期刊
CURRENT RHEUMATOLOGY REPORTS
卷 18, 期 3, 页码 -出版社
SPRINGER
DOI: 10.1007/s11926-016-0563-2
关键词
Rheumatoid arthritis (RA); Lung; Pulmonary; Smoking; Anti-citrullinated protein antibodies (ACPA); Pre-RA
类别
资金
- Rheumatology Research Foundation
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [K23 AR069688, L30 AR066953, R01 AR049880, K24 AR052403, P60 AR047782]
While the etiology of rheumatoid arthritis (RA) remains to be fully elucidated, recent research has advanced the understanding of RA pathogenesis to the point where clinical trials for RA prevention are underway. The current paradigm for RA pathogenesis is that individuals progress through distinct preclinical phases prior to the onset of clinically apparent RA. These preclinical RA phases consist of genetic risk, local inflammation, presence of RA-related autoantibodies, asymptomatic systemic inflammation, and early non-specific symptoms prior to clinical seropositive RA. Epidemiologic studies have been important in forming hypotheses related to the biology occurring in preclinical RA. Specifically, studies associating cigarette smoking with overall RA risk as well as transitions between phases of preclinical RA were vital in helping to establish the lung as a potential important initiating site in the pathogenesis of seropositive RA. Herein, we review the epidemiology associating smoking with transitions in preclinical phases of RA as well as the recent literature supporting the lung as a critical site in RA pathogenesis.
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