Implantable, Biodegradable, and Wireless Triboelectric Devices for Cancer Therapy through Disrupting Microtubule and Actins Dynamics

Article Chemistry, Multidisciplinary

Ultrasound-Driven On-Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

Iman M. Imani et al.

Summary: This study proposes a new strategy of using an ultrasound-driven implantable vibrational nanogenerator to eliminate microorganisms in deep tissue.

ADVANCED SCIENCE (2023)

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Article Chemistry, Multidisciplinary

Bioinspired Electron Polarization of Nanozymes with a Human Self-Generated Electric Field for Cancer Catalytic Therapy

Shuncheng Yao et al.

Summary: This study develops a human self-driven catalysis-promoting system to improve the reactive oxygen species (ROS) generation efficiency of nanocatalysts for cancer therapy. The system demonstrates high catalytic ROS generation efficiency and offers a new therapeutic mode for self-driven at-home therapy.

ADVANCED MATERIALS (2022)

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Article Multidisciplinary Sciences

Ultrasound-mediated triboelectric nanogenerator for powering on-demand transient electronics

Dong-Min Lee et al.

Summary: On-demand transient electronics offer exceptional clinical experiences in diagnosis, treatment, and rehabilitation, but their use is limited by conventional power supplies. In this study, we report an ultrasound-mediated transient triboelectric nanogenerator that can generate and degrade energy based on well-defined triggering events. This research provides insight into the practical use of implantable TENGs based on ultrasound-triggered transient material design.

SCIENCE ADVANCES (2022)

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Article Multidisciplinary Sciences

An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields

Yilin Yang et al.

Summary: A promising alternative for treating brain tumors has been developed by creating an implantable ultrasound-powered tumor treating device (UP-TTD) that disrupts cancer cell division without harming normal neurons. In vitro and in vivo experiments demonstrate significant therapeutic effects, with inhibition of tumor cell growth rate and reduction of cancer area. The UP-TTD is wireless, compact, lightweight, and can be adjusted without increasing its size or adding circuits.

SCIENCE ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Self-driven Electrical Stimulation Promotes Cancer Catalytic Therapy Based on Fully Conjugated Covalent Organic Framework Nanocages

Shuncheng Yao et al.

Summary: In this work, a human self-driven electrical stimulation enhanced catalytic system based on wearable triboelectric nanogenerator (TENG) and fully pi-conjugated covalent organic framework nanocages (hCOF) for improving cancer therapy is created.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Self-Powered, Implantable, and Wirelessly Controlled NO Generation System for Intracranial Neuroglioma Therapy

Shuncheng Yao et al.

Summary: This article reports on a self-powered, wirelessly controlled gas therapy system for intracranial neuroglioma treatment. The system utilizes a self-powered triboelectric nanogenerator and an implantable nitric oxide releasing device. The efficacy of the system is validated in mouse breast cancer models and rat glioblastoma multiforme.

ADVANCED MATERIALS (2022)

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Article Chemistry, Physical

Triboelectric current stimulation alleviates in vitro cell migration and in vivo tumor metastasis

Binbin Chu et al.

Summary: This study presents a novel electrotherapeutic strategy using triboelectric nanogenerators (TENG) to suppress cancer cell migration in vitro and alleviate early tumor metastasis in vivo. The TENG stimulation with an output current of 150 μA can effectively destroy the cellular cytoskeleton and inhibit cancer cell migration. In mouse models, TENG-based treatments with the current of 150 μA prevent cancer cell spreading to other body sites without apparent toxicity to normal organs and tissues.

NANO ENERGY (2022)

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Article Chemistry, Multidisciplinary

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death

Marcos Rios Garcia et al.

Summary: AAA+-ATPase thyroid hormone receptor interacting protein 13 (Trip13) depletion in hepatocellular carcinoma cells leads to accumulation of lipid droplets, disrupting mitotic spindle polarity and resulting in mitotic cell death. Perilipin 2 (Plin2), a lipid-droplet-coating protein, is crucial for multipolar spindle formation, induction of DNA damage, and mitotic cell death. Assessment of Plin2 levels enables the stratification of tumor responsiveness to mitosis-targeting drugs.

ADVANCED SCIENCE (2022)

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Article Multidisciplinary Sciences

The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER+ breast cancer with mitotic aberrations

Isabel Soria-Bretones et al.

Summary: In this study, a panel of CDK4/6i-resistant breast cancer cell lines and patient-derived organoids were developed. It was found that RB1 loss caused mitotic defects and enhanced sensitivity to TTK inhibition, suggesting TTK inhibitor CFI-402257 as a potential therapeutic strategy for CDK4/6i-resistant breast cancer patients.

SCIENCE ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Stretchable, Washable, and Ultrathin Triboelectric Nanogenerators as Skin-Like Highly Sensitive Self-Powered Haptic Sensors

Yang Jiang et al.

Summary: This study presents a stretchable, washable, and ultrathin skin-inspired triboelectric nanogenerator (SI-TENG) for harvesting human motion energy and acting as a highly sensitive self-powered haptic sensor. With optimized design, the generator achieves efficient energy harvesting and self-powered sensing, making it applicable for human-machine interfaces and security systems.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Breathable Nanogenerators for an On-Plant Self-Powered Sustainable Agriculture System

Lingyi Lan et al.

Summary: The article introduces a waterproof and breathable triboelectric nanogenerator that can self-attach to plant leaves and harvest environmental energy from wind and raindrops. This generator can serve as a sustainable power supply for plant sensors, enabling real-time monitoring of plant health status.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Mechanochemical bond scission for the activation of drugs

Shuaidong Huo et al.

Summary: This study demonstrated the potential of ultrasound to activate mechanoresponsive prodrug systems by controlled scission of covalent and non-covalent bonds, releasing various drugs and showing a promising new strategy for drug activation.

NATURE CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Chromosomally unstable tumor cells specifically require KIF18A for proliferation

Carolyn Marquis et al.

Summary: Chromosomal instability (CIN) is a hallmark of tumor cells, caused by changes in microtubule dynamics and control compromising the mitotic spindle. Inhibition of KIF18A results in mitotic delays, multipolar spindles, and increased cell death in CIN tumor cells. Sensitivity to KIF18A knockdown is strongly correlated with centrosome fragmentation, providing a potential target to reduce proliferative capacity of CIN cells.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation

Mengjie Sun et al.

Summary: In this study, it was shown that NuMA undergoes liquid-liquid phase separation during mitotic entry, condensing on spindle poles and enriching critical components to promote spindle assembly.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Epigenetic Remodeling Hydrogel Patches for Multidrug-Resistant Triple-Negative Breast Cancer

Xiaoyuan Ji et al.

Summary: The hydrogel patch designed to modulate the plasticity of T-ICs in TNBC shows promising results in improving chemosensitivity, enhancing tumor immunogenicity, and increasing T-cell infiltration. Additionally, the patch efficiently suppresses tumor growth, postsurgical relapse, and metastasis with a single dose, demonstrating superior efficacy against multidrug resistance.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary