The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration

Planarians represent the most primitive bilateral triploblastic animals. Most planarian species exhibit mechanisms for whole-body regeneration, exemplified by the regeneration of their cephalic ganglion after complete excision. Given their robust whole-body regeneration capacity, planarians have been model organisms in regenerative research for more than 240 years. Advancements in research tools and techniques have progressively elucidated the mechanisms underlying planarian regeneration. Accurate cell-cell communication is recognized as a fundamental requirement for regeneration. In recent decades, mechanisms associated with such communication have been revealed at the cellular level. Notably, stem cells (neoblasts) have been identified as the various tissues during homeostasis and regeneration. animal regeneration.

Automated summary

Planarians, the most primitive bilateral triploblastic animals, possess robust whole-body regeneration capacity, making them ideal model organisms for regenerative research. Recent studies have elucidated the cellular mechanisms underlying regeneration, particularly the role of stem cells in tissue homeostasis and regeneration.