α-Difluoroalkylation of Benzyl Amines with Trifluoromethylarenes

An alpha-difluoroalkylation of benzyl amines with trifluoromethylarenes is disclosed herein. This protocol is characterized by its operational simplicity, excellent chemoselectivity and broad scope-even with advanced synthetic intermediates-, thus offering a new entry point to medicinally-relevant alpha-difluoroalkylated amines from simple, yet readily accessible, precursors.

Automated summary

An alpha-difluoroalkylation reaction of benzyl amines with trifluoromethylarenes is described. The protocol offers simplicity, excellent chemoselectivity, and broad applicability, even with advanced synthetic intermediates, to access medicinally-relevant alpha-difluoroalkylated amines from easily accessible precursors.