期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 133, 期 -, 页码 179-188出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2015.05.048
关键词
Electrospinning; Multi-layered vascular scaffolds; P(LLA-CL); Collagen; Chitosan; Tissue engineering
资金
- National Nature Science Foundation of China [31470941, 31271035, 51403033]
- Science and Technology Commission of Shanghai Municipality [11nm0506200]
- Ph.D. Programs Foundation of Ministry of Education of China [20130075110005]
- light of textile project [J201404]
- Fundamental Research Funds for the Central Universities
- Deanship of Scientific Research at King Saud University [RGP-201]
Multi-layered scaffolds are advantageous in vascular tissue engineering, in consideration of better combination of biomechanics, biocompatibility and biodegradability than the scaffolds with single structure. In this study, a bi-directional gradient electrospinning method was developed to fabricate poly(L-lactide-co-caprolactone) (P(LLA-CL)), collagen and chitosan based tubular scaffold with multi-layered symmetrical structure. The multi-layered composite scaffold showed improved mechanical property and biocompatibility, in comparison to the blended scaffold using the same proportion of raw materials. Endothelialization on the multi-layered scaffold was accelerated owing to the bioactive surface made of pure natural materials. hSMCs growth showed the similar results because of its better biocompatibility. Additionally, fibers morphology change, pH value balance and long term mechanical support results showed that the gradient structure effectively improved biodegradability. (C) 2015 Elsevier B.V. All rights reserved.
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