Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022

Monkeypox virus was imported into Finland during late May-early June 2022. Intrahost viral genome variation in a sample from 1 patient comprised a major variant with 3 lineage B.1.3-specific mutations and a minor variant with ancestral B.1 nucleotides. Results suggest either ongoing APOBEC3 enzyme-mediated evolution or co-infection.

Automated summary

Monkeypox virus was introduced to Finland in late May-early June 2022. Analysis of viral genome in a patient's sample showed a major variant with 3 lineage B.1.3-specific mutations and a minor variant with ancestral B.1 nucleotides. The results suggest ongoing evolution mediated by APOBEC3 enzyme or co-infection.