4.6 Article

Investigation on repairing diabetic foot ulcer based on 3D bio-printing Gel/ dECM/Qcs composite scaffolds

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Construction of Smart Biomaterials for Promoting Diabetic Wound Healing

Chan Huang et al.

Summary: Diabetes mellitus has become one of the fastest-growing health crises due to its various complications, including diabetic foot, which can seriously affect patients' life and health. Smart biomaterials have been developed to improve the healing process and outcomes of diabetic wound treatment by acting as a drug delivery system and responsive to the wound microenvironment.

MOLECULES (2023)

Article Engineering, Biomedical

A 3D bioprinted tumor model fabricated with gelatin/sodium alginate/decellularized extracellular matrix bioink

Jie Xu et al.

Summary: Compared to conventional two-dimensional cell culture, tissue-engineered scaffolds are more commonly used to construct three-dimensional tumor models for in vitro studies because they can provide microenvironments that closely resemble the in vivo system and have a higher success rate when translated to pre-clinical animal models. In this study, a novel 3D breast tumor model was fabricated using a bioink made of porcine liver-derived decellularized extracellular matrix (dECM), gelatin, and sodium alginate. The physical properties of the hybrid scaffolds were investigated and found to be influenced by the concentrations of gelatin and sodium alginate. The 3D breast tumor model showed good biocompatibility and could be used as an effective platform for anticancer drug screening and cancer research in vitro.

INTERNATIONAL JOURNAL OF BIOPRINTING (2023)

Article Instruments & Instrumentation

Mesenchymal stem cells' seeded amniotic membrane as a tissue-engineered dressing for wound healing

Hamid Reza Aghayan et al.

Summary: This study investigated the regenerative effects of tissue-engineered dressings composed of human amniotic membrane graft (AM) and two types of mesenchymal stem cells (MSCs) in a rat excisional wound model. The results demonstrated that MSC-seeded AMs had superior effects on wound closure rate, re-epithelialization, angiogenesis, and collagen remodeling compared to the control groups, with placenta-derived MSCs (PLMSCs) showing better healing effects. Seeding of MSCs on AM boosted its regenerative effects in wound treatment, with PLMSCs having superior effects to ADMSCs in the excisional wound rat model.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Review Pharmacology & Pharmacy

Antibacterial biomaterials for skin wound dressing

Yuqing Liang et al.

Summary: Bacterial infection and resistance pose a significant threat to human health, especially in wound healing. This review focuses on antibacterial wound dressings and discusses various biomaterials and antibacterial agents used in their fabrication. It also explores challenges and future perspectives in this field.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Review Oncology

Anti-inflammatory hydrogel dressings and skin wound healing

Can Huang et al.

Summary: Hydrogel dressings have shown promising potential in the biomedical field, particularly in promoting wound healing. In recent years, significant progress has been made in addressing excessive inflammation and promoting wound healing with hydrogel dressings. Excessive inflammation is a common issue in chronic wounds, hindering the repair process. Therefore, resolving excessive inflammation is crucial for effective wound healing.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

Article Multidisciplinary Sciences

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

Benu George et al.

Summary: This study demonstrates the potential clinical application of a bioinspired hydrogel in promoting efficient healing of second-degree burn wounds in rat models.

SCIENTIFIC REPORTS (2022)

Article Cell & Tissue Engineering

Human adipose-derived mesenchymal stem cells-derived exosomes encapsulated in pluronic F127 hydrogel promote wound healing and regeneration

Yang Zhou et al.

Summary: This study explores the potential clinical application of hADSCs-Exos encapsulated in PF-127 hydrogel for wound healing. The results showed that PF-127/hADSCs-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased collagen synthesis and expression of skin barrier proteins, and reduced inflammation. Using PF-127/hADSCs-Exos complexes allows for lower doses and frequency of exosome administration while maintaining therapeutic effects.

STEM CELL RESEARCH & THERAPY (2022)

Review Cell & Tissue Engineering

Bone marrow mesenchymal stromal cells for diabetes therapy: touch, fuse, and fix?

Zahra Azizi et al.

Summary: Bone marrow mesenchymal stromal cells have anti-inflammatory and pro-survival properties, and their fusion with transplanted islets can improve diabetes treatment.

STEM CELL RESEARCH & THERAPY (2022)

Article Multidisciplinary Sciences

ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus-infected chronic skin wound healing

Wenshuai Liu et al.

Summary: A glycopeptide hybrid hydrogel with antibacterial and tissue environment-responsive properties was developed for chronic wound healing. The hydrogel can promote cell proliferation and macrophage polarization, and has potent antibacterial effects. It accelerated the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic and scalding skin by promoting M2-type macrophages, reducing inflammation, and promoting angiogenesis.

SCIENCE ADVANCES (2022)

Article Engineering, Biomedical

Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

Mika Brown et al.

Summary: Extracellular matrix is a promising biomaterial candidate for regenerative medicine applications due to its rich biomolecules. Decellularized extracellular matrix (dECM) has been developed in various forms, such as injectable hydrogels, electrospun scaffolds, and bioprinted scaffolds, to engineer different tissue types. This review paper highlights the challenges, fabrication methods, and progress made for each tissue type, aiming to push dECM biomaterials towards effective and specialized tissue repair.

BIOMATERIALS (2022)

Article Chemistry, Applied

A multifunctional chitosan hydrogel dressing for liver hemostasis and infected wound healing

Erkang Yang et al.

Summary: A multifunctional hydrogel dressing QCSMA/DAMA/Zn-nWH was developed for the treatment of infected bleeding wounds. It showed good adhesion, antibacterial properties, and biocompatibility, as well as promoting wound healing and hemostasis.

CARBOHYDRATE POLYMERS (2022)

Article Biochemistry & Molecular Biology

A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering

Jie Xu et al.

Summary: Finding a bioink suitable for 3D bioprinting that can mimic the microenvironment of native skin and prevent bacterial infection remains a major challenge in skin tissue engineering. In this study, a tissue-specific extracellular matrix-based bioink was prepared, and a novel scaffold was obtained using an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The hybrid scaffold exhibited excellent properties including antibacterial activity, hemostatic effect, and biocompatibility.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Review Cell Biology

Exosomes from adipose-derived stem cells and application to skin wound healing

Yang An et al.

Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.

CELL PROLIFERATION (2021)

Article Biotechnology & Applied Microbiology

Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis

Shenglong Li et al.

Summary: The study revealed that extracellular vesicles-chitosan oligosaccharide conjugates could reverse the damage induced by IL-1 beta in chondrocytes, facilitating cartilage injury repair through modulation of multiple signaling pathways.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Endocrinology & Metabolism

Hyperbaric oxygen therapy for chronic diabetic foot ulcers: An overview of systematic reviews

Li Wenhui et al.

Summary: This study evaluated the clinical evidence of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers, and found certain potential to promote ulcer healing and reduce amputation rate, but recommended against routine application of hyperbaric oxygen therapy in all patients with diabetic foot ulcers.

DIABETES RESEARCH AND CLINICAL PRACTICE (2021)

Article Biochemistry & Molecular Biology

Differential Therapeutic Effect of Extracellular Vesicles Derived by Bone Marrow and Adipose Mesenchymal Stem Cells on Wound Healing of Diabetic Ulcers and Correlation to Their Cargoes

Margherita Pomatto et al.

Summary: Research demonstrates that EVs derived from adipose tissue have a positive impact on diabetic wound healing, while those from bone marrow primarily promote cell proliferation. Significant differences exist in the molecular cargo of these two types of EVs, with ADSC-EVs showing greater angiogenic effects, and BMSC-EVs being more inclined towards cellular proliferation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell & Tissue Engineering

Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing

Shune Xiao et al.

Summary: The study demonstrated that hAAM scaffolds incorporated with ADSC-Exos can promote diabetic skin wound healing by regulating inflammation, stimulating vascularization, and promoting the production of extracellular matrix.

STEM CELL RESEARCH & THERAPY (2021)

Review Cell Biology

Chronic Diabetic Wounds and Their Treatment with Skin Substitutes

Jordan Holl et al.

Summary: With the increasing prevalence of type 2 diabetes mellitus, the management of chronic diabetic wounds and ulcers has become a significant therapeutic challenge. Recent advancements in understanding wound healing mechanisms have led to the development of novel therapies, with a particular focus on biological dressings.
Review Polymer Science

Biomedical Applications of Quaternized Chitosan

Kamla Pathak et al.

Summary: Chitosan, a natural polymer, is extensively used for versatile drug delivery systems, with quaternized chitosan being preferred in pharmaceutical industries due to its superior properties. Quaternized chitosan has been widely applied in tissue engineering, wound healing, gene, and vaccine delivery.

POLYMERS (2021)

Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine

Mangesh D. Hade et al.

Summary: Exosomes are extracellular vesicles secreted by almost all cell types to aid in various cellular functions, including intercellular communication and immune signaling. They carry a multitude of signaling moieties, making them potential candidates for tissue engineering and regenerative medicine. The review highlights the emerging roles and potential applications of exosomes in regenerative medicine, particularly in brain injuries, cardiovascular disease, and COVID-19.
Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Review Pharmacology & Pharmacy

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

Erika Maria Tottoli et al.

PHARMACEUTICS (2020)

Review Biochemistry & Molecular Biology

Preparation of Defined Chitosan Oligosaccharides Using Chitin Deacetylases

Martin Bonin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Materials Science, Biomaterials

Hydrogel membranes: A review

Mohsen Khodadadi Yazdi et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Chemistry, Multidisciplinary

Exosomes for Wound Healing: Purification Optimization and Identification of Bioactive Components

Britta F. Hettich et al.

ADVANCED SCIENCE (2020)

Review Cell & Tissue Engineering

Roles for miRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells

Jicheng Wang et al.

STEM CELL RESEARCH & THERAPY (2019)

Article Materials Science, Biomaterials

Enhanced decellularization technique of porcine dermal ECM for tissue engineering applications

Reiza D. Ventura et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N. H. Cho et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Review Biotechnology & Applied Microbiology

Chitosan's biological activity upon skin-related microorganisms and its potential textile applications

Eduardo M. Costa et al.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2018)

Review Chemistry, Multidisciplinary

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

Nikos K. Kararnanos et al.

CHEMICAL REVIEWS (2018)

Review Cell & Tissue Engineering

Role of Mesenchymal Stem Cells in Dermal Repair in Burns and Diabetic Wounds

Eric L. Maranda et al.

CURRENT STEM CELL RESEARCH & THERAPY (2017)

Review Pharmacology & Pharmacy

Chitosan as a starting material for wound healing applications

V. Patrulea et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Article Biochemistry & Molecular Biology

Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics

Honglue Tan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Chemistry, Multidisciplinary

Naturally derived materials-based cell and drug delivery systems in skin regeneration

Sha Huang et al.

JOURNAL OF CONTROLLED RELEASE (2010)

Article Engineering, Biomedical

First steps towards tissue engineering of small-diameter blood vessels: Preparation of flat scaffolds of collagen and elastin by means of freeze drying

L Buttafoco et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2006)

Article Cardiac & Cardiovascular Systems

Early failure of the tissue engineered porcine heart valve SYNERGRAFT™ in pediatric patients

P Simon et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2003)

Review Endocrinology & Metabolism

Diabetic foot ulcers: a quality of tife issue

L Vileikyte

DIABETES-METABOLISM RESEARCH AND REVIEWS (2001)