Aeromonas hydrophila causes ferroptotic damage via its secreted effectors targeting splenic macrophages in teleost

Review Biochemistry & Molecular Biology

Imbalanced GSH/ROS and sequential cell death

Ting Liu et al.

Summary: This article reviews the impact of imbalance between ROS and GSH on cells, indicating that imbalance may lead to cell death. In addition, different factors leading to the disruption of cellular ROS and GSH balance are introduced.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022)

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Review Cell Biology

Interaction between macrophages and ferroptosis

Yan Yang et al.

Summary: Ferroptosis is a newly discovered iron-dependent cell death pathway characterized by lipid peroxidation and GSH depletion, participating in the development of various diseases. Macrophages, as immune cells, play crucial roles in regulating iron, lipid, and amino acid metabolisms, and recent studies target their polarization to induce ferroptosis in cancer cells for treatment.

CELL DEATH & DISEASE (2022)

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Review Microbiology

Aeromonas and Human Health Disorders: Clinical Approaches

Rafael Bastos Goncalves Pessoa et al.

Summary: Aeromonas is a genus of Gram-negative bacteria that naturally inhabit aquatic environments and are commonly regarded as pathogens of fish and other animals. They have gained attention in medical trials due to their ability to colonize and infect humans. They are widely spread on various sources such as water, soil, vegetables, and food. The main clinical manifestations include gastrointestinal disorders, wound and soft tissue infections, and septicemia. Aeromonas species, such as A. hydrophila, A. caviae, and A. veronii biovar sobria, are considered potential human pathogens. The bacteria show a diversified susceptibility profile and inherent resistance to ampicillin. Further research is needed to fully understand the infectious processes and develop effective approaches for detection and medical intervention.

FRONTIERS IN MICROBIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Summary: This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.

CELL (2022)

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Article Biochemistry & Molecular Biology

The Antivirulence Activity of Umbelliferone and Its Protective Effect against A. hydrophila-Infected Grass Carp

Ling Zhao et al.

Summary: This study investigated the effects of umbelliferone on the virulence factors and quorum-sensing system of A. hydrophila, a pathogen that mainly harms aquatic animals. The results showed that umbelliferone could inhibit the virulence of A. hydrophila and reduce the bacterial load in infected grass carp. These findings suggest that umbelliferone has the potential to be used as a drug for treating A. hydrophila infection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biotechnology & Applied Microbiology

Antibiotic resistance and virulence factor gene profile of A. hydrophila isolated from carp (Cyprinidae) suspected with hemorrhagic septicemia in Gilan, Iran

Ali Goudarztalejerdi et al.

Summary: This study determined the antibacterial resistance profile of Aeromonas hydrophila isolates from carp in Gilan, Iran and investigated the presence of integrons, antibiotic resistance genes (ARG), and virulence factor genes (VFG) among these isolates. The study found a positive association between the presence of VFGs and antibiotic resistance, with MDR isolates showing high frequencies of VFGs.

LETTERS IN APPLIED MICROBIOLOGY (2022)

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Article Immunology

Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to Bacillus Calmette-Guerin infection

Chenjie Ma et al.

Summary: The study revealed that HO-1 is a crucial regulator of Mtb-induced ferroptosis in macrophages, controlling ROS production and iron accumulation to alter macrophage death against Mtb infections.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Gut microbiota-mediated ferroptosis contributes to mercury exposure-induced brain injury in common carp

Yue Zhang et al.

Summary: This study found that mercury exposure could induce brain injury and memory loss in common carp, partly through inducing neuronal ferroptosis and increasing the abundance of Aeromonas, a pathogenic bacterium, in the gut.

METALLOMICS (2022)

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Article Fisheries

Escherichia coli induced ferroptosis in red blood cells of grass carp (Ctenopharyngodon idella)

Minxuan Yang et al.

Summary: The study revealed that fish red blood cells are not only responsible for oxygen transportation, but also potentially play a role in immune response against bacterial infections. After incubation with E. coli, grass carp RBCs showed changes in gene expression, activating various immune responses.

FISH & SHELLFISH IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Functions of ROS in Macrophages and Antimicrobial Immunity

Marc Herb et al.

Summary: Reactive oxygen species (ROS) play essential roles in various cellular processes, including antimicrobial activity and immune signaling regulation. However, in-depth studies on ROS and their regulated target molecules are still limited. This review provides an overview of ROS sources, functions, and related probes, scavengers, and inhibitors.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO' sabotage of theft-ferroptosis

Haider H. Dar et al.

Summary: The research found that Pseudomonas aeruginosa degrades host GPx4 defense through activating lysosomal chaperone-mediated autophagy, leading to the activation of the host's anti-ferroptotic mechanism driven by iNOS/NO'. Macrophage-produced NO' can distantly prevent P. aeruginosa-induced ferroptosis in epithelial cells by suppressing phospholipid peroxidation.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology