期刊
CHEMISTRYOPEN
卷 5, 期 3, 页码 227-235出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/open.201500216
关键词
4,4'-dimetoxytrityl; antiviral; dengue; flavivirus; nucleoside analogues; trityl; yellow fever
A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5 '-O-tritylated and the 5 '-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5 ' O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at mu m concentrations, however significantly weaker potency against YFV.
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