4.1 Article

Systematic estimation of biological age of in vitro cell culture systems by an age-associated marker panel

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock

Christopher Minteer et al.

Summary: This study demonstrates that physiologically relevant aging changes can be induced in vitro and used to uncover mechanistic insights into epigenetic aging.

AGING CELL (2022)

Article Cell Biology

The relationship between epigenetic age and the hallmarks of aging in human cells

Sylwia Kabacik et al.

Summary: Epigenetic clocks are age estimators based on methylation values at specific CpGs in the genome. This study investigates the relationship between epigenetic aging and the previously identified aging hallmarks, and finds associations with nutrient sensing, mitochondrial activity, and stem cell composition.

NATURE AGING (2022)

Article Cell Biology

Nuclear morphology is a deep learning biomarker of cellular senescence

Indra Heckenbach et al.

Summary: A deep learning predictor based on nuclear morphology can identify senescent cells and is associated with health outcomes in humans.

NATURE AGING (2022)

Review Multidisciplinary Sciences

The central role of DNA damage in the ageing process

Bjoern Schumacher et al.

Summary: Ageing is a complex process that affects every organ and tissue in the body, but the causal mechanism behind it remains unclear. Accumulating evidence suggests that DNA damage may play a central role in driving ageing, providing a potential unified approach to combat age-related diseases.

NATURE (2021)

Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Genetics & Heredity

Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring

Alexander Hartmann et al.

Summary: The review provides an overview of commonly mentioned and frequently used potential aging-related biomarkers, with a focus on biomarkers related to cellular senescence. Two scoring systems are introduced to reflect biomarker relevance and measurement effort, supporting study designs in both clinical and research settings.

FRONTIERS IN GENETICS (2021)

Review Biochemical Research Methods

Aging Biomarkers: From Functional Tests to Multi-Omics Approaches

Ksenia S. Kudryashova et al.

PROTEOMICS (2020)

Article Cardiac & Cardiovascular Systems

Metabolic Age Based on the BBMRI-NL H-1-NMR Metabolomics Repository as Biomarker of Age-related Disease

Erik B. van den Akker et al.

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

Cardiovascular Risks Associated with Gender and Aging

Jennifer L. Rodgers et al.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2019)

Review Geriatrics & Gerontology

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways

Georg Fuellen et al.

AGING AND DISEASE (2019)

Article Biotechnology & Applied Microbiology

Predicting age from the transcriptome of human dermal fibroblasts

Jason G. Fleischer et al.

GENOME BIOLOGY (2018)

Article Multidisciplinary Sciences

Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin

Audrey Shimei Wang et al.

SCIENTIFIC REPORTS (2017)

Review Medicine, General & Internal

Biological Age Predictors

Juulia Jylhava et al.

EBIOMEDICINE (2017)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Cell & Tissue Engineering

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

Justine D. Miller et al.

CELL STEM CELL (2013)

Article Biochemistry & Molecular Biology

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

Gregory Hannum et al.

MOLECULAR CELL (2013)

Article Biotechnology & Applied Microbiology

DNA methylation age of human tissues and cell types

Steve Horvath

GENOME BIOLOGY (2013)

Review Cell Biology

Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly

Micah Webster et al.

JOURNAL OF CELL SCIENCE (2009)

Article Biochemistry & Molecular Biology

Telomere length measurement by a novel monochrome multiplex quantitative PCR method

Richard M. Cawthon

NUCLEIC ACIDS RESEARCH (2009)

Review Biochemistry & Molecular Biology

Cellular senescence in cancer and aging

Manuel Collado et al.

Article Multidisciplinary Sciences

Age-related changes of nuclear architecture in Caenorhabditis elegans

E Haithcock et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

BC Capell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)