Unveiling the dual role of autophagy in vascular remodelling and its related diseases

Article Peripheral Vascular Disease

The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension

Changlei Bao et al.

Summary: ROC-325 is a promising agent for the treatment of pulmonary hypertension (PH) that inhibits autophagy, downregulates HIF levels, and increases nitric oxide production.

HYPERTENSION (2023)

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Review Genetics & Heredity

Autophagy genes in biology and disease

Hayashi Yamamoto et al.

Summary: Macroautophagy and microautophagy are highly conserved cellular processes in eukaryotes that involve the degradation of cellular material in lysosomes. These processes are regulated by autophagy-related proteins and other molecules, with some shared components between the pathways. Recent advancements in technology have allowed for a better understanding of the functions of individual autophagy gene products and their implications in human disorders. Additionally, genome data has shed light on the evolution of autophagy genes and their origins in prokaryotes.

NATURE REVIEWS GENETICS (2023)

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Review Biochemistry & Molecular Biology

Mitochondrial quality control in abdominal aortic aneurysm: From molecular mechanisms to therapeutic strategies

Ding Wang et al.

Summary: Mitochondria play a crucial role in cellular energy supply and are essential for eukaryotic life. Dysfunctional mitochondria have been implicated in the development of abdominal aortic aneurysm (AAA). Various mechanisms involved in mitochondrial quality control (MQC), such as DNA repair, biogenesis, antioxidant defense, dynamics, and autophagy, are vital for maintaining mitochondrial homeostasis under both normal and pathological conditions. Disruption of these mechanisms can lead to mitochondrial damage and dysfunction, ultimately resulting in cell death and tissue remodeling. Recent evidence suggests that dysregulation of MQC is closely linked to AAA pathogenesis. Therefore, targeting MQC mechanisms to preserve and restore mitochondrial function holds promise as a therapeutic approach for AAA prevention and treatment.

FASEB JOURNAL (2023)

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Review Medicine, Research & Experimental

How ginseng regulates autophagy: Insights from multistep process

Rongchen Dai et al.

Summary: This review comprehensively describes the relationship between ginseng and autophagy, emphasizing its important roles in treating diseases such as cancer, neurological disorders, cardiovascular diseases, inflammation, and neurotoxicity. The review also discusses the interactions between ginseng-regulated autophagy and apoptosis, as well as the cross-signal transduction pathways underlying these processes.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Food Science & Technology

Astaxanthin impact on brain: health potential and market perspective

Sara A. Cunha et al.

Summary: Nowadays, there is a growing interest in new trend-driven biomolecules to improve health and wellbeing. Astaxanthin, obtained from natural sources like microalgae, has shown promising benefits in mental health and illness, primarily due to its high antioxidant and anti-inflammatory properties which may attenuate symptoms of various brain disorders.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Review Cardiac & Cardiovascular Systems

Pathogenesis and management of abdominal aortic aneurysm

Jonathan Golledge et al.

Summary: Abdominal aortic aneurysm (AAA) causes a high number of deaths worldwide every year, but no drug therapy has been proven to effectively limit AAA growth in randomized controlled trials. Genome-wide association studies have identified potential drug targets, and treatments to reduce low-density lipoprotein cholesterol and smoking cessation are also being considered. However, previous placebo-controlled randomized trials have not shown convincing evidence of drug efficacy, mainly due to limitations such as small sample sizes and poor participant retention. Further large prospective studies on other targets are needed to address this issue.

EUROPEAN HEART JOURNAL (2023)

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Article Pharmacology & Pharmacy

Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling

Limin Chai et al.

Summary: This study investigated the molecular mechanisms of macrophage migration inhibitory factor (MIF) in promoting pulmonary artery smooth muscle cells (PASMCs) proliferation, migration, and vascular remodeling in pulmonary hypertension (PH). The results showed that MIF activated the STAT3/ATF6/autophagy cascade and subsequently degraded PDCD4, leading to PASMCs proliferation/migration and pulmonary vascular remodeling. Intervention targeting this axis might be a potential strategy for managing PH.

EUROPEAN JOURNAL OF PHARMACOLOGY (2023)

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Review Biochemistry & Molecular Biology

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Jun Ma et al.

Summary: Hypertension is a complex condition that affects vascular function and is difficult to cure due to its complex mechanisms involving multiple interactive factors. This article comprehensively reviews the signaling pathways involved in vascular function regulation and hypertension progression, including calcium pathway, NO-NOsGC-cGMP pathway, various vascular remodeling pathways, and important upstream pathways. The article also discusses the treatment methods targeting vascular function regulation and the possibility of applying these signaling pathways to clinical work.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Article Biochemistry & Molecular Biology

Ubiquitinated AIF is a major mediator of hypoxia-induced mitochondrial dysfunction and pulmonary artery smooth muscle cell proliferation

Cui Ma et al.

Summary: Our study demonstrates that AIF deficiency in PASMCs leads to impaired oxidative phosphorylation, increased glycolysis, and release of ROS. AIF is downregulated and ubiquitinated under hypoxia, leading to abnormal occurrence of mitophagy and autophagy through its interaction with ubiquitin protein UBA52. Overexpressing AIF using adeno-associated virus vector protects pulmonary vascular remodeling from dysfunctional and abnormal proliferation.

CELL AND BIOSCIENCE (2022)

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Review Cell Biology

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

Anqi Li et al.

Summary: Mitophagy is a crucial cellular process that maintains cellular functions by degrading damaged mitochondria. Abnormal mitophagy is closely related to the pathogenesis of many diseases. Dysfunctional mitochondria accumulation plays a significant role in cardiovascular diseases.

CELL DEATH & DISEASE (2022)

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Article Cell Biology

Ibandronate promotes autophagy by inhibiting Rac1-mTOR signaling pathway in vitro and in vivo

Jie Han et al.

Summary: This study found that IBAN enhances autophagy by inhibiting the Rac1-mTOR signaling pathway and alleviates Ang II-induced injury in endothelial cells under hypertension conditions.

CELL DEATH DISCOVERY (2022)

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Article Cell Biology

Aldehyde Dehydrogenase 2 (ALDH2) Elicits Protection against Pulmonary Hypertension via Inhibition of ERK1/2-Mediated Autophagy

Suchi Chang et al.

Summary: The study demonstrates that ALDH2 deficiency exacerbates right ventricular pressure, hypertrophy, fibrosis, and right heart failure caused by hypoxia-induced pulmonary hypertension, possibly by regulating autophagy through the ERK1/2-Beclin-1 pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Cell Biology

FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia

Ruxia Liu et al.

Summary: This study reveals that mitophagy is actively involved in hypoxic pulmonary hypertension (PH) by regulating pulmonary artery smooth muscle cell (PASMC) proliferation. FUNDC1-mediated mitophagy is upregulated during hypoxic PH and activates the ROS-HIF1α pathway, ultimately leading to pulmonary vascular remodeling and the development of PH.

CELL DEATH & DISEASE (2022)

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Article Respiratory System

Activation of Autophagy Induces Monocrotaline-Induced Pulmonary Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation

Cui Zhai et al.

Summary: This study demonstrates that the activation of autophagy in pulmonary arterial hypertension (PAH) is mediated by FOXM1 and FAK phosphorylation. Inhibition of FOXM1 or FAK suppresses the development of PAH and the proliferation of pulmonary arterial smooth muscle cells.

LUNG (2022)

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Article Reproductive Biology

MiR-141-3p promotes hypoxia-induced autophagy in human placental trophoblast cells

Qiqi Luo et al.

Summary: Preeclampsia is a pregnancy-specific disorder that affects the health of mothers, fetuses, and newborns globally. Autophagy and microRNA-141-3p play important roles in the pathogenesis of preeclampsia.

REPRODUCTIVE BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Vascular Extracellular Matrix Remodeling and Hypertension

Zeyu Cai et al.

Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Article Cardiac & Cardiovascular Systems

Single-cell RNA sequencing reveals cell type- and artery type-specific vascular remodelling in male spontaneously hypertensive rats

Jun Cheng et al.

Summary: This study systematically characterized vascular remodelling in hypertension using SHRs, revealing dysregulated genes specific for artery types and cell types. The expansion of MSCs in MA and increased immune cells in AA were notable findings, pointing to artery type- and cell type-specific changes during hypertensive vascular remodelling.

CARDIOVASCULAR RESEARCH (2021)

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Article Physiology

Defective autophagy in vascular smooth muscle cells enhances the healing of abdominal aortic aneurysm

Akihiro Mochida et al.

Summary: This study investigates the role of smooth muscle cell (SMC) autophagy in the pathogenesis of abdominal aortic aneurysm (AAA), showing that defective autophagy in SMCs can lead to AAA healing and improved survival rates.

PHYSIOLOGICAL REPORTS (2021)

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Review Peripheral Vascular Disease

Mechanisms of Vascular Remodeling in Hypertension

Jay D. Humphrey

Summary: Inflammation-driven adventitial fibrosis plays a key role in central artery remodeling, significantly reducing central artery function, disrupting hemodynamics, compromising end organ perfusion, and ultimately driving associated morbidity and mortality.

AMERICAN JOURNAL OF HYPERTENSION (2021)

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Article Biochemistry & Molecular Biology

Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application

Hai-Peng Li et al.

Summary: The dysfunctions of vascular smooth muscle cells (VSMCs) play crucial roles in vascular remodeling in hypertension, while autophagy is increased in hypertensive individuals. Mechanobiological mechanisms of VSMC autophagy and its potential roles in vascular remodeling remain unclear. Blocking autophagic flux may provide a practical way to alleviate pathological vascular remodeling in hypertension.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Review Cardiac & Cardiovascular Systems

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

Mandy O. J. Grootaert et al.

Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.

CARDIOVASCULAR RESEARCH (2021)

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Article Pharmacology & Pharmacy

Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2/AMPK/TSC2 pathway

Chao Li et al.

Summary: The number and function of EPCs are significantly decreased in hypertensive patients, with decreased autophagy being responsible for senescence and damage. LncRNA-p21 plays a critical role in regulating EPC senescence and dysfunction, and its activation of the SESN2/AMPK/TSC2 pathway enhances autophagy to protect against AngII-induced EPC damage, making it a potential therapeutic target for vascular endothelial repair in hypertension.

PHARMACOLOGICAL RESEARCH (2021)

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Review Cardiac & Cardiovascular Systems

Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms

Haocheng Lu et al.

Summary: Aortic aneurysm, including thoracic and abdominal types, is a prevalent aortic disease and a major cause of death globally. Treatments include open surgery and endovascular procedures. Thoracic aneurysm is more genetically influenced, while both types share common features like loss of VSMCs and inflammation.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

Guideline-Driven Management of Hypertension An Evidence-Based Update

Robert M. Carey et al.

Summary: This review summarizes important findings on prevention, detection, and management of hypertension since 2017, analyzing research published between 2018 and 2021. The studies cover various aspects including blood pressure measurement, risk assessment, treatment targets, with the potential to increase awareness and control of hypertension.

CIRCULATION RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension

Yann Grobs et al.

Summary: Trifluoperazine (TFP), an antipsychotic drug, has shown anti-cancer effects and potential for treating pulmonary arterial hypertension (PAH) by reducing PASMC proliferation, increasing apoptosis, and improving survival rates. This study demonstrates the beneficial effects of TFP in PAH treatment through in vitro and in vivo experiments, supporting the idea that repurposing old drugs could be a fruitful approach in medical research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

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Article Oncology

Apelin receptor upregulation in spontaneously hypertensive rat contributes to the enhanced vascular smooth muscle cell proliferation by activating autophagy

Tao Xu et al.

Summary: In hypertensive rats, there is an increase in APJ expression and a decrease in apelin expression, while apelin-13 stimulates VSMC proliferation through APJ-mediated enhancement of autophagy. The effects of apelin-13 on VSMC proliferation can be blocked by the APJ antagonist F13A. Additionally, the autophagy inhibitor 3-MA can attenuate VSMC proliferation.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Review Urology & Nephrology

Hypertension-induced cognitive impairment: from pathophysiology to public health

Zoltan Ungvari et al.

Summary: Hypertension has significant impacts on cerebral microcirculation which can lead to cognitive impairment, especially in the elderly. Interventions targeting blood pressure reduction, lifestyle changes, and promoting microvascular health have the potential to prevent or delay vascular cognitive impairment and Alzheimer's disease in hypertensive patients.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Physiology

Metformin Inhibits Abdominal Aortic Aneurysm Formation through the Activation of the AMPK/mTOR Signaling Pathway

Jiaan He et al.

Summary: This study demonstrated that MET inhibits AAA formation by activating the AMPK/mTOR signaling pathway, resulting in decreased aortic diameter, inhibition of macrophage infiltration and matrix metalloproteinase expression, reduced neovascularization, preservation of the contractile phenotype of aortic vascular smooth muscle cells, and promotion of autophagy.

JOURNAL OF VASCULAR RESEARCH (2021)

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Review Cell Biology

Endovascular trophoblast and spiral artery remodeling

Yukiyasu Sato

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)

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Article Cell Biology

A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy

Qi-ying Wu et al.

CELL DEATH & DISEASE (2020)

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Article Cardiac & Cardiovascular Systems

Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms

Shuai Liu et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Cell Biology

Astaxanthin Attenuates Hypertensive Vascular Remodeling by Protecting Vascular Smooth Muscle Cells from Oxidative Stress-Induced Mitochondrial Dysfunction

Yuqiong Chen et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Physiology

Melatonin Plays a Critical Protective Role in Nicotine-Related Abdominal Aortic Aneurysm

Liren Duan et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Medicine, General & Internal

The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy

Huanqiang Zhao et al.

EBIOMEDICINE (2020)

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Review Physiology

Cellular Pathways Promoting Pulmonary Vascular Remodeling by Hypoxia

Larissa A. Shimoda

PHYSIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm

Rijan Gurung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, Research & Experimental

TMEM16A ameliorates vascular remodeling by suppressing autophagy via inhibiting Bcl-2-p62 complex formation

Xiao-Fei Lv et al.

THERANOSTICS (2020)

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Article Cardiac & Cardiovascular Systems

Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling

Jian Guo et al.

CIRCULATION RESEARCH (2019)

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Article Cardiac & Cardiovascular Systems

Preeclampsia Pathophysiology, Challenges, and Perspectives

Sarosh Rana et al.

CIRCULATION RESEARCH (2019)

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Editorial Material Medicine, Research & Experimental

The pathophysiological basis of vascular disease

Alicia N. Lyle et al.

LABORATORY INVESTIGATION (2019)

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Article Engineering, Biomedical

The role of tissue remodeling in mechanics and pathogenesis of abdominal aortic aneurysms

Justyna A. Niestrawska et al.

ACTA BIOMATERIALIA (2019)

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Article Pharmacology & Pharmacy

Dacomitinib, a new pan-EGFR inhibitor, is effective in attenuating pulmonary vascular remodeling and pulmonary hypertension

Xiufeng Yu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Review Cell Biology

Autophagy in pulmonary hypertension: Emerging roles and therapeutic implications

Chun-Fang Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Hematology

Smooth Muscle Cell Phenotypic Diversity At the Crossroads of Lineage Tracing and Single-Cell Transcriptomics

Mingjun Liu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes

Armand Jaminon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE-/- mice

Danyang Li et al.

FASEB JOURNAL (2019)

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Article Surgery

Loss of vascular smooth muscle cell autophagy exacerbates angiotensin II-associated aortic remodeling

Azza Ramadan et al.

JOURNAL OF VASCULAR SURGERY (2018)

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Review Biochemistry & Molecular Biology

Dual role of autophagy in hallmarks of cancer

Shikha Satendra Singh et al.

ONCOGENE (2018)

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Article Cell Biology

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

Yusuke Osonoi et al.

AUTOPHAGY (2018)

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Review Cardiac & Cardiovascular Systems

Smooth muscle cell fate and plasticity in atherosclerosis

Sima Allahverdian et al.

CARDIOVASCULAR RESEARCH (2018)

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Review Cardiac & Cardiovascular Systems

Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis

Mandy O. J. Grootaert et al.

CARDIOVASCULAR RESEARCH (2018)

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Review Cardiac & Cardiovascular Systems

Vascular smooth muscle contraction in hypertension

Rhian M. Touyz et al.

CARDIOVASCULAR RESEARCH (2018)

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Review Cell Biology

Mechanism and medical implications of mammalian autophagy

Ivan Dikic et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Review Multidisciplinary Sciences

Spermidine in health and disease

Frank Madeo et al.

SCIENCE (2018)

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Article Pathology

Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension

Aiko Aoki et al.

AMERICAN JOURNAL OF PATHOLOGY (2018)

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Review Biochemistry & Molecular Biology

The role of autophagy in pulmonary hypertension: a double-edge sword

Rui Chen et al.

APOPTOSIS (2018)

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Article Hematology

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

Isola A. M. Brown et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

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Article Cell Biology

Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene

Peng Zhang et al.

CELL DEATH & DISEASE (2018)

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Article Pharmacology & Pharmacy

Docetaxel Reverses Pulmonary Vascular Remodeling by Decreasing Autophagy and Resolves Right Ventricular Fibrosis

Yasmine F. Ibrahim et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

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Review Biochemistry & Molecular Biology

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension

A. A. Roger Thompson et al.

TRENDS IN MOLECULAR MEDICINE (2017)

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Article Physiology

Endothelial cell-related autophagic pathways in Sugen/hypoxia-exposed pulmonary arterial hypertensive rats

Fumiaki Kato et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Vascular Smooth Muscle Cells in Atherosclerosis

Martin R. Bennett et al.

CIRCULATION RESEARCH (2016)

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Article Cell Biology

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

Mandy O. J. Grootaert et al.

AUTOPHAGY (2015)

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Article Medicine, Research & Experimental

Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway

Lingxia Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)

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Article Surgery

Rapamycin Limits the Growth of Established Experimental Abdominal Aortic Aneurysms

M. Rouer et al.

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY (2014)

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Review Immunology

A review of the mechanism for poor placentation in early-onset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling

Shigeru Saito et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2014)

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Article Cardiac & Cardiovascular Systems

Impact of Positive and Negative Lesion Site Remodeling on Clinical Outcomes

Shinji Inaba et al.

JACC-CARDIOVASCULAR IMAGING (2014)

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Article Chemistry, Multidisciplinary

Why should autophagic flux be assessed?

Xiao-jie Zhang et al.

ACTA PHARMACOLOGICA SINICA (2013)

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Article Biochemistry & Molecular Biology

Adenosine Monophosphate-Activated Protein Kinase Is Required for Pulmonary Artery Smooth Muscle Cell Survival and the Development of Hypoxic Pulmonary Hypertension

Joyce Christina F. Ibe et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

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Article Cell Biology

Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia

Akitoshi Nakashima et al.

AUTOPHAGY (2013)

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Article Biochemistry & Molecular Biology

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

Joshua K. Salabei et al.

BIOCHEMICAL JOURNAL (2013)

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Article Cardiac & Cardiovascular Systems

Chloroquine Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Lysosomal Bone Morphogenetic Protein Type II Receptor Degradation

Lu Long et al.

CIRCULATION RESEARCH (2013)

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Article Endocrinology & Metabolism

Hypoxia Induces Autophagy in Primary Human Trophoblasts

Baosheng Chen et al.

ENDOCRINOLOGY (2012)

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Article Cell Biology

Osteopontin Stimulates Autophagy Via Integrin/CD44 and p38 MAPK Signaling Pathways in Vascular Smooth Muscle Cells

Yue-Hong Zheng et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

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Article Critical Care Medicine

Autophagic Protein LC3B Confers Resistance against Hypoxia-Induced Pulmonary Hypertension

Seon-Jin Lee et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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Review Immunology

The immune system in atherosclerosis

Goran K. Hansson et al.

NATURE IMMUNOLOGY (2011)

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Review Urology & Nephrology

Role of extracellular matrix in vascular remodeling of hypertension

Ana M. Briones et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2010)

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Review Peripheral Vascular Disease

Learning From the Placenta Acute Atherosis and Vascular Remodeling in Preeclampsia-Novel Aspects for Atherosclerosis and Future Cardiovascular Health

Anne Cathrine Staff et al.

HYPERTENSION (2010)

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Article Surgery

Gene Expression Profiling of Peripheral Blood in Patients with Abdominal Aortic Aneurysm

B. Giusti et al.

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY (2009)

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Review Medicine, General & Internal

Essential hypertension

Franz H. Messerli et al.

LANCET (2007)

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Review Cardiac & Cardiovascular Systems

Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling - Molecular, cellular, and vascular behavior

Yiannis S. Chatzizisis et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)

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Article Surgery

Rapamycin suppresses experimental aortic aneurysm growth

DM Lawrence et al.

JOURNAL OF VASCULAR SURGERY (2004)

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Article Cardiac & Cardiovascular Systems

Relationship between coronary artery remodeling and plaque vulnerability

AM Varnava et al.

CIRCULATION (2002)

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Article Peripheral Vascular Disease

Vascular remodeling in hypertension - Roles of apoptosis, inflammation, and fibrosis

HD Intengan et al.

HYPERTENSION (2001)

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Unveiling the dual role of autophagy in vascular remodelling and its related diseases

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