期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 128, 期 -, 页码 165-171出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2015.02.031
关键词
Cysteine modified; Sodium cholate; Micelles; Paclitaxel; Oral
资金
- Natural Science Foundation for Young Scholar of Shandong Province [ZR2013HQ011]
- Young Star of Science and Technology Project of Jinan [201406016]
The aim of the present study is to construct a cysteine modified polyion complex micelles made of Pluronic F127-chitosan (PF127-CS), Pluronic F127-cysteine (PF127-cysteine) and sodium cholate (NaC) and to evaluate the potential of the micelles as an oral drug delivery system for paclitaxel. Systematic studies on physicochemical properties including size distribution, zeta-potential and morphology were conducted to validate the formation of micelle structure. Compared with Pluronic micelles, drug-loading capacity of PF127-CS/PF127-cysteine/NaC micelles was increased from 3.35% to 12.77%. Both the critical micelle concentration and the stability test confirmed that the PF127-CS/PF127-cysteine/NaC micelles were more stable in aqueous solution than sodium cholate micelles. Pharmacokinetic study demonstrated that when oral administration the area under the plasma concentration-time curve (AUC(0-infinity)) and the absolute bioavailability of paclitaxel-loaded micelles were five times greater than that of the paclitaxel solution. In general, PF127-CS/PF127-cysteine/NaC micelles were proven to be a potential oral drug delivery system for paclitaxel. (c) 2015 Elsevier B.V. All rights reserved.
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