4.4 Review

The effects of treating GERD on the outcomes of otitis media with effusion: A systematic review and meta-analysis

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Article Medicine, General & Internal

Factors affecting the occurrence of otitis media with effusion in preschool and elementary school children: a comparative cross-sectional study

Ratna Dwi Restuti et al.

Summary: This study aimed to identify the risk factors for otitis media with effusion (OME) and found a significant relationship between laryngopharyngeal reflux (LPR) and OME. Adenoid hypertrophy and allergic rhinitis showed no significant correlation with OME.

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Summary: The study found that 58% of children with persistent OME had GERD. After anti-reflux treatment, 52% of children showed improvement in persistent OME symptoms. Therefore, GERD should be considered in patients with persistent OME, and the use of proton pump inhibitors can avoid unnecessary surgical treatments.

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The Relationship Between Otitis Media With Effusion and Gastroesophageal Reflux Disease: A Meta-analysis

Zeng-Hong Wu et al.

Summary: The study revealed a significant association between otitis media with effusion (OME) and gastroesophageal reflux disease (GERD), with a pooled odds ratio of 4.52. The random-effects model was used due to significant heterogeneity among studies, with no significant publication bias observed.

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Correlation of pathogenic effects of laryngopharyngeal reflux and bacterial infection in COME of children

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Summary: The study found that bacterial infection and laryngopharyngeal reflux may act synergistically in the pathogenesis of chronic otitis media with effusion, providing the first evidence that LPR and bacterial infection may synergistically cause COME.

ACTA OTO-LARYNGOLOGICA (2021)

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Association of gastroesophageal reflux disease with increased risk of chronic otitis media with effusion in adults A nationwide population-based cohort study

Cha Dong Yeo et al.

Summary: The study found that individuals with gastroesophageal reflux disease have a higher risk of developing chronic otitis media compared to those without the disease, especially when comorbidities such as allergic rhinitis, asthma, or chronic rhinosinusitis are present.

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Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Fernando M. Calatayud-Saez et al.

Summary: The study found that the Traditional Mediterranean Diet can help regulate inflammation and immunity, reduce disease occurrences in patients with otitis media with effusion, and the satisfaction of the participants and families with the diet program was very high.

NUTRIENTS (2021)

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Prevalence and associated risk factors of recurrent otitis media with effusion in children in Upper Egypt

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Otitis media with effusion in adults with patulous Eustachian tube

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A Clinical Trial of Proton Pump Inhibitors to Treat Children with Chronic Otitis Media with Effusion

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Role of Laryngopharyngeal Reflux in the Pathogenesis of Otitis Media with Effusion

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The Prevalence Rate of Helicobacter pylori Infection in, Chronic Otitis Media With Effusion Patients

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Gastroesophageal Reflux Disease in Children With Chronic Otitis Media With Effusion

Fatih Yuksel et al.

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Role of GERD in Children with Otitis Media with Effusion

Surendran Nair et al.

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A Prospective Study of the Effect of Gastroesophageal Reflux Disease Treatment on Children With Otitis Media

Edward D. McCoul et al.

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Bile Acids Identified in Middle Ear Effusions of Children with otitis Media with Effusion

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Agostino Serra et al.

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Prediction of gastroesophageal reflux in otitis media with effusion in adults

Michihiko Sone et al.

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