The manuscript describes a highly regioselective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-amino-pyrimidinones under ambient conditions, resulting in the synthesis of functionalized pteridines with excellent yields. The optimized procedures are mild, operationally simple, and effective with different substrates. The synthesis of functionalized pteridines is of great significance due to their potential pharmacological profile.
The manuscript describes the highly regioselective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-amino-pyrimidinones under ambient conditions. The cyclization afforded functionalized pteridines in excellent yields. The optimized procedures are mild, operationally simple and working successfully with different substrates. The synthesis of functionalized pteridines is of great significance because of their potential pharmacological profile.
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