Evolutionary scaling and cognitive correlates of primate frontal cortex microstructure

Investigating evolutionary changes in frontal cortex microstructure is crucial to understanding how modifications of neuron and axon distributions contribute to phylogenetic variation in cognition. In the present study, we characterized microstructural components of dorsolateral prefrontal cortex, orbitofrontal cortex, and primary motor cortex from 14 primate species using measurements of neuropil fraction and immunohistochemical markers for fast-spiking inhibitory interneurons, large pyramidal projection neuron subtypes, serotonergic innervation, and dopaminergic innervation. Results revealed that the rate of evolutionary change was similar across these microstructural variables, except for neuropil fraction, which evolves more slowly and displays the strongest correlation with brain size. We also found that neuropil fraction in orbitofrontal cortex layers V-VI was associated with cross-species variation in performance on experimental tasks that measure self-control. These findings provide insight into the evolutionary reorganization of the primate frontal cortex in relation to brain size scaling and its association with cognitive processes.

Automated summary

Investigating evolutionary changes in frontal cortex microstructure is crucial to understanding cognition in different primate species. This study found that the rate of evolutionary change is similar across microstructural variables, except for neuropil fraction, which has a stronger correlation with brain size. The study also revealed that neuropil fraction in specific layers of the orbitofrontal cortex is associated with cross-species variation in self-control.