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Review
Cell Biology
Archittapon Nokkeaw et al.
Summary: Chronic liver injury leads to HSC activation and production of excessive ECM, resulting in tissue fibrosis. Understanding the molecular mechanisms that control HSC activation could lead to the development of new anti-fibrotic therapies. Recent studies have identified circRNAs as new regulators in HSC activation, which can modulate miRNA activity involved in fibrogenic signaling cascades.
Review
Cardiac & Cardiovascular Systems
Timothy A. McKinsey et al.
Summary: Cardiovascular diseases and heart failure have a significant impact on global health and impose a large economic burden. Despite advances in standard care, the risks for death and readmission of heart failure patients are still unacceptably high, necessitating the development of new therapeutic strategies. This review summarizes current knowledge on novel cellular and epigenetic therapies, with a focus on non-coding RNA-based strategies in early clinical development to counteract cardiac remodeling and heart failure. The review also discusses the current status, limitations, and future perspectives of translating these novel therapies into clinical practice.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cell Biology
Yan Chen et al.
Summary: This study reveals that long noncoding RNA NEAT1 plays a crucial role in renal fibrosis. NEAT1 accelerates fibrosis progression by negatively regulating miR-31 and activating the RhoA/ROCK1 pathway, leading to the upregulation of connective tissue growth factor (CTGF) expression.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Physiology
Rebecca J. Calthorpe et al.
Summary: As survival rates for extremely preterm infants improve, there is an increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial, resulting from exposure to various antenatal and postnatal stressors. BPD has short-term and long-term implications, including respiratory, cardiovascular, and neurological issues. The review focuses on the role of transforming growth factor I3 (TGF-I3) in lung development, the impact of known risk factors on the TGF-I3 signaling pathway in BPD, and the effect of current and potential medications on TGF-I3 signaling for BPD prevention and treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuqing Lu et al.
Summary: The study investigated the influence of tubular epithelial cells (TECs) undergoing epithelial-to-mesenchymal transition (EMT) on the phenotypes of macrophages. Exosomes released by TECs undergoing EMT induced M1 polarization in macrophages, promoting further EMT and the development of renal fibrosis. Inhibiting the release of such exosomes may be a potential therapeutic strategy for chronic kidney disease (CKD).
Review
Oncology
Erik Knutsen et al.
Summary: NEAT1 is a highly abundant nuclear architectural long non-coding RNA, playing important roles in cellular stress and developmental processes. Abnormal expression of NEAT1 in many cancers may be associated with therapy resistance and poor clinical outcome.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Zhuowang Ge et al.
Summary: This study reveals the role and mechanism of the lncRNA NEAT1 in the progression of cardiac fibrosis to heart failure. NEAT1 is upregulated in heart failure patients and its overexpression accelerates fibrosis, while silencing NEAT1 attenuates fibrosis. The mechanism involves NEAT1 recruiting EZH2 to suppress the expression of Smad7.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Cell Biology
Amela Jusic et al.
Summary: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, posing a significant economic burden and public health concern. Noncoding transcripts, specifically noncoding RNAs, play vital roles in aging and contribute to the development of cardiovascular diseases. They regulate biological processes related to aging and impact pathophysiological developments within the cardiovascular system.
AGEING RESEARCH REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Tongtong Ma et al.
Summary: In this study, it was discovered through high-throughput RNA sequencing that Neat1_2, a transcript variant of Neat1, was upregulated in acute kidney injury (AKI) and played a role in promoting apoptosis of injured tubular epithelial cells, resulting in tubulointerstitial inflammation and fibrosis. This effect was mediated by the competitive binding of Neat1_2 to miR-129-5p, which prevented miR-129-5p from decreasing the levels of FADD, CASP-8, and CASP-3.
Article
Cell Biology
Bo Shu et al.
Summary: This study reveals the important role of exosomal NEAT1 derived from macrophages in the progression of hepatic fibrosis (HF). Exosomal NEAT1 promotes the proliferation and migration of hepatic stellate cells (HSCs), and induces the expression of fibrotic proteins. Furthermore, exosomal NEAT1 contributes to HSCs activation by sponging miR-342, leading to the development of HF. These findings provide new potential targets for the treatment of HF.
CELL DEATH DISCOVERY
(2022)
Review
Oncology
Shirin Azizidoost et al.
Summary: Colorectal cancer is the third leading cause of cancer death in the world. Recent studies have shown that long non-coding RNAs play important roles in colorectal cancer cells, and NEAT1 is a key factor involved in the development and progression of colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Zhang Xiang et al.
Summary: Long non-coding RNA Gas5 may play a vital regulatory role in organ fibrosis and could serve as a diagnostic biomarker for fibrosis diseases. Structurally, Gas5 impacts fibrosis through distinct structural modules, influencing cell proliferation, survival, inflammatory processes, and extracellular matrix deposition.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Immunology
Bahareh Karimi et al.
Summary: Long non-coding RNAs (lncRNAs) are RNA molecules that do not encode proteins and have important regulatory functions. Irregular expression of lncRNAs has been associated with various diseases and they are considered potential diagnostic biomarkers. Circulating lncRNAs, including exosomal lncRNAs, are stable in body fluids and have resistance against RNases. Exosomes, which regulate communication between cells, play critical roles in the pathological processes of autoimmune diseases. Circulating lncRNAs, particularly exosomal lncRNAs, have been shown to modulate the immune response and serve as prognosis and diagnostic biomarkers for autoimmune diseases.
Article
Medicine, Research & Experimental
Xi Zhang et al.
Summary: The present study investigated the function and mechanism of NEAT1 in the progression of pulmonary fibrosis (PF). The results demonstrated that NEAT1 exerted anti-inflammatory, anti-apoptotic, and anti-fibrotic effects by targeting the miR-29a/NFATc3 axis, suggesting its potential as a therapeutic target for relieving PF progression.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Neurosciences
M. Abrishamdar et al.
Summary: This narrative review discusses the association between the long non-coding RNA (lncRNA) MALAT1 and the pathogenesis of Parkinson's disease (PD), including perturbed alpha-synuclein homeostasis, apoptosis and autophagy, and neuro-inflammation. The importance of MALAT1 as a diagnostic biomarker and its potential in developing therapeutic strategies are highlighted.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Genetics & Heredity
Rosario Castro-Oropeza et al.
Summary: Human Papillomavirus (HPV) is the most common oncogenic virus causing viral-associated cancers worldwide. Non-coding RNAs, including lncRNAs, miRNAs, and circRNAs, are dysregulated in HPV-related neoplasms and play a role in tumor progression and metastasis. Nuclear lncRNAs function as epigenetic regulators and control gene expression at the transcriptional level. Understanding the epigenetic alterations induced by HPV and the role of non-coding RNAs can provide insights into the development and treatment of HPV-associated cancers.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Elena Ortiz-Zapater et al.
Summary: Fibrosis in the lungs is a growing clinical problem that leads to shortness of breath and respiratory failure. It can be caused by various diseases such as idiopathic pulmonary fibrosis, asthma, COPD, allergies, and infection clearance. This review discusses the different types of fibrosis, the main cells involved, and the mechanisms of fibrosis. It also highlights current treatments and potential targets for anti-fibrotic therapies.
Review
Oncology
Jingtao Gu et al.
Summary: NEAT1, especially its isoform NEAT1-1, plays a pivotal role in the progression of cancers by facilitating the growth and metastasis of various cancers, excluding acute promyelocytic leukemia. It can be elevated via transcriptional activation or stability alteration in cancers, and be delivered to cancer cells through exosomes, changing the aggressive phenotype of cancer cells. Elucidating the molecular interaction of NEAT1 may shed light on the future treatment of cancer.
Review
Oncology
Nadine E. Smith et al.
Summary: The long noncoding RNA NEAT1 is often dysregulated in cancer, and it plays a role in promoting glycolysis and cancer cell proliferation. Previous studies have mainly focused on quantifying total NEAT1 and NEAT1_2 expression levels, and the contribution of specific NEAT1 isoforms is not well understood.
Review
Biochemistry & Molecular Biology
Kamila Raziyeva et al.
Summary: Cardiac fibrosis is a common pathological consequence of myocardial diseases, resulting in heart dysfunction and failure. The mechanisms of cardiac fibrosis are still not fully understood, but there have been advances in developing new treatment strategies using cellular and animal models.
Article
Cell Biology
Qi Wang et al.
Summary: The study highlighted the regulatory role of lncRNA NEAT1 and miR-139-5p in liver fibrosis progression, with NEAT1 promoting HSCs activation by sponging miR-139-5p. The overexpression of miR-139-5p or knockdown of NEAT1 alleviated liver fibrosis in vivo by targeting the beta-catenin/SOX9/TGF-beta 1 pathway.
CELL DEATH DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard et al.
Summary: Fibrosis is the endpoint of pathological remodeling, with TGF-β, WNT, and YAP/TAZ signaling pathways playing key roles in this process. Long noncoding RNAs and microRNAs participate in organ fibrosis by modulating the activity of related signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Yuan Liu et al.
Summary: This study demonstrated that NEAT1 acts as a sponge for miR-455-3p, while SMAD3 is a target gene of miR-455-3p. Silencing NEAT1 or mimicking miR-455-3p inhibited the migratory ability, EMT, and collagen production of epithelial cells, but these effects were reversed by the overexpression of SMAD3. NEAT1 knockdown reduced SMAD3 expression by increasing miR-455-3p expression, further inhibiting the migratory ability, EMT, and collagen production of epithelial cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Wei Huang et al.
Summary: In this study, the regulatory effects of lncRNA Neat1 on liver fibrosis and HSC activation were investigated. Neat1 was found to modulate Cyth3 expression by regulating miR-148a-3p and miR-22-3p, affecting liver fibrosis and HSC activation. These findings provide a deeper understanding of the pathogenesis of liver fibrosis and offer insights into the development of lncRNA-directed therapy.
Article
Cell Biology
Rebeca de Oliveira Camargo et al.
Summary: Heart disease with cardiac fibrosis is a leading cause of death in developed countries, surpassing cancer. Recent literature focuses on activating and deactivating mechanisms of cardiac fibroblasts. Activated fibroblasts contribute to acute wound healing and chronic fibrosis, while deactivation is less studied but shows potential therapeutic implications.
WOUND REPAIR AND REGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Yan-Lin Yang et al.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Article
Immunology
Kiyoharu Fukushima et al.
Review
Medicine, General & Internal
Kiyoharu Fukushima et al.
Review
Cell Biology
Xiaoying Jiang et al.
MECHANISMS OF AGEING AND DEVELOPMENT
(2020)
Article
Biochemistry & Molecular Biology
Stefania Di Mauro et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Junfeng Ye et al.
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Physiology
Chen Li et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Franziska Kenneweg et al.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Medicine, Research & Experimental
Yangyang Kong et al.
Article
Cell Biology
Shan Huang et al.
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Si-Si Jin et al.
EUROPEAN CYTOKINE NETWORK
(2019)
Article
Genetics & Heredity
Fujun Yu et al.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2017)
Article
Multidisciplinary Sciences
Varun Kesherwani et al.
