Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells

Article Reproductive Biology

Single-cell analysis of prostaglandin E2-induced human decidual cell in vitro differentiation: a minimal ancestral deciduogenic signal

Daniel J. Stadtmauer et al.

Summary: The use of PGE(2) and progestin for in vitro decidualization of human endometrial stromal fibroblasts induces a distinct decidual cell state through PTGER(2)-dependent PKA activation, different from the conventional cAMP/MPA protocol.

BIOLOGY OF REPRODUCTION (2022)

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Article Obstetrics & Gynecology

E2+norethisterone promotes the PI3K-AKT pathway via PGRMC1 to induce breast cancer cell proliferation

L. Zhang et al.

Summary: This study found evidence that PGRMC1 promotes E2 + NET-induced breast cancer proliferation through activation of the PI3K-AKT pathway. The mechanism involves cell cycle regulation and upregulation of the PI3K-AKT pathway.

CLIMACTERIC (2022)

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Article Biochemistry & Molecular Biology

PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells

Atsuya Tsuru et al.

Summary: PGRMC1 is involved in cellular senescence during decidualization through the regulation of FOXO1 expression.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis

Charlotte Thieffry et al.

Summary: The expression of PGRMC1 in the uterine endometrium varies throughout the menstrual cycle, increasing during the proliferation phase and decreasing during the secretory phase. However, the localization and distribution of PGRMC1 expression varies within the tissue samples. There is no significant difference in PGRMC1 mRNA levels between patients with or without endometriosis for any phase of the menstrual cycle.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis

Charlotte Thieffry et al.

Summary: The expression of PGRMC1 in human endometrium varies during different phases of the menstrual cycle. While PGRMC1 expression increases during the proliferative phase, it decreases during the secretory phase. Patients with endometriosis show reduced PGRMC1 immunolabeling during the proliferative phase, but there is no significant difference in PGRMC1 mRNA amounts between patients with endometriosis or adenomyosis at any phase of the menstrual cycle. Further research is needed to understand the hormonal control and regulation mechanisms responsible for the fluctuation of PGRMC1 expression in the endometrium.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

The Role of the FOXO1/β2-AR/p-NF-κB p65 Pathway in the Development of Endometrial Stromal Cells in Pregnant Mice under Restraint Stress

Jiayin Lu et al.

Summary: Restraint stress during pregnancy leads to increased levels of corticosterone, norepinephrine, and blood glucose, while decreasing estrogen levels. This stress also activates the beta(2)-AR/FOXO1/p-NF-kappa B pathway, resulting in increased oxidative stress in the maternal uterus. This study sheds light on the impact of psychological stress on pregnant women and their reproductive health.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Endocrinology & Metabolism

Deciphering the Role of PGRMC1 During Human Decidualization Using an In Vitro Approach

Stefania Salsano et al.

Summary: This study found that PGRMC1 inhibition during decidualization in endometrial stromal cells does not interfere with cytoskeletal rearrangements and prolactin secretion, but does affect the expression of genes related to metabolism, transport, and hormonal biosynthesis. Additionally, activation of membrane progesterone receptor signaling alone is insufficient to induce proper decidualization.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Developmental Biology

A positive COX-2/IL-1β loop promotes decidualization by upregulating CD82

Qiu-Chan Qu et al.

Summary: CD82 plays a crucial role in decidualization, promoting the process through a positive feedback loop involving COX-2/PGE2/IL-1β.

REPRODUCTION (2021)

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Article Immunology

Upregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFRI/MitoROS/ PKCα/P38 MAPK, JNKI/2/FoxO1 Cascade in Human Cardiac Fibroblasts

Chuen-Mao Yang et al.

Summary: The study found that TNF-α induces upregulation of COX-2 and PGE(2) through a TNFR1-dependent MitoROS/PKCα/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs. This sheds new light on the mechanisms of TNF-α in cardiac fibrosis and heart failure.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Endocrinology & Metabolism

Inhibition of TPPP3 attenuates β-catenin/NF-κB/COX-2 signaling in endometrial stromal cells and impairs decidualization

Vinay Shukla et al.

JOURNAL OF ENDOCRINOLOGY (2019)

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Article Oncology

Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling

Dan Wang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Multidisciplinary Sciences

VEGF may contribute to macrophage recruitment and M2 polarization in the decidua

Karen C. Wheeler et al.

PLOS ONE (2018)

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Article Obstetrics & Gynecology

Increased expression of integrin-linked kinase during decidualization regulates the morphological transformation of endometrial stromal cells

Chih-Feng Yen et al.

FERTILITY AND STERILITY (2017)

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Article Developmental Biology

Emerging role for dysregulated decidualization in the genesis of preeclampsia

Kirk P. Conrad et al.

PLACENTA (2017)

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Article Multidisciplinary Sciences

Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology

Tamara Garrido-Gomez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Reproductive Biology

The Study of Cyclooxygenase 2 in Human Decidua of Preeclampsia

Dongmei Zhang et al.

BIOLOGY OF REPRODUCTION (2016)

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Article Endocrinology & Metabolism

Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts

Melissa L. McCallum et al.

ENDOCRINOLOGY (2016)

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Article Multidisciplinary Sciences

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

Yasuaki Kabe et al.

NATURE COMMUNICATIONS (2016)

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Article Endocrinology & Metabolism

EPAC2-mediated calreticulin regulates LIF and COX2 expression in human endometrial glandular cells

Kazuya Kusama et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2015)

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Review Endocrinology & Metabolism

Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure

Birgit Gellersen et al.

ENDOCRINE REVIEWS (2014)

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Article Obstetrics & Gynecology

Biomarkers of endothelial dysfunction in preeclampsia and neonatal morbidity: a case-control study

Sophia Masoura et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2014)

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Review Biochemistry & Molecular Biology

Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

Petra C. Arck et al.

NATURE MEDICINE (2013)

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Article Reproductive Biology

A Novel Role for Progesterone and Progesterone Receptor Membrane Component 1 in Regulating Spindle Microtubule Stability During Rat and Human Ovarian Cell Mitosis

Valentina Lodde et al.

BIOLOGY OF REPRODUCTION (2011)

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Review Medicine, Research & Experimental

Uterine disorders and pregnancy complications: insights from mouse models

Hyunjung Jade Lim et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

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Article Pharmacology & Pharmacy

Progesterone Receptor Membrane Component 1 (Pgrmc1): A Heme-1 Domain Protein That Promotes Tumorigenesis and Is Inhibited by a Small Molecule

Ikhlas S. Ahmed et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

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Article Biochemistry & Molecular Biology

Knockdown of IGF-Binding Protein 7 Inhibits Transformation of the Endometrial Gland in an In Vitro Model

Masahiko Kutsukake et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2010)

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Article Endocrinology & Metabolism

Stathmin, a Microtubule Regulatory Protein, Is Associated with Hypoxia-Inducible Factor-1α Levels in Human Endometrial and Endothelial Cells

Mikihiro Yoshie et al.

ENDOCRINOLOGY (2009)

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Article Endocrinology & Metabolism

Progesterone Activates a Progesterone Receptor Membrane Component 1-Dependent Mechanism That Promotes Human Granulosa/Luteal Cell Survival But Not Progesterone Secretion

John J. Peluso et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

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Article Cell Biology

The NF-κB Family of Transcription Factors and Its Regulation

Andrea Oeckinghaus et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

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Article Developmental Biology

Cyclooxygenase-2 derived PGE2 and PG12 play an important role via EP2 and PPARδ receptors in early steps of oil induced decidualization in mice

P. L. Pakrasi et al.

PLACENTA (2008)

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Article Endocrinology & Metabolism

Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells

Masashi Takano et al.

MOLECULAR ENDOCRINOLOGY (2007)

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Review Obstetrics & Gynecology

Endometrial receptivity markers, the journey to successful embryo implantation

Hanna Achache et al.

HUMAN REPRODUCTION UPDATE (2006)

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Article Obstetrics & Gynecology

Cytokine expression in the endometrium of women with implantation failure and recurrent miscarriage

Susan Laird et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2006)

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Review Endocrinology & Metabolism

Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair

B Gellersen et al.

JOURNAL OF ENDOCRINOLOGY (2003)

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Article Pathology

Successful immortalization of endometrial glandular cells with normal structural and functional characteristics

S Kyo et al.

AMERICAN JOURNAL OF PATHOLOGY (2003)

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Review Biochemistry & Molecular Biology

Cyclooxygenase isozymes and their gene structures and expression

T Tanabe et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2002)

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Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells

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