Characterization of nanodisc-forming peptides for membrane protein studies

Article Chemistry, Medicinal

Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins

Bankala Krishnarjuna et al.

Summary: Elevenin-Vc1, a peptide found in the venom of Conus victoriae, was shown to induce hyperactivity in mice. However, it was found to be inactive at various human nAChR subtypes.

MARINE DRUGS (2023)

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Article Biochemistry & Molecular Biology

Role of membrane mimetics on biophysical EPR studies of membrane proteins

Indra D. Sahu et al.

Summary: Biological membranes are crucial for maintaining the stability of membrane proteins in a functional state. However, there is no universal membrane mimetic system available that can effectively solubilize all membrane proteins for biophysical EPR studies while preserving their functional integrity. Efforts are needed to optimize sample conditions and improve the quality of EPR data for membrane proteins in order to obtain meaningful information on their structural dynamics. This mini-review discusses the importance of membrane mimetics in biophysical EPR measurements and presents recent progress in this field.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2023)

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Article Chemistry, Physical

Enhancing the stability and homogeneity of non-ionic polymer nanodiscs by tuning electrostatic interactions

Bankala Krishnarjuna et al.

Summary: The nanodisc technology is widely used in structural studies on membrane proteins and drug delivery. The development of synthetic polymer nanodiscs and the recent discovery of non-ionic inulin-based polymers have expanded the range of applications for nanodiscs. This study investigates the size stability and homogeneity of non-ionic polymer nanodiscs using different biophysical methods, demonstrating the importance of electrostatic interactions in tuning the solubility, stability, and size homogeneity of these nanodiscs.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

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Article Chemistry, Multidisciplinary

Cellular Nanodiscs Made from Bacterial Outer Membrane as a Platform for Antibacterial Vaccination

Ilkoo Noh et al.

Summary: Vaccination with nanovaccines based on bacterial outer membrane has shown promising results in protecting against antibiotic-resistant infections. The cellular nanodiscs developed in this study effectively interact with antigen-presenting cells and can efficiently transport to lymph nodes. In a murine model, the nanovaccine elicits potent immune responses and confers protection against subsequent lung infection.

ACS NANO (2023)

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Article Polymer Science

Sulfonated polystyrenes: pH and Mg2+-insensitive amphiphilic copolymers for detergent-free membrane protein isolation

Miroslav Janata et al.

Summary: Amphiphilic polymers are widely used in the isolation and functional studies of membrane proteins. This study addressed the limitations of carboxylate groups in these polymers by replacing them with more acidic sulfonate groups. The newly synthesized copolymers solubilized membranes and liposomes, and remained soluble at low pH and in the presence of Mg2+ ions.

EUROPEAN POLYMER JOURNAL (2023)

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Article Multidisciplinary Sciences

Immunochemical characterisation of styrene maleic acid lipid particles prepared from Mycobacterium tuberculosis plasma membrane

Sudhir Sinha et al.

Summary: Styrene maleic acid lipid particles (SMALPs) were utilized to prepare and characterize membrane proteins of Mycobacterium tuberculosis (Mtb). These nanoparticles contained inner membrane protein PRA, membrane-associated proteins PstS1, LpqH and Ag85, and lipoglycan LAM. Peripheral membrane proteins Acr and PspA were excluded. Additionally, immune responses indicated that only MtM-SMALPs could induce the production of TNF-alpha.

PLOS ONE (2023)

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Review Chemistry, Multidisciplinary

Advances in NMR Spectroscopy of Weakly Aligned Biomolecular Systems

Sai Chaitanya Chiliveri et al.

Summary: The measurement and application of residual dipolar couplings in solution NMR studies of biological macromolecules has been well established, offering precise information for understanding the impact of molecular flexibility on protein function. Despite its underutilization, recent developments have enabled accurate measurement of RDCs in larger systems, signaling a shift in focus towards gaining improved understanding of protein function.

CHEMICAL REVIEWS (2022)

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Article Multidisciplinary Sciences

A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting in mammals

David A. Eagles et al.

Summary: This study discovered a peptide toxin, MIITX2-Mg1a, in the venom of the Australian giant red bull ant that mimics vertebrate epidermal growth factor. It acts as a potent agonist of the mammalian EGF receptor ErbB1, causing long-lasting hypersensitivity in mice.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Chemistry, Physical

The interaction of styrene maleic acid copolymers with phospholipids in Langmuir monolayers, vesicles and nanodiscs; a structural study

Stephen C. L. Hall et al.

Summary: This study investigates the dynamic behavior of nanodiscs with different membrane charges and polymer chemistry. The findings reveal that in the presence of external lipids, polymer chains embed throughout lipid membranes, and nanodiscs exchange lipids and polymer with monolayers.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Improvement of Thermal Stability of Amphipathic Peptide-Phospholipid Nanodiscs via Lateral Association of ?-Helices by Disulfide Cross-Linking

Chiharu Anada et al.

Summary: Amphipathic alpha-helical peptides can form nanodiscs with phospholipids, and cross-linking of peptides can stabilize the nanodisc structures against the phase transition of lipid bilayers. This study provides insights into the importance of lateral association of two alpha-helices for stable nanodiscs, which can be helpful in developing more stable nanoparticles with membrane proteins in the future.

LANGMUIR (2022)

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Article Biophysics

Aligned peptoid-based macrodiscs for structural studies of membrane proteins by oriented-sample NMR

Azamat R. Galiakhmetov et al.

Summary: The development of a robust, uniform, and magnetically orientable lipid mimetic is crucial for solid-state NMR studies of macroscopically aligned membrane proteins. A new lipid membrane mimetic based on peptoid belts has been reported, demonstrating lower polydispersity, greater flexibility, and detergent-free properties compared to conventional bicelles and peptide-based macrodiscs.

BIOPHYSICAL JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Polymer-Nanodiscs as a Novel Alignment Medium for High-Resolution NMR-Based Structural Studies of Nucleic Acids

Bankala Krishnarjuna et al.

Summary: In this study, polymer-based nanodiscs were used to measure RDCs from nucleic acids. The nanodiscs were characterized and their alignment stability was confirmed. RDCs from a labeled nucleic acid molecule were successfully measured using the aligned nanodiscs. This demonstrates the potential of SMA-EA-based lipid-nanodiscs for structural and dynamical studies of nucleic acids.

BIOMOLECULES (2022)

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Article Multidisciplinary Sciences

Mechanisms of membrane protein crystallization in 'bicelles'

Tatiana N. Murugova et al.

Summary: Despite remarkable progress in LCP and 'bicelle' crystallization, the lack of structural information remains a bottleneck in membrane protein research. This study uses small-angle scattering to investigate the evolution of the bicelle crystallization matrix during MP crystal growth and reveals the mechanisms of bicelle MP crystallization, providing support for rational design of crystallization.

SCIENTIFIC REPORTS (2022)

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Review Biochemistry & Molecular Biology

Detergent-Free Isolation of Membrane Proteins and Strategies to Study Them in a Near-Native Membrane Environment

Bankala Krishnarjuna et al.

Summary: Atomic-resolution structural studies of membrane-associated proteins and peptides in a membrane environment are important for understanding their biological function and disease pathology. Recent advancements in NMR spectroscopy, cryoEM approaches, and the development of novel membrane mimetics have overcome the complexity of the cell membrane and enabled reconstitution and investigation of membrane proteins.

BIOMOLECULES (2022)

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Article Chemistry, Analytical

Non-Ionic Inulin-Based Polymer Nanodiscs Enable Functional Reconstitution of a Redox Complex Composed of Oppositely Charged CYP450 and CPR in a Lipid Bilayer Membrane

Bankala Krishnarjuna et al.

Summary: This study reports the successful functional reconstitution of a membrane-bound redox complex in non-ionic inulin-based polymer nanodiscs. The nanodiscs have a higher phase-transition temperature and can align in an externally applied magnetic field. These findings suggest that non-ionic polymer nanodiscs can be used for studying the function and structures of various membrane proteins/complexes.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Electroneutral Polymer Nanodiscs Enable Interference-Free Probing of Membrane Proteins in a Lipid-Bilayer Environment

David Glueck et al.

Summary: Membrane proteins can be examined in near-native lipid-bilayer environments with the use of polymer-encapsulated nanodiscs. The creation of electroneutral nanodiscs enables new insights into protein-lipid interactions.

SMALL (2022)

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Article Biochemistry & Molecular Biology

Bicelles and nanodiscs for biophysical chemistry

Erick J. Dufourc

Summary: Membrane nanoobjects such as Bicelles and Nanodiscs are important tools for studying biomembrane properties, providing various membranous platforms for structural biology research. Internal dynamics of these nanoobjects is similar to liposomes, offering potential for studying the 3D structure, topology, and dynamics of membrane proteins.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2021)

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Article Biochemistry & Molecular Biology

Influence of DIBMA Polymer Length on Lipid Nanodisc Formation and Membrane Protein Extraction

Lauren E. Ball et al.

Summary: Polymer-based lipid nanoparticles, such as DIBMA, have shown significant advancements in the study of membrane proteins. Research indicates that DIBMA exhibits excellent performance in lipid nanodisc formation and membrane protein extraction, with better solubilization efficiency and cleaner separation compared to SMA and commercially available DIBMA.

BIOMACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

A disulfide-stabilised helical hairpin fold in acrorhagin I: An emerging structural motif in peptide toxins

Bankala Krishnarjuna et al.

Summary: Acrorhagin I is a disulfide-rich peptide found in sea anemones, showing toxicity towards crabs but no activity on voltage-gated ion channels. The peptide's structure resembles a toxin from a marine worm, suggesting a recurring motif in disulfide-rich peptides in marine organisms. Metal ion interaction studies indicated potential modulation of its function by zinc and nickel.

JOURNAL OF STRUCTURAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs

Meng Zhang et al.

Summary: Recent studies have uncovered the complex interactions between neurotensin receptor 1, neurotensin, and G proteins in a lipid bilayer environment, revealing a more intricate network of protein-protein interactions compared to structures obtained in detergent micelles. These findings provide new insights into the modulation of complex formation by lipid membranes and propose an allosteric mechanism for GDP release in G protein activation.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Multisite interactions of prions with membranes and native nanodiscs

Michael Overduin et al.

Summary: Prions exhibit specific interactions with lipids, with structured binding elements mediating lipid recognition. Conserved motifs suggest a long evolutionary attachment of prions to membranes, providing stable interactions and complex orientations. Lipids play a protective role in resistance or susceptibility to prion disease, with copolymers allowing resolution of various prion states and potential applications in understanding neurodegenerative diseases.

CHEMISTRY AND PHYSICS OF LIPIDS (2021)

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Article Chemistry, Physical

Temperature- and composition-dependent conformational transitions of amphipathic peptide-phospholipid nanodiscs

Chiharu Anada et al.

Summary: The study explored the temperature- and composition-dependent structural changes of 18A-phosphatidylcholine complexes. It was found that above the gel-to-liquid-crystalline phase transition temperature, nanodiscs increased in size, forming enlarged nanodiscs and a lamellar phase. Further increase in temperature induced the formation of lipid vesicles. These transformations were explained using a transition model based on the migration of the peptide from the rim of the nanodiscs to the liquid-crystalline bilayer phase.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Structural biology of endogenous membrane protein assemblies in native nanodiscs

Chanelle J. Brown et al.

Summary: The development of amphiphilic copolymers has allowed the solubilization of integral membrane proteins into native nanodiscs, providing insights into their structures and functions. This breakthrough has established biological membrane:protein assemblies as fundamental units of cellular membranes, and various methods including cryo-EM and NMR spectroscopy have been utilized for the characterization of transmembrane proteins within these nanodiscs.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Factors influencing the solubilization of membrane proteins from Escherichia coli membranes by styrene-maleic acid copolymers

Adrian H. Kopf et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

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Article Biochemistry & Molecular Biology

Simple Derivatization of RAFT-Synthesized Styrene-Maleic Anhydride Copolymers for Lipid Disk Formulations

Kevin M. Burridge et al.

BIOMACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

Mechanical Properties Determination of DMPC, DPPC, DSPC, and HSPC Solid-Ordered Bilayers

Dominik Drabik et al.

LANGMUIR (2020)

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Article Biochemical Research Methods

Dark, Ultra-Dark and Ultra-Bright Nanodiscs for membrane protein investigations

Mark A. McLean et al.

ANALYTICAL BIOCHEMISTRY (2020)

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Article Biology

Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

Tone Bengtsen et al.

ELIFE (2020)

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Article Chemistry, Physical

Adsorption of a styrene maleic acid (SMA) copolymer-stabilized phospholipid nanodisc on a solid-supported planar lipid bilayer

Stephen C. L. Hall et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Bicelles Rich in both Sphingolipids and Cholesterol and Their Use in Studies of Membrane Proteins

James M. Hutchison et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Biochemistry & Molecular Biology

Nanodisc scaffold peptide (NSPr) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs

Bryan Neumann et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Article Biochemistry & Molecular Biology

Membrane proteins in magnetically aligned phospholipid polymer discs for solid-state NMR spectroscopy

Sang Ho Park et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

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Article Chemistry, Multidisciplinary

The Single Disulfide-Directed β-Hairpin Fold: Role of Disulfide Bond in Folding and Effect of an Additional Disulfide Bond on Stability

Balasubramanyam Chittoor et al.

AUSTRALIAN JOURNAL OF CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Solid-state NMR structural investigations of peptide-based nanodiscs and of transmembrane helices in bicellar arrangements

Evgeniy S. Salnikov et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2019)

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Review Biochemistry & Molecular Biology

Nanodiscs bounded by styrene-maleic acid allow trans-cis isomerization of enclosed photoswitches of azobenzene labeled lipids

J. J. Dominguez Pardo et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2019)

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Article Biochemistry & Molecular Biology

NMR structure of a full-length single-pass membrane protein NRADD

Kirill D. Nadezhdin et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2019)

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Article Chemistry, Multidisciplinary

Magnetic Alignment of Polymer Macro-Nanodiscs Enables Residual-Dipolar-Coupling-Based High-Resolution Structural Studies by NMR

Thirupathi Ravula et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

Amphiphilic Polypeptoids Rupture Vesicle Bilayers To Form Peptoid-Lipid Fragments Effective in Enhancing Hydrophobic Drug Delivery

Yueheng Zhang et al.

LANGMUIR (2019)

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Article Pharmacology & Pharmacy

Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa

Khaled A. Elnahriry et al.

TOXICON (2019)

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Review Biochemistry & Molecular Biology

Memtein: The fundamental unit of membrane-protein structure and function

Michael Overduin et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2019)

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Article Biochemistry & Molecular Biology

Characterizing the structure of styrene-maleic acid copolymer-lipid nanoparticles (SMALPs) using RAFT polymerization for membrane protein spectroscopic studies

Benjamin D. Harding et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2019)

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Article Chemistry, Multidisciplinary

Cytochrome-P450-Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs

Carlo Barnaba et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Biochemistry & Molecular Biology

Modifying styrene-maleic acid co-polymer for studying lipid nanodiscs

Victoria Schmidt et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

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Article Biophysics

Supramolecular Organization of Apolipoprotein-A-I-Derived Peptides within Disc-like Arrangements

Evgeniy S. Salnikov et al.

BIOPHYSICAL JOURNAL (2018)

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Article Biophysics

Macrodiscs Comprising SMALPs for Oriented Sample Solid-State NMR Spectroscopy of Membrane Proteins

Jasmina Radoicic et al.

BIOPHYSICAL JOURNAL (2018)

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Article Chemistry, Physical

Real-Time Monitoring of Lipid Exchange via Fusion of Peptide Based Lipid-Nanodiscs

Thirupathi Ravula et al.

CHEMISTRY OF MATERIALS (2018)

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Review Chemistry, Physical

Picturing the Membrane-assisted Choreography of Cytochrome P450 with Lipid Nanodiscs

Carlo Barnaba et al.

CHEMPHYSCHEM (2018)

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Article Biochemistry & Molecular Biology

Covalently circularized nanodiscs; challenges and applications

Mahmoud L. Nasr et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra

Andras Micsonai et al.

NUCLEIC ACIDS RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK

Bankala Krishnarjuna et al.

PEPTIDES (2018)

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Article Pharmacology & Pharmacy

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp with an ShKT fold

Bankala Krishnarjuna et al.

TOXICON (2018)

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Article Biochemistry & Molecular Biology

Altering the edge chemistry of bicelles with peptoids

Helya Najafi et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2018)

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Article Biochemistry & Molecular Biology

Identification, chemical synthesis, structure, and function of a new KV1 channel blocking peptide from Oulactis sp.

Punnepalli Sunanda et al.

PEPTIDE SCIENCE (2018)

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Article Biophysics

Solubilization of lipids and lipid phases by the styrene-maleic acid copolymer

Juan J. Dominguez Pardo et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2017)

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Article Biochemical Research Methods

Covalently circularized nanodiscs for studying membrane proteins and viral entry

Mahmoud L. Nasr et al.

NATURE METHODS (2017)

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Article Biochemistry & Molecular Biology

Sensitivity enhancement for membrane proteins reconstituted in parallel and perpendicular oriented bicelles obtained by using repetitive cross-polarization and membrane-incorporated free radicals

Sophie N. Koroloff et al.

JOURNAL OF BIOMOLECULAR NMR (2017)

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Article Multidisciplinary Sciences

Fast Collisional Lipid Transfer Among Polymer-Bounded Nanodiscs

Rodrigo Cuevas Arenas et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

Thermotropic properties of phosphatidylcholine nanodiscs bounded by styrene-maleic acid copolymers

J. J. Dominguez Pardo et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2017)

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Article Biochemistry & Molecular Biology

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

Balasubramanyam Chittoor et al.

BIOCHEMISTRY (2017)

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Review Chemistry, Multidisciplinary

Nanodiscs in Membrane Biochemistry and Biophysics

Ilia G. Denisov et al.

CHEMICAL REVIEWS (2017)

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Article Chemistry, Multidisciplinary

Characterization of the Cytochromec Membrane-Binding Site Using Cardiolipin-Containing Bicelles with NMR

Hisashi Kobayashi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Chemistry, Multidisciplinary

Reconstitution of the Cytb5-CytP450 Complex in Nanodiscs for Structural Studies using NMR Spectroscopy

Meng Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Biochemistry & Molecular Biology

Membrane Fluidity Modulates Thermal Stability and Ligand Binding of Cytochrome P4503A4 in Lipid Nanodiscs

Wynton D. McClary et al.

BIOCHEMISTRY (2016)

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Article Biophysics

Formation of size-controlled, denaturation-resistant lipid nanodiscs by an amphiphilic self-polymerizing peptide

Hiroaki Kondo et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Article Chemistry, Multidisciplinary

Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems

Gavin Hazell et al.

LANGMUIR (2016)

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Article Chemistry, Multidisciplinary

Influence of lipid bilayer properties on nanodisc formation mediated by styrene/maleic acid copolymers

Rodrigo Cuevas Arenas et al.

NANOSCALE (2016)

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Article Biochemistry & Molecular Biology

Nanodiscs for structural and functional studies of membrane proteins

Ilia G. Denisov et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Nanodiscs for structural and functional studies of membrane proteins

Ilia G. Denisov et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

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Review Polymer Science

Applications of Solid-State NMR Spectroscopy for the Study of Lipid Membranes with Polyphilic Guest (Macro)Molecules

Ruth Baerenwald et al.

POLYMERS (2016)

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Article Biochemistry & Molecular Biology

Effects of Membrane Mimetics on Cytochrome P450-Cytochrome b5 Interactions Characterized by NMR Spectroscopy

Meng Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Article Multidisciplinary Sciences

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

Mohammad T. Mazhab-Jafari et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Multidisciplinary Sciences

Architecture and conformational switch mechanism of the ryanodine receptor

Rouslan G. Efremov et al.

NATURE (2015)

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Article Chemistry, Multidisciplinary

Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance

Min-Kyu Cho et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Review Biochemistry & Molecular Biology

Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains

Zhengrong Yang et al.

PROTEIN SCIENCE (2014)

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Review Biophysics

Influences of Membrane Mimetic Environments on Membrane Protein Structures

Huan-Xiang Zhou et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 42 (2013)

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Article Biochemistry & Molecular Biology

A Model of the Membrane-bound Cytochrome b5-Cytochrome P450 Complex from NMR and Mutagenesis Data

Shivani Ahuja et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Multidisciplinary Sciences

Antiparallel EmrE exports drugs by exchanging between asymmetric structures

Emma A. Morrison et al.

NATURE (2012)

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Review Biochemistry & Molecular Biology

The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b5

Sang-Choul Im et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)

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Article Biochemistry & Molecular Biology

Nanodiscs versus Macrodiscs for NMR of Membrane Proteins

Sang Ho Park et al.

BIOCHEMISTRY (2011)

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Article Biochemical Research Methods

Crystallizing membrane proteins using lipidic bicelles

Rachna Ujwal et al.

METHODS (2011)

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Article Biochemistry & Molecular Biology

Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450

Djemel Hamdane et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Biochemical Research Methods

Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase

F. Peter Guengerich et al.

NATURE PROTOCOLS (2009)

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Article Biochemistry & Molecular Biology

Effect of Leucine to Phenylalanine Substitution on the Nonpolar Face of a Class A Amphipathic Helical Peptide on Its Interaction with Lipid HIGH RESOLUTION SOLUTION NMR STUDIES OF 4F-DIMYRISTOYLPHOSPHATIDYLCHOLINE DISCOIDAL COMPLEX

Vinod K. Mishra et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Chemistry, Multidisciplinary

Solid-state NMR reveals structural and dynamical properties of a membrane-anchored electron-carrier protein, cytochrome b5

Ulrich H. N. Durr et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

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Article Biochemical Research Methods

Bicelle samples for solid-state NMR of membrane proteins

Anna A. De Angelis et al.

NATURE PROTOCOLS (2007)

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Article Biotechnology & Applied Microbiology

Opinion - How many drug targets are there?

John P. Overington et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

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Article Biochemistry & Molecular Biology

Association of a model class a (apolipoprotein) amphipathic α helical peptide with lipid -: High resolution NMR studies of peptide-lipid discoidal complexes

VK Mishra et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Biochemistry & Molecular Biology

Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: Heterogeneity of the enzyme caused by its oligomerization

DR Davydov et al.

BIOCHEMISTRY (2005)

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Article Chemistry, Physical

Thermotropic phase transition in soluble nanoscale lipid bilayers

IG Denisov et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2005)

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Article Biochemistry & Molecular Biology

The role of the length and sequence of the linker domain of cytochrome b5 in stimulating cytochrome P4502B4 catalysis

TA Clarke et al.

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