, indicating the existence of a neglected complex of genetically and toxinologically related Amazonian scorpions of medical importance. Furthermore, it was found that currently available therapeutic sera have low recognition against the venoms of T. cisandinus and T. obscurus, highlighting the need for improvement to protect against envenomation by Amazonian Tityus spp.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Biochemistry & Molecular Biology

Venomics of the Scorpion Tityus ocelote (Scorpiones, Buthidae): Understanding Venom Evolution in the Subgenus Archaeotityus

Cecilia Diaz et al.

Summary: This study characterized the venom of Tityus ocelote from Costa Rica, identified some novel venom components, and revealed the complexity of this venom through phylogenetic analysis, showing its relationship with different lineages within the genus Tityus.

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2022)

Article Pharmacology & Pharmacy

Novel components of Tityus serrulatus venom: A transcriptomic approach

Yan Kalapothakis et al.

Summary: Several research groups have investigated the components produced by the venom gland of the scorpion Tityus serrulatus, focusing on neurotoxins, enzymes, and new transcripts. Transcriptomes and proteomes have provided crucial information for pharmacological, biochemical, and immunological research, with next-generation sequencing allowing the identification of new components.

TOXICON (2021)

Review Pharmacology & Pharmacy

Scorpions and scorpion sting envenoming (scorpionism) in the Arab Countries of the Middle East

Zuhair S. Amr et al.

Summary: The Middle East is home to 117 species of scorpions, with 22 species considered dangerously venomous. Countries like Saudi Arabia, Iraq, and Jordan report the highest numbers of scorpion stings. The main toxins in Old World scorpion venom target sodium channels and can lead to serious consequences like myocardial damage.

TOXICON (2021)

Review Toxicology

Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world's most diverse rainforest

Adolfo Borges et al.

Summary: The venom from Amazonian scorpions of the genus Tityus can cause distinct clinical, mainly neurological, symptoms, in contrast to autonomic manifestations from congeneric southern and northern South American species. This study synthesized toxinological, clinical, and molecular data from affected areas in the Amazon, highlighting potential diversity gradients in venom components despite strong phylogenetic associations among species. Efforts are needed across affected nations to develop treatments and understanding for this neglected disease.

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES (2021)

Review Critical Care Medicine

Scorpion envenomation: state of the art

Fekri Abroug et al.

INTENSIVE CARE MEDICINE (2020)

Article Chemistry, Medicinal

Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides

Caroline B. F. Mourao et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Electrophysiological characterization of Tityus obscurus beta toxin 1 (To1) on Na+-channel isoforms

Diogo Vieira Tibery et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)

Article Infectious Diseases

Inhibition of Tityus serrulatus venom hyaluronidase affects venom biodistribution

Barbara Bruna Ribeiro de Oliveira-Mendes et al.

PLOS NEGLECTED TROPICAL DISEASES (2019)

Article Infectious Diseases

Estimating snakebite incidence from mathematical models: A test in Costa Rica

Carlos A. Bravo-Vega et al.

PLOS NEGLECTED TROPICAL DISEASES (2019)

Article Biochemistry & Molecular Biology

Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona

Edson Norberto Carcamo-Noriega et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2018)

Article Pharmacology & Pharmacy

Venoms of Centruroides and Tityus species from Panama and their main toxic fractions

Marcos H. Salazar et al.

TOXICON (2018)

Article Multidisciplinary Sciences

Differential toxicity and venom gland gene expression in Centruroides vittatus

Thomas McElroy et al.

PLOS ONE (2017)

Review Pharmacology & Pharmacy

Tityus serrulatus venom - A lethal cocktail

Manuela Berto Pucca et al.

TOXICON (2015)

Article Biochemistry & Molecular Biology

Fibrin(ogen)olytic enzymes in scorpion (Tityus discrepans) venom

Josmary Brazon et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2014)

Review Toxicology

Scorpionism in Central America, with special reference to the case of Panama

A. Borges et al.

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES (2012)

Article Biochemistry & Molecular Biology

Positions under Positive Selection-Key for Selectivity and Potency of Scorpion α-Toxins

Hagar Weinberger et al.

MOLECULAR BIOLOGY AND EVOLUTION (2010)

Article Biochemistry & Molecular Biology

Proteomic analysis of the venom and characterization of toxins specific for Na+- and K+-channels from the Colombian scorpion Tityus pachyurus

J Barona et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2006)

Article Public, Environmental & Occupational Health

Scorpion envenoming in two regions of Colombia:: clinical, epidemiological and therapeutic aspects

R Otero et al.

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2004)

Article Pharmacology & Pharmacy

Scorpion toxins from Tityus cambridgei that affect Na+-channels

CVF Batista et al.

TOXICON (2002)