☆ 4.7 Review

Cytokine-Induced Memory-Like NK Cells: Emerging strategy for AML immunotherapy

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Immunology

Harnessing the power of memory-like NK cells to fight cancer

Yun Yan Foo et al.

Summary: The success of NK cells in eliminating tumors depends on their strong immunosurveillance capacity, but the tumor microenvironment releases inhibitory factors that dampen NK cell functionality against tumors. Transforming naive NK cells into memory-like NK cells can enhance their ability to target tumors and overcome this challenge.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2023)

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Review Immunology

NK cell therapy in relapsed refractory multiple myeloma

Elham Roshandel et al.

Summary: Recent advances in adoptive cell therapy have transformed cancer immunotherapy, with a focus on treating relapsed/refractory multiple myeloma (RR/MM) using natural killer (NK) cells. NK cells exhibit effective cytotoxic activity against myeloma cells and can be derived from the patient or allogenic donors for therapy. Novel cell-based products, such as NK cell lines and CAR-NK cells, offer promising options for off-the-shelf NK cell therapy in MM.

CLINICAL IMMUNOLOGY (2023)

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Review Immunology

NK cell defects: implication in acute myeloid leukemia

Selma Z. D'Silva et al.

Summary: Acute Myeloid Leukemia (AML) is a complex and rapidly progressing disease with poor outcomes. Natural Killer cells have been shown to have potential against AML, but disease-associated defects can limit their effectiveness. Different NK cell therapies, such as adoptive NK cell transfer and CAR-NK cell therapy, have shown promise, but data is limited and outcomes vary. In this mini-review, the role of NK cell defects in AML progression, available therapies, and trial results are discussed.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Oncology

Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers

Jordi Pfeifer Serrahima et al.

Summary: Chimeric antigen receptor (CAR)-engineered immune effector cells show promise in cancer immunotherapy, but face challenges of toxicity and immune escape. Adaptor CARs triggered by bispecific molecules that crosslink CAR with tumor-associated antigens may overcome these challenges. In this study, NK cells were genetically modified to express a universal CAR (UniCAR) and redirected to tumor cells using target modules (TMs) containing an ErbB2-specific antibody domain and a UniCAR-recognized peptide. Different TM designs and CAR compositions affected cell killing activity, with TMs carrying two or three E5B9 epitopes being more effective with the first-generation UniCAR, while the second-generation UniCAR was more active with TMs carrying one E5B9 sequence. These findings have implications for the development of optimized UniCAR and TM combinations in cancer immunotherapy.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

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Meeting Abstract Oncology

Combination of cytokines and PM21-particle stimulation results in robust expansion of memory-like Natural Killer cells with enhanced survival

Jeremiah L. Oyer et al.

CANCER RESEARCH (2023)

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Article Hematology

Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant

Jeffrey J. Bednarski et al.

Summary: In this study, memory-like NK cells (ML NK cells) were used to treat relapsed pediatric and young adult patients with AML after HCT. The results showed that ML NK cells can persist and exhibit potent anti-leukemic activity in a compatible post-HCT immune environment. The combination of DLI and ML NK cells provides a novel immunotherapy platform for relapsed AML.

BLOOD (2022)

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Article Hematology

Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy

Melissa M. Berrien-Elliott et al.

Summary: Using IL-15 for allogeneic cellular therapy may paradoxically limit therapeutic efficacy as it accelerates CD8 T-cell activation, leading to rejection of donor NK cells.

BLOOD (2022)

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Article Oncology

Characteristics and clinical correlation of TIM-3 and PD-1/PD-L1 expressions in leukemic cells and tumor microenvironment in newly diagnosed acute myeloid leukemia

Thunyamon Chajuwan et al.

Summary: A study of bone marrow in newly diagnosed AML patients revealed that high levels of TIM-3 on AML blasts were associated with induction failure, while high TIM-3 levels on NK cells were correlated with complete remission status. Few PD-L1 positive AML blasts and PD-1/PD-L1 positive NK cells were observed, and double positive PD-1 and TIM-3 T cells were rarely detected.

LEUKEMIA & LYMPHOMA (2022)

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Article Cell Biology

Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia

Melissa M. Berrien-Elliott et al.

Summary: In a clinical trial for relapsed/refractory acute myeloid leukemia (AML), same-donor memory-like (ML) NK cell therapy supported by N-803 successfully augmented reduced-intensity conditioning (RIC) haploidentical hematopoietic cell transplantation (HCT). Donor ML NK cells had unique phenotypic and transcriptional profiles and exhibited enhanced ex vivo function compared to conventional NK cells.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Review Oncology

Importance of T, NK, CAR T and CAR NK Cell Metabolic Fitness for Effective Anti-Cancer Therapy: A Continuous Learning Process Allowing the Optimization of T, NK and CAR-Based Anti-Cancer Therapies

Adrien Krug et al.

Summary: Cancer treatments are rapidly evolving, with some novel drugs focusing on modifying immune cells to enhance their ability to kill tumors. However, the tumor microenvironment can limit the effectiveness of these immune cells by competing for nutrients. This article discusses strategies to overcome these limitations and improve the immune system's capacity to fight cancer.

CANCERS (2022)

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Article Oncology

Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis

Guanfang Liu et al.

Summary: AML, the most common blood cancer in adults, with high relapse and poor survival rate, can be targeted by NK cells through TIGIT blockade which enhances NK cell function. A high frequency of TIGIT(+)NK cells in AML patients is associated with poor prognosis, making TIGIT blockade a potential strategy for AML treatment.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

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Editorial Material Hematology

Memory NK cells to forget relapsed AML

Robin Parihar

Summary: In this study, memory-like natural killer (ML NK) cells were evaluated for their potential in treating relapsed acute myeloid leukemia (AML) patients after transplantation. The results show that ML NK cells hold promise in AML therapy, and serial assessments of blood and bone marrow provide new insights into their biology.

BLOOD (2022)

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Review Biochemistry & Molecular Biology

Transcriptional and Epigenetic Regulation of Gasdermins

Emilie Bourdonnay et al.

Summary: Gasdermins (GSDM) are a family of proteins that play important roles in cell death, immune response, disease susceptibility, and treatment response. The expression of GSDM genes is influenced by various factors and has been associated with diseases such as asthma, inflammatory bowel disease, and cancer.

JOURNAL OF MOLECULAR BIOLOGY (2022)

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Review Immunology

Cytokine-Induced Memory-Like NK Cells: From the Basics to Clinical Applications

Inigo Terren et al.

Summary: Natural killer (NK) cells play a key role in defense against viral infections and tumor cells. Recent research has shown that under certain conditions, NK cells can exhibit adaptive and memory-like features. These memory-like NK cells undergo genetic and metabolic changes, resulting in enhanced effector functions after a resting period. Due to their long persistence, these memory-like NK cells are potential candidates for cancer immunotherapy.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

Nina Lamers-Kok et al.

Summary: This review summarizes the clinical status of allogeneic NK cell-based therapies for hematological and solid tumors, discusses different cell sources, engineering methods, and combination therapies. It also reviews regulatory challenges and the competitive landscape, providing a comprehensive overview.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Hematology

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

Hartmut Doehner et al.

Summary: The 2010 and 2017 editions of the European LeukemiaNet recommendations for AML diagnosis and management are widely recognized. There have been major advances in our understanding of AML, including disease classification updates, improvements in genomic diagnostics, and the development of new therapeutic agents. This update includes a revised genetic risk classification, response criteria, and treatment recommendations.

BLOOD (2022)

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Review Oncology

Nanoparticle Enhancement of Natural Killer (NK) Cell-Based Immunotherapy

Dhanashree Murugan et al.

Summary: This paper reviews the role of natural killer (NK) cells in killing tumor cells and the receptors that can be targeted for signaling. It also highlights the potential of nanoparticles in activating NK cells and enhancing their cytotoxic activity against cancer.

CANCERS (2022)

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Article Multidisciplinary Sciences

Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia

Han Dong et al.

Summary: Acute myeloid leukemia (AML) is difficult to treat due to a lack of tumor-specific targets for immune-based therapies. Recent studies have shown that natural killer (NK) cells exhibit innate memory and enhanced antitumor activity when activated with IL-12 and IL-18. This study demonstrates that arming CIML NK cells with a neoepitope-specific CAR significantly improves their antitumor responses to NPM1-mutated AML and avoids off-target toxicity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Review Immunology

Overcoming tumor resistance mechanisms in CAR-NK cell therapy

Antonio Valeri et al.

Summary: Despite the successful results of autologous CAR-T cell therapy, CAR-NK immunotherapy offers a safer, faster, and cost-effective approach with no severe toxicities. However, resistance to CAR-NK cell therapy may arise due to various intrinsic or extrinsic mechanisms that affect NK cell function.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Chimeric Antigen Receptor Immunotherapy for Solid Tumors: Choosing the Right Ingredients for the Perfect Recipe

Luciano Castiello et al.

Summary: Despite success in hematology, chimeric antigen receptor T cell therapies have shown limited progress in treating solid tumors. Multiple factors, including the heterogeneity of solid tumors and difficulties in identifying reliable tumor antigens, contribute to this slower pace. Currently, different CAR therapies are being investigated, with varying construction types, engineered cells, and additional signals to overcome solid tumor barriers. Novel approaches are also being developed to address limitations seen in approved therapies. This review analyzes the advantages and challenges of these different approaches, considering both scientific evidence and manufacturing/regulatory issues for further clinical development.

CANCERS (2022)

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Review Cell Biology

The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: From biology to therapeutic targeting

Yongfeng Chen et al.

Summary: Acute myeloid leukemia (AML) patients often develop chemotherapeutic resistance and relapse, primarily due to the presence of leukemic stem cells (LSCs). LSCs possess stem cell properties and can adapt to the action of chemotherapy in the bone marrow microenvironment (BMM). Understanding the relationship between LSCs and the BMM can improve treatment outcomes for AML.

CELL DEATH DISCOVERY (2022)

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Article Hematology

Allogeneic natural killer cell therapy

Melissa M Berrien-Elliott et al.

BLOOD (2022)

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Meeting Abstract Hematology

Innate Cell Engager AFM13 Combined with Preactivated and Expanded Cord Blood-Derived NK Cells for Patients with Double Refractory CD30+Lymphoma

Yago Nieto et al.

BLOOD (2022)

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Review Oncology

Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology

Ryan J. Stubbins et al.

Summary: This article reviews the treatment and management strategies for acute myeloid leukemia (AML), focusing on individualized intensive therapy, recently approved novel therapies, and post-remission therapy selection. It also discusses the management of relapsed and refractory AML patients, targeted treatment, and allogeneic stem cell transplant. Non-intensive treatment for older and unfit patients, as well as the integration of palliative care in AML management, are also reviewed.

CURRENT ONCOLOGY (2022)

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Article Medicine, Research & Experimental

Expansion, persistence, and efficacy of donor memory- like NK cells infused for posttransplant relapse

Roman M. Shapiro et al.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Allergy

Glucocorticoids and the cytokines IL-12, IL-15, and IL-18 present in the tumor microenvironment induce PD-1 expression on human natural killer cells

Linda Quatrini et al.

Summary: The induction of PD-1 expression on human NK cells in the tumor setting is dependent on the cooperative action of glucocorticoids and cytokines, leading to enhanced mRNA translation and increased PD-1 levels.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Hematology

Chimeric antigen receptor (CAR) natural killer (NK)-cell therapy: leveraging the power of innate immunity

Hind Rafei et al.

Summary: CAR T cells are an emerging cancer treatment with limitations including toxicity, manufacturing complexity, and cost. NK cells have potential as a safer and more accessible source for CAR therapy, and genetic engineering of NK cells to express CAR is showing promising results in preclinical studies and clinical trials.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Hematology

A Phase 1 Study of NKX019, a CD19 Chimeric Antigen Receptor Natural Killer (CAR NK) Cell Therapy, in Subjects with B-Cell Malignancies

Michael Dickinson et al.

BLOOD (2021)

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Review Oncology

Acute myeloid leukemia: current progress and future directions

Hagop Kantarjian et al.

Summary: Advancements in understanding and therapy of AML have been rapid, with targeted therapies such as venetoclax and FLT3 inhibitors being approved for various indications. Expertise is crucial in managing the complexity of AML treatment, tailored to the specific subentities for optimal outcomes.

BLOOD CANCER JOURNAL (2021)

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Review Cell & Tissue Engineering

Cytokine-induced memory-like natural killer cells for cancer immunotherapy

Mubin Tarannum et al.

Summary: NK cells can exhibit memory-like features, altering their lifespan and function through cytokine-induced methods to enhance anticancer effects. Current research indicates that these memory-like NK cells have great potential for clinical applications.

STEM CELL RESEARCH & THERAPY (2021)

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Article Oncology

Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies

Lucila N. Kerbauy et al.

Summary: The study suggests that using bispecific engagers and cytokine pre-activation can enhance NK-cell cytotoxicity against NK-resistant cancers. Additionally, there are differences in treatment response based on the source of NK cells.

CLINICAL CANCER RESEARCH (2021)

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Review Immunology

Current Perspectives on Off-The-Shelf Allogeneic NK and CAR-NK Cell Therapies

Erica L. Heipertz et al.

Summary: Natural killer (NK) cells are a crucial part of the immune system, with the ability to kill virally infected and malignant cells. Current research is focused on testing the efficacy of NK cell therapy for cancer and exploring the use of CAR-NK for treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Meeting Abstract Oncology

DEVELOPMENT OF WU-NK-101, A FEEDER CELL-FREE EXPANDED ALLOGENEIC MEMORY NK CELL PRODUCT WITH POTENT ANTI-TUMOR ACTIVITY

Ryan Sullivan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

Emerging agents and regimens for AML

Hongtao Liu

Summary: Recent advancements in AML treatment have led to expanded therapeutic options for patients through genomic and molecular research, including targeted therapies, immunotherapy, and combinations of therapeutic agents from different classes, resulting in improved survival rates.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Letter Oncology

Autologous CD33-CAR-T cells for treatment of relapsed/refractory acute myelogenous leukemia

Francesco Paolo Tambaro et al.

LEUKEMIA (2021)

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Article Hematology

Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity

Nidhi Kedia-Mehta et al.

Summary: NK cells have the ability to rapidly kill cancer cells and produce cytokines, and their effector functions can be enhanced through metabolic regulation, potentially increasing their effectiveness in cancer immunotherapy. NK cells from individuals with obesity exhibit metabolic defects, resulting in impaired training responses, which could impact their therapeutic efficacy in immunotherapy.

BLOOD ADVANCES (2021)

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Editorial Material Immunology

NK cell memory: discovery of a mystery

Ulrich H. von Andrian

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Metabolic changes of Interleukin-12/15/18-stimulated human NK cells

Inigo Terren et al.

Summary: NK cells acquire memory-like properties following stimulation with IL-12, IL-15 and IL-18, and these cytokine-induced memory-like NK cells have shown promising potential in cancer immunotherapy. NK cells modulate their metabolism in response to cytokine-stimulation, with a link between metabolism and cellular functions.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Cytokine-Induced Memory-Like NK Cells with High Reactivity against Acute Leukemia Blasts and Solid Tumor Cells Suitable for Adoptive Immunotherapy Approaches

Matteo Tanzi et al.

Summary: Strategies to enhance anti-tumor responses in patients with poor prognosis have been explored, with NK cells showing advantage in killing tumor cells. In vitro activation of NK cells to generate cells with memory-like properties, ensuring long-lasting function in vivo, demonstrates potential therapeutic efficacy.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Recent Advances to Augment NK Cell Cancer Immunotherapy Using Nanoparticles

Kwang-Soo Kim et al.

Summary: NK cell cancer immunotherapy plays a unique role but faces challenges such as the immune-suppressive tumor microenvironment, low activity of NK cells, and limited contact frequency of NK cells with tumor cells. Innovative strategies are needed to advance NK cell cancer immunotherapy.

PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

Natural killer (NK) cell-based immunotherapies and the many faces of NK cell memory: A look into how nanoparticles enhance NK cell activity

Idoia Mikelez-Alonso et al.

Summary: NK cells are lymphocytes with potent antitumor and antiviral functions, exhibiting memory-like responses. Various NK cell-based immunotherapies have been developed, with nanotechnology considered as an attractive option to enhance NK cell effector functions.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Michelle K. Becker-Hapak et al.

Summary: NK cells show promise as a cellular therapy for cancer, but challenges in production of required reagents exist. A novel HFPC platform was developed to activate NK cells against cancer, showing potential for advancement in clinical GMP-grade memory-like NK cell production.

CANCER IMMUNOLOGY RESEARCH (2021)

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Review Immunology

Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment

Natasha Mupeta Kaweme et al.

Summary: NK cells play a crucial role in cancer immunotherapy, with various sources and innovative methods being explored to enhance therapeutic NK cell generation and overcome immunosuppressive factors in the tumor microenvironment for improved anti-tumor effects.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer

Irina Buckle et al.

Summary: The discovery of immune checkpoints has revolutionized cancer therapy, leading to early clinical success with monoclonal antibodies against PD-1 and CTLA-4. While traditionally focused on T cells, there is now increasing evidence that immune checkpoint molecules also play a role in regulating Natural Killer (NK) cell responses to cancer. This review provides insights into the potential therapeutic targets among NK cell inhibitory receptors and their implications for cancer treatment.

CANCERS (2021)

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Review Oncology

The Advances and Challenges of NK Cell-Based Cancer Immunotherapy

Synat Kang et al.

Summary: NK cells have the ability to lyse tumor targets, but lack specificity. Engineering NK cells with TCR can increase their reactivity and recognition specificity towards tumor cells, which is significant for cancer immunotherapy.

CURRENT ONCOLOGY (2021)

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Article Oncology

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

Jana Rakova et al.

Summary: Accumulating evidence suggests that TIM-3 expression in NK cells is correlated with improved functional licensing and superior effector functions in AML patients, making NK cell frequency and TIM-3 expression relevant prognostic biomarkers of active immunity against AML.

ONCOIMMUNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

NK cells for cancer immunotherapy

Noriko Shimasaki et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Oncology

Advances in the Treatment of Acute Myeloid Leukemia: New Drugs and New Challenges

Nicholas J. Short et al.

CANCER DISCOVERY (2020)

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Review Medicine, Research & Experimental

Immune escape and immunotherapy of acute myeloid leukemia

Luca Vago et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Immunology

NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?

Victoria Stary et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Oncology

Treatment of Relapsed Acute Myeloid Leukemia

Felicitas Thol et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2020)

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Article Hematology

CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas

Margery Gang et al.

BLOOD (2020)

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Article Multidisciplinary Sciences

Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy

Kin Man Au et al.

SCIENCE ADVANCES (2020)

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Review Cell Biology

Checkpoint Inhibitors and Engineered Cells: New Weapons for Natural Killer Cell Arsenal Against Hematological Malignancies

Massimo Giuliani et al.

CELLS (2020)

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Article Biology

Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations

Patricia J. Ahl et al.

COMMUNICATIONS BIOLOGY (2020)

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Review Cell Biology

Research Progress on NK Cell Receptors and Their Signaling Pathways

Yingying Chen et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Immunology

The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies

Tobias Bald et al.

NATURE IMMUNOLOGY (2020)

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Article Hematology

Modulating NK cell metabolism for cancer immunotherapy

Inigo Terren et al.

SEMINARS IN HEMATOLOGY (2020)

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Article Oncology

Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia

Melissa M. Berrien-Elliott et al.

CANCER DISCOVERY (2020)

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Article Immunology

A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses

Victoria Stary et al.

SCIENCE IMMUNOLOGY (2020)

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Review Oncology

Natural killer cell-based immunotherapy for acute myeloid leukemia

Jing Xu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Oncology

Advances in Acute Myeloid Leukemia: Recently Approved Therapies and Drugs in Development

Michele Stanchina et al.

CANCERS (2020)

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Article Medicine, General & Internal

Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study

Tereza Dekojova et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Oncology

New directions for emerging therapies in acute myeloid leukemia: the next chapter

Naval Daver et al.

BLOOD CANCER JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy

Yuqing Cao et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Immunology

Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells

Joshua Ghofrani et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2019)

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Review Immunology

What Defines NK Cell Functional Fate: Phenotype or Metabolism?

Sophie M. Poznanski et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

NK Cell Metabolism and Tumor Microenvironment

Inigo Terren et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Medicine, General & Internal

NK Cell Plasticity in Cancer

Sizhe Liu et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Meeting Abstract Hematology

Primary Human NK Cell Gene-Editing Reveals a Critical Role for NKG2A in Cytokine-Induced Memory-like NK Cell Responses

Melissa M. Berrien-Elliott et al.

BLOOD (2019)

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Meeting Abstract Hematology

Cytokine-Induced Memory-like (ML) NK Cells Persist for > 2 Months Following Adoptive Transfer into Leukemia Patients with a MHC-Compatible Hematopoietic Cell Transplant (HCT)

Jennifer A. Foltz et al.

BLOOD (2019)

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Article Oncology

Targeting of CXCR3 improves anti-myeloma efficacy of adoptively transferred activated natural killer cells

Valentina Bonanni et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Microbiology

Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens

Mihai G. Netea et al.

CELL HOST & MICROBE (2019)

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Review Oncology

Acute myeloid leukemia and NK cells: two warriors confront each other

Aroa Baragano Raneros et al.

ONCOIMMUNOLOGY (2019)

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Article Oncology

Novel Immunoregulatory Functions of IL-18, an Accomplice of TGF-β1

Beatrice Casu et al.

CANCERS (2019)

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Article Oncology

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

E. Liu et al.

LEUKEMIA (2018)

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Article Oncology

Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML

Andreas T. Bjorklund et al.

CLINICAL CANCER RESEARCH (2018)

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Review Oncology

Precision therapy for acute myeloid leukemia

Xue Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Article Immunology

Implication of Interleukin-12/15/18 and Ruxolitinib in the Phenotype, Proliferation, and Polyfunctionality of Human Cytokine-Preactivated Natural Killer Cells

Inigo Terren et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Meeting Abstract Oncology

Mass cytometry identifies the expansion, persistence, and immune checkpoints of adoptively transferred memory-like NK cells in patients with leukemia

Melissa M. Berrien-Elliott et al.

CANCER RESEARCH (2018)

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Article Immunology

Epigenetic control of innate and adaptive immune memory

Colleen M. Lau et al.

NATURE IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Memory formation and long-term maintenance of IL-7R alpha(+) ILC1s via a lymph node-liver axis

Xianwei Wang et al.

NATURE COMMUNICATIONS (2018)

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Review Immunology

Memory-Like NK Cells: Remembering a Previous Activation by Cytokines and NK Cell Receptors

Jens H. W. Pahl et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Oncology

TGFβ Imprinting During Activation Promotes Natural Killer Cell Cytokine Hypersecretion

Jennifer A. Foltz et al.

CANCERS (2018)

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Article Immunology

KIR downregulation by IL-12/15/18 unleashes human NK cells from KIR/HLA-I inhibition and enhances killing of tumor cells

Eva-Maria Ewen et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Chitosan nanoparticle-based delivery of fused NKG2D-IL-21 gene suppresses colon cancer growth in mice

Lunmei Tan et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Biochemistry & Molecular Biology

IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation

Evan Lusty et al.

MOLECULAR IMMUNOLOGY (2017)

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Review Immunology

Memory responses of natural killer cells

Clair D. Geary et al.

SEMINARS IN IMMUNOLOGY (2017)

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Review Immunology

Mechanisms of Immune Tolerance in Leukemia and Lymphoma

Emily K. Curran et al.

TRENDS IN IMMUNOLOGY (2017)

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Article Immunology

Natural Killer Defective Maturation Is Associated with Adverse Clinical Outcome in Patients with Acute Myeloid Leukemia

Anne-Sophie Chretien et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Immunology

Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity

Congcong Zhang et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Immunology

Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses

Moritz Rapp et al.

SCIENCE IMMUNOLOGY (2017)

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Article Hematology

Cytokine-Induced Memory-Like Differentiation Enhances Unlicensed Natural Killer Cell Antileukemia and FcγRIIIa-Triggered Responses

Julia A. Wagner et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2017)

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Meeting Abstract Oncology

Preclinical assessment of PM21-particle expanded natural killer cells for ovarian cancer treatment

Jeremiah Oyer et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Medicine, Research & Experimental

Overexpression of CD158 and NKG2A Inhibitory Receptors and Underexpression of NKG2D and NKp46 Activating Receptors on NK Cells in Acute Myeloid Leukemia

Daniela Sandoval-Borrego et al.

ARCHIVES OF MEDICAL RESEARCH (2016)

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Article Oncology

Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Antonio Curti et al.

CLINICAL CANCER RESEARCH (2016)

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Article Cell & Tissue Engineering

Natural killer cells stimulated with PM21 particles expand and biodistribute in vivo: Clinical implications for cancer treatment

Jeremiah L. Oyer et al.

CYTOTHERAPY (2016)

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Article Medicine, Research & Experimental

MicroRNA-29b mediates altered innate immune development in acute leukemia

Bethany L. Mundy-Bosse et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Immunology

The aryl hydrocarbon receptor is required for the maintenance of liver-resident natural killer cells

Luhua H. Zhang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Immunology

Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide

Sharline Madera et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Immunology

Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells

Sinead E. Keating et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Cell Biology

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

Rizwan Romee et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Review Immunology

Harnessing NK Cell Memory for Cancer Immunotherapy

Todd A. Fehniger et al.

TRENDS IN IMMUNOLOGY (2016)

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Article Biotechnology & Applied Microbiology

TriKEs and BiKEs join CARs on the cancer immunotherapy highway

Szun Szun Tay et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)

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Article Oncology

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing

Conor J. Kearney et al.

ONCOIMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Metabolic regulation of natural killer cells

David K. Finlay

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

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Article Immunology

IL-12/15/18-preactivated NKcells suppress GvHD in a mouse model of mismatched hematopoietic cell transplantation

Christian M. Hueber et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

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Article Immunology

BNIP3-and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory

Timothy E. O'Sullivan et al.

IMMUNITY (2015)

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Review Immunology

Natural Killer Cell Memory

Timothy E. O'Sullivan et al.

IMMUNITY (2015)

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Article Immunology

Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production

Molly P. Keppel et al.

JOURNAL OF IMMUNOLOGY (2015)

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Review Immunology

Human Cytokine-Induced Memory-Like Natural Killer Cells

Melissa M. Berrien-Elliott et al.

JOURNAL OF INNATE IMMUNITY (2015)

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Article Immunology

Antigen-specific NK cell memory in rhesus macaques

R. Keith Reeves et al.

NATURE IMMUNOLOGY (2015)

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Article Rheumatology

Inhibition of Natural Killer Cell Cytotoxicity by Interleukin-6: Implications for the Pathogenesis of Macrophage Activation Syndrome

Loredana Cifaldi et al.

ARTHRITIS & RHEUMATOLOGY (2015)

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Article Genetics & Heredity

Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia

A. Baragano Raneros et al.

GENES AND IMMUNITY (2015)

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Article Hematology

Preactivation with IL-12, IL-15, and IL-18 Induces CD25 and a Functional High-Affinity IL-2 Receptor on Human Cytokine-Induced Memory-like Natural Killer Cells

Jeffrey W. Leong et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2014)

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Article Hematology

Leukemia-induced phenotypic and functional defects in natural killer cells predict failure to achieve remission in acute myeloid leukemia

Kate Stringaris et al.

HAEMATOLOGICA (2014)

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Article Medicine, Research & Experimental

IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion

Alexander Roelle et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Article Immunology

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

Raymond P. Donnelly et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Medicine, Research & Experimental

A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells

Uwe Reusch et al.

MABS (2014)

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Article Hematology

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

Rizwan Romee et al.

BLOOD (2013)

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Review Immunology

Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy

Isabela Pedroza-Pacheco et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2013)

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Article Immunology

Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-α, interferon-γ and interleukin-12

Monika Majewska-Szczepanik et al.

IMMUNOLOGY (2013)

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Article Immunology

Murine NK Cell Intrinsic Cytokine-Induced Memory-like Responses Are Maintained following Homeostatic Proliferation

Molly P. Keppel et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Virology

Human Cytomegalovirus-Induced NKG2Chi CD57hi Natural Killer Cells Are Effectors Dependent on Humoral Antiviral Immunity

Zeguang Wu et al.

JOURNAL OF VIROLOGY (2013)

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Review Immunology

Natural killer cells: walking three paths down memory lane

Gundula Min-Oo et al.

TRENDS IN IMMUNOLOGY (2013)

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Article Engineering, Biomedical

The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles

Eue-Soon Jang et al.

BIOMATERIALS (2012)

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Article Hematology

Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function

Bree Foley et al.

BLOOD (2012)

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Article Hematology

Cytokine activation induces human memory-like NK cells

Rizwan Romee et al.

BLOOD (2012)

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Article Cell Biology

Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients

Beatriz Sanchez-Correa et al.

IMMUNOLOGY AND CELL BIOLOGY (2012)

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Article Immunology

Proinflammatory cytokine signaling required for the generation of natural killer cell memory

Joseph C. Sun et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

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Article Immunology

Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors

Jing Ni et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

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Article Immunology

The Bone Marrow Functions as the Central Site of Proliferation for Long-Lived NK Cells

Mary J. G. van Helden et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Immunology

Comprehensive Analysis of NKG2D Ligand Expression and Release in Leukemia: Implications for NKG2D-Mediated NK Cell Responses

Julia Hilpert et al.

JOURNAL OF IMMUNOLOGY (2012)

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Review Oncology

Natural killer cell immune escape in acute myeloid leukemia

E. Lion et al.

LEUKEMIA (2012)

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Article Multidisciplinary Sciences

Genital HSV-2 Infection Induces Short-Term NK Cell Memory

Mohamed F. Abdul-Careem et al.

PLOS ONE (2012)

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Article Hematology

Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients

Antonio Curti et al.

BLOOD (2011)

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Article Oncology

Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4

Dawn Holt et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2011)

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Article Oncology

CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia

S. J. Coles et al.

LEUKEMIA (2011)

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Article Multidisciplinary Sciences

Expansion of a unique CD57+ NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

Sandra Lopez-Verges et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Microbiology

Correction: Thy1+Nk Cells from Vaccinia Virus-Primed Mice Confer Protection against Vaccinia Virus Challenge in the Absence of Adaptive Lymphocytes

Geoffrey O. Gillard et al.

PLoS Pathogens (2011)

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Article Oncology

In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors

Celine Berthon et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2010)

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Article Immunology

Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses

Silke Paust et al.

NATURE IMMUNOLOGY (2010)

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Article Gastroenterology & Hepatology

Myeloid Derived Suppressor Cells Inhibit Natural Killer Cells in Patients with Hepatocellular Carcinoma via the NKp30 Receptor

Bastian Hoechst et al.

HEPATOLOGY (2009)

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Article Immunology

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-beta 1

Hequan Li et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Immunology

IL-12-Dependent Inducible Expression of the CD94/NKG2A Inhibitory Receptor Regulates CD94/NKG2C+ NK Cell Function

Andrea Saez-Borderias et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Multidisciplinary Sciences

Adaptive immune features of natural killer cells

Joseph C. Sun et al.

NATURE (2009)

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Article Multidisciplinary Sciences

Cytokine-induced memory-like natural killer cells

Megan A. Cooper et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Review Immunology

RUNX proteins in transcription factor networks that regulate T-cell lineage choice

Amelie Collins et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Article Immunology

TGF-β utilizes SMAD3 to inhibit CD16-mediated IFN-γ production and antibody-dependent cellular cytotoxicity in human NK cells

Rossana Trotta et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Hematology

Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host

Cunren Liu et al.

BLOOD (2007)

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Article Multidisciplinary Sciences

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Ye Zheng et al.

NATURE (2007)

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Article Hematology

Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction

Cyril Fauriat et al.

BLOOD (2007)

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Article Rheumatology

The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors

Casimir de Rham et al.

ARTHRITIS RESEARCH & THERAPY (2007)

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Article Immunology

Pro- and antiinflammatory cytokine signaling: Reciprocal antagonism regulates interferon-gamma production by human natural killer cells

Jianhua Yu et al.

IMMUNITY (2006)

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Article Immunology

T cell- and B cell-independent adaptive immunity mediated by natural killer cells

JG O'Leary et al.

NATURE IMMUNOLOGY (2006)

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Article Hematology

Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts

M Gumá et al.

BLOOD (2006)

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Article Hematology

Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias

P Nowbakht et al.

BLOOD (2005)

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Article Hematology

Imprint of human cytomegalovirus infection on the NK ceH receptor repertoire

M Gumá et al.

BLOOD (2004)

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Article Hematology

Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

HR Salih et al.

BLOOD (2003)

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Article Multidisciplinary Sciences

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors:: Consequences for the NK-mediated killing of dendritic cells

R Castriconi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Review Immunology

Interleukin-12 and the regulation of innate resistance and adaptive immunity

G Trinchieri

NATURE REVIEWS IMMUNOLOGY (2003)

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Article Biochemistry & Molecular Biology

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development

I Taniuchi et al.

CELL (2002)

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Article Multidisciplinary Sciences

STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

A Morinobu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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Article Multidisciplinary Sciences

Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells

O Mandelboim et al.

NATURE (2001)

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