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Markus Muttenthaler et al.
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Justin M. Torner et al.
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Jinshun Zhu et al.
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Asmita Pal et al.
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Gwen R. Buel et al.
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Avinash Kumar et al.
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Nicole Brenner et al.
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Heleen de Jong et al.
RSC CHEMICAL BIOLOGY (2020)
Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants
Fabian Offensperger et al.
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Advances in covalent kinase inhibitors
Ayah Abdeldayem et al.
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Antonina Hafner et al.
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Jitka Dadova et al.
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Aline D. de Araujo et al.
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TRENDS IN MICROBIOLOGY (2018)
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Denise Martinez-Zapien et al.
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C-H Yuan et al.
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Robert Mah et al.
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Katia Zanier et al.
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Katia Zanier et al.
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F. Xavier Bosch et al.
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Tina Ansari et al.
JOURNAL OF VIROLOGY (2012)
Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses
Elizabeth A. White et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library
Yusuke Yamagishi et al.
CHEMISTRY & BIOLOGY (2011)
Methods for converting cysteine to dehydroalanine on peptides and proteins
Justin M. Chalker et al.
CHEMICAL SCIENCE (2011)
Highly potent and specific siRNAs against E6 or E7 genes of HPV16-or HPV18-infected cervical cancers
J. T-C Chang et al.
CANCER GENE THERAPY (2010)
Human papillomavirus: gene expression, regulation and prospects for novel diagnostic methods and antiviral therapies
Sheila V. Graham
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Human papillomavirus oncoproteins: pathways to transformation
Cary A. Moody et al.
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Sara I. Pai et al.
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A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein
Susanne Dymalla et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2009)
New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer
K. Yamato et al.
CANCER GENE THERAPY (2008)
Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo
XY Niu et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2006)
Design and characterization of helical peptides that inhibit the E6 protein of papillornavirus
YQ Liu et al.
BIOCHEMISTRY (2004)
Domain substructure of HPV E6 oncoprotein:: Biophysical characterization of the E6 C-terminal DNA-binding domain
Y Nominé et al.
BIOCHEMISTRY (2003)
Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants
CF Shuman et al.
ANTIVIRAL RESEARCH (2003)
Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP
XB Be et al.
BIOCHEMISTRY (2001)
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator
L Ko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)