Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Atractylodes oil on Spleen Yang Deficiency Syndrome in rats

Article Gastroenterology & Hepatology

Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease

Tianyi Chen et al.

Summary: This study investigates the role of Smoothened (Smo), an obligatory component of the Hedgehog signaling pathway, in controlling hepatocyte metabolic homeostasis and susceptibility to NASH.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2023)

添加到收藏夹

Article Plant Sciences

Deep-fried Atractylodes lancea rhizome alleviates spleen deficiency diarrhea-induced short-chain fatty acid metabolic disorder in mice by remodeling the intestinal flora

Chunlian Liu et al.

Summary: This study aimed to investigate the therapeutic effect of deep-fried Atractylodes lancea on spleen deficiency-induced diarrhea and its regulation on short-chain fatty acid metabolism induced by intestinal flora. The results showed that deep-fried Atractylodes lancea could alleviate the symptoms of spleen deficiency-induced diarrhea and improve the levels of short-chain fatty acids through modulation of intestinal flora metabolism.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation

Yimeng Fan et al.

Summary: Through the experiment, it was found that Pingwei San (PWS) could increase body weight, reduce fecal water content, and decrease inflammatory cell infiltration in the colon. Additionally, PWS promoted the expression of AQPs and tight junction markers and prevented the loss of colonic cup cells. Furthermore, PWS significantly increased the abundance of Prevotellaceae, Eubacterium_ruminantium_group, and Tuzzerella, while decreasing the abundance of Ruminococcus and Frisingicoccus in the feces of SDD rats.

ANTIOXIDANTS (2023)

添加到收藏夹

Article Integrative & Complementary Medicine

Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites

Linghang Qu et al.

Summary: This study compared the therapeutic effects and mechanisms of raw Atractylodes lancea and bran-fried Atractylodes lancea on dextran sulfate sodium-induced ulcerative colitis in mice. The results showed that both preparations alleviated colitis symptoms, inhibited inflammation and restored gut microbial balance. Bran-fried Atractylodes lancea had a better therapeutic effect than raw Atractylodes lancea.

AMERICAN JOURNAL OF CHINESE MEDICINE (2022)

添加到收藏夹

Article

Herbal Medicine Prescriptions for Functional Dyspepsia: A Nationwide Population-Based Study in Korea

Boram Lee et al.

Evidence-based Complementary and Alternative Medicine (2022)

添加到收藏夹

Article Psychiatry

Differences in mitochondrial DNA copy number between patients with bipolar I and II disorders

Jae Kyung Chung et al.

Summary: Mitochondrial dysfunction may explain the pathophysiology of bipolar disorder, with BD1 patients having lower mtDNA copy numbers and BD2 patients having higher mtDNA copy numbers compared to controls. Changes in mitochondrial function may influence the pathophysiology of BD, and the opposite directions of the association with mtDNA copy number in BD1 and BD2 patients suggest a potential link between pathophysiological differences and mitochondrial function.

JOURNAL OF PSYCHIATRIC RESEARCH (2022)

添加到收藏夹

Article Cell Biology

Studies on the Mechanism of the Volatile Oils from Caoguo-4 Decoction in Regulating Spleen Deficiency Diarrhea by Adjusting Intestinal Microbiota

Li Mei et al.

Summary: This study found that the volatile oil from the Caoguo-4 decoction has antidiarrheal effects in a spleen deficiency diarrhea (SDD) model. It improves serum indicators and intestinal mucosal structure, while also restoring the richness and diversity of the gut microbiota.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Metabolic Regulation of Macrophages by SIRT1 Determines Activation During Cholestatic Liver Disease in Mice

Anna Isaacs-Ten et al.

Summary: The study revealed that overexpression of SIRT1 promotes liver inflammation and injury in cholestatic liver disease, which is associated with increased activation of the inflammasome in macrophages. Mechanistically, SIRT1 overexpression activates the mTOR pathway in macrophages, leading to metabolic rewiring and impaired tricarboxylic acid cycle.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Growth hormone receptor gene influences mitochondrial function and chicken lipid metabolism by AMPK-PGC1α-PPAR signaling pathway

Minmin Yang et al.

Summary: This study demonstrates that GHR promotes mitochondrial function and inhibits lipid peroxidation as well as fat deposition in chickens, and it is essential for maintaining the stability of lipid metabolism and regulating mitochondrial function.

BMC GENOMICS (2022)

添加到收藏夹

Article Immunology

Atractyloside-A ameliorates spleen deficiency diarrhea by interfering with TLR4/MyD88/NF-κB signaling activation and regulating intestinal flora homeostasis

Jing Xu et al.

Summary: This study found that AA treated SDD by regulating intestinal flora and inflammation through the TLR4/MyD88/NF-kappa B signaling pathway. AA improved the integrity of the intestinal barrier, alleviated pathological symptoms, and suppressed intestinal inflammatory responses.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Plant Sciences

Preventive effect of Atractylodis Rhizoma extract on DSS-induced acute ulcerative colitis through the regulation of the MAPK/NF-?B signals in vivo and in vitro

Xiong Lin et al.

Summary: Ethanol extract of Atractylodis Rhizoma (EEAR) ameliorates dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) by inhibiting the inflammatory response and maintaining the intestinal barrier function. EEAR could be a promising therapeutic candidate for UC therapy.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

添加到收藏夹

Article Cell Biology

Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1α

Jieru Han et al.

Summary: The study demonstrated that AT III could protect against ulcerative colitis by attenuating mitochondrial dysfunction through the activation of the AMPK/SIRT1/PGC-1 alpha signaling pathway. Both in vivo and in vitro results supported the anti-inflammatory effects of AT III on UC development.

MEDIATORS OF INFLAMMATION (2022)

添加到收藏夹

Article Plant Sciences

Atractylenolide-1 targets SPHK1 and B4GALT2 to regulate intestinal metabolism and flora composition to improve inflammation in mice with colitis

Linghang Qu et al.

Summary: This study investigates the efficacy and mechanism of atractylenolide-1 in treating ulcerative colitis. The results show that atractylenolide-1 significantly improves symptoms and reduces inflammation in mice with colitis. It also regulates the intestinal flora and metabolism, making it a potential drug for colitis treatment.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Plant Sciences

Sheng Mai San ameliorated heat stress-induced liver injury via regulating energy metabolism and AMPK/Drp1-dependent autophagy process

Xiaosong Zhang et al.

Summary: This study comprehensively investigated the pharmacological effect and molecular mechanisms of Sheng Mai San (SMS) on heat stress-induced liver injury using a combination of pharmacodynamics, targeted metabolomics, and molecular biology technology. The results demonstrated that SMS alleviates liver dysfunction and pathological damage caused by heat stress through regulating energy metabolism, suppressing inflammation and oxidative injury, and promoting mitophagy. These findings support the use of SMS in treating liver injury induced by heat stress.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Chemistry, Analytical

Intervention effects of ginseng on spleen-qi deficiency in rats revealed by GC-MS-based metabonomic approach

Ming Liu et al.

Summary: This study used metabolomic technique to investigate the therapeutic effect of ginseng on spleen-qi deficiency, and found that ginseng could regulate multiple metabolic pathways to achieve therapeutic effects.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

Lianhong Pan et al.

Summary: DML inhibits the tumorigenesis of liver cancer stem cells by suppressing H3 histone lactylation and exerts anti-tumor effects through regulating lactate metabolism.

PHARMACOLOGICAL RESEARCH (2022)

添加到收藏夹

Article Plant Sciences

Xiangsha Liujunzi Decoction improves gastrointestinal motility in functional dyspepsia with spleen deficiency syndrome by restoring mitochondrial quality control homeostasis

Jiaqi Zhang et al.

Summary: This study demonstrated that XSLJZD can improve gastrointestinal motility disorder in functional dyspepsia with spleen deficiency syndrome by restoring mitochondrial function and morphology. XSLJZD treatment promoted the contraction of gastric smooth muscle and inhibited PINK1/Parkin-mediated mitophagy and division, illustrating the important role of mitochondrial quality control in treating gastrointestinal motility disorder.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Ganfule capsule alleviates bile duct ligation-induced liver fibrosis in mice by inhibiting glutamine metabolism

Chang Ke et al.

Summary: This study aimed to investigate the protective effect of Ganfule capsule (GFL) on liver fibrosis and its possible mechanism. The cholestatic liver fibrosis model was prepared by bile duct ligation (BDL) in mice. The results showed that GFL could alleviate liver injury and fibrosis caused by BDL. Metabonomic analysis revealed metabolic disorder after surgery, which could be alleviated by GFL through regulation of glutamine metabolism and other pathways. GFL inhibited the activity of glutaminase 1 (GLS1) and the NF-kappa B pathway, leading to the alleviation of liver fibrosis.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Hepatic Kruppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance

Nannan Sun et al.

Summary: The transcription factor KLF16 plays a crucial role in hepatic lipid metabolism by regulating fatty acid oxidation and improving mitochondrial stress and oxidative stress, thus reducing hepatic steatosis and insulin resistance.

GUT (2021)

添加到收藏夹

Article Chemistry, Analytical

Label-free mass spectrometry-based proteomics for investigating the therapeutic mechanism of Sijunzi decoction on spleen deficiency syndrome

Qinghua Yan et al.

Summary: Sijunzi decoction, a classic prescription in traditional Chinese medicine, was found to restore damaged liver tissue and enzymatic activities, mainly regulating metabolic processes and being closely related to bile secretion, pyruvate metabolism, cysteine and methionine metabolism, and fatty acid metabolism pathways in the intervention of spleen deficiency syndrome. Prominent proteins like H2afx, ISG15, and STAT1 were predicted to play important roles in the action networks of Sijunzi decoction. This study offers novel perspectives for understanding the therapeutic mechanisms of Sijunzi decoction on spleen deficiency syndrome.

MICROCHEMICAL JOURNAL (2021)

添加到收藏夹

Article Plant Sciences

Metabolomics of Spleen-Yang deficiency syndrome and the therapeutic effect of Fuzi Lizhong pill on regulating endogenous metabolism

Zhen Zhang et al.

Summary: The study investigated the essence of Spleen-Yang deficiency (SYD) through metabolomics and revealed the anti-SYD action mechanisms of Fuzi Lizhong pill (FLZP). Results showed that FLZP regulated biomarkers related to SYD, alleviating diarrhea and gastrointestinal motility disorder, and exhibiting anti-peroxidation, anti-inflammatory, and immune regulation effects.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Glycine ameliorates mitochondrial dysfunction caused by ABT-199 in porcine oocytes

Sicong Yu et al.

Summary: In this study, a mitochondrial damage model was induced in porcine oocytes with the Bcl-2-specific antagonist ABT-199, and the protective effects of glycine (Gly) against ABT-199-induced mitochondrial dysfunction were investigated. Gly was found to significantly ameliorate mitochondrial dysfunction, oxidative stress, and apoptosis, as well as regulate intracellular calcium levels and IP(3)R1 cellular distribution, thereby protecting oocyte maturation.

JOURNAL OF ANIMAL SCIENCE (2021)

添加到收藏夹

Article Plant Sciences

Differential effect of polysaccharide and nonpolysaccharide components in Sijunzi decoction on spleen deficiency syndrome and their mechanisms

Ping Ma et al.

Summary: The study revealed that Sijunzi decoction (SJZD) has a stronger therapeutic effect on intestinal immune and GI hormone secretion in SDS rats, while the effectiveness of NPS and S-3 showed slight differences. NPS mainly regulates GI hormone secretion and directly improves intestinal immunity, whereas S-3 enhances intestinal immunity by increasing T lymphocyte cell expression and repairing the intestinal barrier directly and indirectly. Additionally, the modulation effect of the gut microbiota plays a crucial role in the treatment of SDS with SJZD, NPS, and S-3.

PHYTOMEDICINE (2021)

添加到收藏夹

Article Food Science & Technology

Untargeted fecal metabolomics revealed biochemical mechanisms of the blood lipid-lowering effect of koumiss treatment in patients with hyperlipidemia

Bohai Li et al.

Summary: This study aimed to investigate the biochemical mechanism of the lipid-lowering effect of consuming koumiss daily by analyzing the fecal metabolomes of hyperlipidemia patients before and after koumiss treatment. Ten significant differential metabolites were detected, showing increased concentrations at days 30 and 60, many of which were involved in lipid metabolism and transport. The metabolites identified were likely associated with the observed lipid-lowering effect.

JOURNAL OF FUNCTIONAL FOODS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

An Integrated Gut Microbiota and Network Pharmacology Study on Fuzi-Lizhong Pill for Treating Diarrhea-Predominant Irritable Bowel Syndrome

Zhen Zhang et al.

Summary: Fuzi-Lizhong pill (FLZP) is a traditional Chinese medicine with good clinical effect on diarrhea-predominant irritable bowel syndrome (IBS-D). It mainly treats IBS-D by regulating gut microbiota, influencing inflammation, and immune system.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

AMPK, metabolism, and vascular function

Claudia Rodriguez et al.

Summary: AMPK serves as a crucial cellular energy sensor activated during energy stress, playing a key role in maintaining energy homeostasis. It is involved in various functions such as mitochondrial biogenesis, redox regulation, cell growth, autophagy, and inflammation. Recent studies have highlighted the protective role of AMPK in cardiovascular function and its association with cardiovascular disease pathogenesis.

FEBS JOURNAL (2021)

添加到收藏夹

Article Plant Sciences

Atractylodes oil alleviates diarrhea-predominant irritable bowel syndrome by regulating intestinal inflammation and intestinal barrier via SCF/c-kit and MLCK/MLC2 pathways

Ying Xie et al.

Summary: This study confirmed the therapeutic effect of Atractylodes lanceolata oil (AO) in a rat model of IBS-D, showing that AO inhibits the SCF/c-kit pathway to reduce inflammation and protects against intestinal barrier damage via the MLCK/MLC2 pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Inborn disorders of the malate aspartate shuttle

Melissa H. Broeks et al.

Summary: The malate aspartate shuttle (MAS) is crucial for mitochondrial respiration and maintaining cytosolic redox balance, playing a key role in sustaining metabolic pathways like glycolysis and serine biosynthesis. Five potential MAS deficiencies have been reported, mostly presenting with infantile epileptic encephalopathy. Biochemical characteristics such as high lactate, disturbed redox balance, and low serine can aid in diagnosis, while treatment options include a ketogenic diet, serine, and vitamin B6 supplementation.

JOURNAL OF INHERITED METABOLIC DISEASE (2021)

添加到收藏夹

Article Plant Sciences

Digestive promoting effect and mechanism of Jiao Sanxian in rats

Ying Liu et al.

Summary: Jiao Sanxian, a classic prescription for the treatment of functional dyspepsia, is believed to enhance digestion and improve stagnation of digestive system. The mechanism of action may involve regulating secretion of brain gut peptides, improving disorder of intestinal flora, and ameliorating multi-metabolic pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α

Yufei Zhou et al.

Summary: The study shows that NOB can alleviate pathological cardiac remodeling after MI by upregulating PPAR gamma and PGC1 alpha, reducing cardiac fibrosis, apoptosis, and hypertrophy.

PPAR RESEARCH (2021)

添加到收藏夹

Article Respiratory System

PINK1/Parkin-mediated mitophagy in mechanical ventilation-induced diaphragmatic dysfunction

Hui Yong et al.

Summary: The study revealed that mechanical ventilation may induce diaphragmatic dysfunction by activating mitophagy, leading to changes in mitochondrial dynamics and subsequent diaphragmatic dysfunction and muscle atrophy.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2021)

添加到收藏夹

Article Cell Biology

Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria

Oya Altinok et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Deep-Fried Atractylodis Rhizoma Protects against Spleen Deficiency-Induced Diarrhea through Regulating Intestinal Inflammatory Response and Gut Microbiota

Kun Shi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Chemistry, Analytical

Metabolomics analysis reveals the mechanisms of the effect of Sijunzi decoction on spleen deficiency syndrome in a rat model

Yan Qinghua et al.

MICROCHEMICAL JOURNAL (2020)

添加到收藏夹

Article Agriculture, Multidisciplinary

Threonine, but Not Lysine and Methionine, Reduces Fat Accumulation by Regulating Lipid Metabolism in Obese Mice

Qingquan Ma et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Analytical

Metabolomic study of raw and bran-fried Atractylodis Rhizoma on rats with spleen deficiency

Bei-xue Zhang et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)

添加到收藏夹

Article Plant Sciences

Application of RRLC-QTOF-MS-based metabonomics and UPE for investigating Spleen-Qi deficiency syndrome with Panax ginseng treatment

Ni Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Traditional Chinese medicine Lingguizhugan decoction treating non-alcoholic fatty liver disease with spleen-yang deficiency pattern: Study protocol for a multicenter randomized controlled trial

Jingjuan Xu et al.

TRIALS (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Integrating Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Citri Reticulatae Pericarpium Against Reserpine-Induced Spleen Deficiency in Rats

Yuying Zheng et al.

FRONTIERS IN PHARMACOLOGY (2020)

添加到收藏夹

Article Plant Sciences

Panax ginseng root, not leaf, can enhance thermogenic capacity and mitochondrial function in mice

Su-hui Wu et al.

PHARMACEUTICAL BIOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

The effects of aqueous extract of Maca on energy metabolism and immunoregulation

Wenting Fei et al.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2020)

添加到收藏夹

Review Nutrition & Dietetics

Essential Fatty Acid Requirements and Intravenous Lipid Emulsions

Leah Gramlich et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2019)

添加到收藏夹

Article Plant Sciences

Child compound Endothelium corneum attenuates gastrointestinal dysmotility through regulating the homeostasis of brain-gut-microbiota axis in functional dyspepsia rats

Yixin He et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

添加到收藏夹

Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis

Melis Karaca et al.

DIABETES (2018)

添加到收藏夹

Article Chemistry, Medicinal

Comparison of Bran-Processed and Crude Atractylodes Lancea Effects on Spleen Deficiency Syndrome in Rats

Dong-Hua Xue et al.

PHARMACOGNOSY MAGAZINE (2018)

添加到收藏夹

Article Integrative & Complementary Medicine

Plasma metabolomics coupled with MetaboAnalyst and Ingenuity Pathway Analysis characterizes linoleic acid metabolism disorder in patients with spleen-yang-deficiency syndrome

Zhang Lin et al.

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Integrative metabolic and microbial profiling on patients with Spleen-yang-deficiency syndrome

Zhang Lin et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Chemistry, Medicinal

Beneficial Effects of the Amino Acid Glycine

Israel Perez-Torres et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Plant Sciences

The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats

Hang Xiao et al.

JOURNAL OF GINSENG RESEARCH (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Protective effect of polysaccharides fractions from Sijunzi decoction in reserpine-induced spleen deficiency rats

Ruijun Wang et al.

RSC ADVANCES (2016)

添加到收藏夹

Review Endocrinology & Metabolism

PPAR gamma gene - A review

C. Janani et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2015)

添加到收藏夹

Article Cell Biology

The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism

Egon Demetz et al.

CELL METABOLISM (2014)

添加到收藏夹

Meeting Abstract Biochemistry & Molecular Biology

Body energy metabolism and oxidative stress in mice supplemented with conjugated linoleic acid (CLA) associated to oleic acid

Baraldi Flavia et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

添加到收藏夹

Article Plant Sciences

Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

Xiao-fen Zheng et al.

JOURNAL OF ETHNOPHARMACOLOGY (2014)

添加到收藏夹

Article Integrative & Complementary Medicine

Biofeedback Therapy Combined with Traditional Chinese Medicine Prescription Improves the Symptoms, Surface Myoelectricity, and Anal Canal Pressure of the Patients with Spleen Deficiency Constipation

Yi-Bo Yao et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

添加到收藏夹

Article Cell Biology

High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia

Julieta Carabelli et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)

添加到收藏夹

Article Plant Sciences

Effects on neuroendocrinoimmune network of Lizhong Pill in the reserpine induced rats with spleen deficiency in traditional Chinese medicine

Ning Zhao et al.

JOURNAL OF ETHNOPHARMACOLOGY (2011)

添加到收藏夹

Review Endocrinology & Metabolism

AMPK and SIRT1: a long-standing partnership?

Neil B. Ruderman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

添加到收藏夹

Article Agriculture, Multidisciplinary

Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease

Zhisen Pan et al.

Summary: The study demonstrates that ginsenoside Rc attenuates hepatocyte damage and oxidative stress in alcoholic liver disease by up-regulating the SIRT6/NRF2 pathway, showing promising potential as a treatment for ALD.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

添加到收藏夹

Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Atractylodes oil on Spleen Yang Deficiency Syndrome in rats

相关参考文献

导出引文

分享论文