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Review
Urology & Nephrology
Oskar Bergengren et al.
Summary: This article systematically reviews and summarizes the descriptive epidemiology, large screening studies, diagnostic techniques, and risk factors of prostate cancer (PCa). PCa is the second most common cancer worldwide, with the highest incidence in North and South America, Europe, Australia, and the Caribbean. Risk factors include age, family history, genetic predisposition, smoking, diet, physical activity, specific medications, and occupational factors.
Review
Chemistry, Medicinal
Mohammad Mahboob Alam
Summary: Recent advancements in 1,2,3-triazole hybrids have shown promising potential in the development of anticancer agents. These compounds exhibit remarkable biological potential and offer significant opportunities in combating cancer.
ARCHIV DER PHARMAZIE
(2022)
Review
Oncology
Chunyan Zong et al.
Summary: PARP enzymes, especially PARP1, play important roles in DNA damage response and genome stability maintenance. PARPis can be used as a therapeutic approach for BRCA-deficient tumors, not only through catalytic inhibition and DNA trapping, but also by affecting tumor's immune modulation.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Fenghai Zhao et al.
Summary: A series of compounds containing trifluoroacetyl groups were synthesized and evaluated for their insecticidal activity against Nilaparvata lugens and Aphis craccivora. The study found that compound 4-1, 4-2, and 4-19 showed the best activity against Nilaparvata lugens at 100 mg/L concentration. Structure-activity relationship of different substituents of R-1 or R-2 was investigated, and molecular docking of compounds 4-1 and 4-2 was discussed.
MOLECULAR DIVERSITY
(2022)
Review
Chemistry, Medicinal
Xinyi Wu et al.
Summary: This review provides a comprehensive analysis of the potential of 1,2,3-triazole derivatives in anti-breast cancer research, summarizing the latest progress in this field. By understanding their mechanisms of action and structure-activity relationships, it can provide theoretical guidance for the design of more effective drug candidates.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Mehlika Dilek Altintop et al.
Summary: New arylidene indanones were synthesized and evaluated for their anticancer activity against lung carcinoma and prostate cancer cells. Several compounds showed higher cytotoxicity than the commonly used drug cisplatin. In vitro assays revealed that compounds 2 and 4 had potential as targeted therapeutic agents for non-small cell lung carcinoma.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fernando Lopez-Campos et al.
Summary: The use of immunotherapy has had a significant impact on cancer treatment, but it has not been as effective for metastatic castration-resistant prostate cancer (mCRPC) due to the complex and immune-suppressive microenvironment of prostate cancer. Identifying molecular biomarkers for predicting treatment response is a key challenge. However, there are promising developments in immunotherapy treatments, such as immune checkpoint inhibitors combinations, BiTE® immune therapies, and chimeric antigen receptors (CAR) that may address this issue.
Review
Biochemistry & Molecular Biology
Mamello Sekhoacha et al.
Summary: Prostate cancer is a malignancy that affects men globally and presents either as localized or advanced disease. This article aims to provide a comprehensive overview of prostate cancer, including disease diagnosis, pathogenic gene mutations, and treatment options. Ongoing research is focusing on alternative treatment approaches such as traditional medicine, nanotechnologies, and gene therapy to combat prostate cancer, drug resistance, and reduce adverse effects.
Review
Urology & Nephrology
Fabio Turco et al.
Summary: Metastatic castration resistant prostate cancer is a fatal disease, but several treatments have shown effectiveness in improving patient outcomes. For non-metastatic patients, adding enzalutamide, apalutamide, and darolutamide to androgen deprivation therapy improves survival rates. For metastatic patients, there are various treatment options available. Despite the availability of multiple treatment methods, there are still unmet clinical needs.
RESEARCH AND REPORTS IN UROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yundong He et al.
Summary: This review summarizes the targeted agents and their mechanisms for treating prostate cancer (PCa), as well as discusses their limitations and future directions.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Infectious Diseases
Naili Moreira da Silva et al.
Summary: This study focused on the design and synthesis of 1,2,3-triazole derivatives of 8-hydroxyquinoline with potential antifungal properties. The results showed promising activities against yeast and dermatophytes, but not significant activity against Fusarium spp. The compounds exhibited low leukocyte toxicity and potential damage to the fungal cell wall. The scaffold appears to be a potential pharmacophore for the development of new antifungal agents.
Review
Oncology
Dhruv Bansal et al.
Summary: Immunotherapy has revolutionized the treatment of various malignancies, but its efficacy in prostate cancer remains limited due to the immunosuppressive tumor microenvironment. Clinical trials are now focusing on combination therapies to enhance anti-tumor immune responses, including immunomodulatory agents and conventional treatments. Promising new approaches, such as vaccine-based therapies and checkpoint inhibitors, are being explored to improve outcomes for patients with metastatic castrate-resistant prostate cancer.
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Oncology
Verane Achard et al.
Summary: Metastatic prostate cancer treatment has shifted with the introduction of novel therapeutic agents, requiring clinicians to choose the most appropriate treatment combination and sequence for each patient based on individual factors to optimize efficacy.
Review
Biochemistry & Molecular Biology
Ivan Henriquez et al.
Summary: mCRPC is a complex disease with a wide range of molecular tumor behavior and high risk of progression, making early detection and treatment crucial. Treatment options have improved significantly in recent years, but clinicians find it challenging to keep up with the rapidly changing therapeutic landscape.
Review
Pharmacology & Pharmacy
Lesley J. Scott
Article
Oncology
Huairui Yuan et al.
Article
Pharmacology & Pharmacy
Wen-Jun Wang et al.
PHARMACOLOGICAL RESEARCH
(2020)
Review
Chemistry, Medicinal
Feng Gao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Khurshed Bozorov et al.
BIOORGANIC & MEDICINAL CHEMISTRY
(2019)
Review
Chemistry, Medicinal
Zhi Xu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Genetics & Heredity
Alan D. D'Andrea
Article
Urology & Nephrology
Niranjan J. Sathianathen et al.
NATURE REVIEWS UROLOGY
(2018)
Article
Pharmacology & Pharmacy
Anita D. Ballantyne et al.
Article
Biochemistry & Molecular Biology
Jungmin Seo et al.
NUCLEIC ACIDS RESEARCH
(2012)
Review
Chemistry, Medicinal
Y. Xia et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2010)
