Modified Shoutai Pill inhibited ferroptosis to alleviate recurrent pregnancy loss

Article Plant Sciences

Shoutai Wan regulates glycolysis imbalance at the maternal-fetal interface in threatened abortion mice

Li Zhang et al.

Summary: Traditional Chinese medicine Shoutai Wan (STW) can reduce the embryo loss rate in threatened abortion model mice by regulating metabolic balance at the maternal-fetal interface.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

添加到收藏夹

Article Oncology

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

Peng Liao et al.

Summary: T cell-derived interferon gamma (IFN γ) in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mechanism for CD8(+) T cell-mediated tumor killing. This process involves IFN γ stimulation of ACSL4 and alteration of tumor cell lipid pattern.

CANCER CELL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Shumin Ouyang et al.

Summary: Inhibition of STAT3 can trigger ferroptosis and provide a new therapeutic strategy for gastric cancer and chemotherapy resistance. STAT3 negatively regulates the FNR associated genes and establishes a negative STAT3-ferroptosis regulatory axis in gastric cancer. A selective STAT3 inhibitor, W1131, shows significant anti-tumor effects in gastric cancer models by inducing ferroptosis and restores sensitivity to chemotherapy.

REDOX BIOLOGY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Materno-fetal iron transfer and the emerging role of ferroptosis pathways

Jonas Zaugg et al.

Summary: This review article summarizes the current knowledge on the principles and regulatory mechanisms of transplacental iron transport and discusses the impact of disturbed iron homeostasis on pregnancy conditions. It also highlights the significance of the emerging ferroptosis pathway and its role in regulating placental iron homeostasis, oxidative stress, and gestational diseases.

BIOCHEMICAL PHARMACOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Summary: This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.

CELL (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer

Jaewang Lee et al.

Summary: SLC7A11 is a cell transmembrane protein that plays a critical role in maintaining redox homeostasis and has implications in cancer development and treatment. Further understanding of its functions could lead to novel cancer therapeutics.

ANTIOXIDANTS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inactivation of Yes-Associated Protein Mediates Trophoblast Dysfunction: A New Mechanism of Pregnancy Loss Associated with Anti-Phospholipid Antibodies?

Zengshu Huang et al.

Summary: The presence of anti-phospholipid antibodies may lead to pregnancy complications by affecting the activity of Yes-associated protein (YAP) in trophoblast cells. This study found that aPL+/PM+ IgG reduced YAP expression and disrupted YAP activity, resulting in abnormalities in cell cycle, apoptosis, migration, and angiogenesis in trophoblast cells.

BIOMEDICINES (2022)

添加到收藏夹

Article Chemistry, Medicinal

Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity

Yuling Lai et al.

Summary: This study firstly demonstrated the involvement of ferroptosis in the pathogenesis of tubal pregnancy and showed that shikonin has the potential to treat tubal pregnancy by targeting ferroptosis.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

添加到收藏夹

Review Cell Biology

Ferroptosis: machinery and regulation

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. Lipoxygenase is the main promoter of ferroptosis, while GPX4 is the central repressor of this process.

AUTOPHAGY (2021)

添加到收藏夹

Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Pranavi Koppula et al.

Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

添加到收藏夹

Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

添加到收藏夹

Article Immunology

Changes in the Distribution of Intrauterine Microbiota May Attribute to Immune Imbalance in the CBA/JxDBA/2 Abortion-Prone Mice Model

Shiyu Bai et al.

Summary: The study found that microbial communities were present in the uterine cavity of CBA/J mice at both non-pregnant and pregnant stages when mated with BALB/c and DBA/2 male mice. The differential microbiome abundance may be linked to immune tolerance through binding to the NOD-like receptor. In the abortion-prone mouse model, lower IL 10 levels and higher TNF-alpha and INF-gamma levels were observed compared to the standard pregnancy model.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

Chengxian Xu et al.

Summary: Research shows that Gpx4 plays a crucial role in protecting Treg cells from lipid peroxidation and ferroptosis, regulating immune homeostasis and antitumor immunity. Deletion of Gpx4 can lead to lipid peroxidation and ferroptosis of Treg cells, affecting immune homeostasis and antitumor immunity. Neutralization of lipid peroxides and blockade of iron availability rescue ferroptosis of Gpx4-deficient Treg cells.

CELL REPORTS (2021)

添加到收藏夹

Article Cell Biology

The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy

Meihe Li et al.

Summary: This study observed excessive levels of ferroptosis and inflammasome activation in both rats' model and placental trophoblast cell model of oxidative stress. Silencing of NLRP1 inflammasome increased the expression levels of GSH and GPX4, while activation led to opposite results. The levels of NLRP1, NLRP3, IL-1 beta, and caspase-1 were positively correlated with ferroptosis, indicating a connection between ferroptosis and inflammasome expression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia

Heng Zhang et al.

REDOX BIOLOGY (2020)

添加到收藏夹

Article Cell Biology

Transferrin Receptor Is a Specific Ferroptosis Marker

Huizhong Feng et al.

CELL REPORTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

PLA2G6 guards placental trophoblasts against ferroptotic injury

Ofer Beharier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Medicine, General & Internal

Recurrent pregnancy loss

Evdokia Dimitriadis et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

添加到收藏夹

Article Obstetrics & Gynecology

Risk Factors and Outcomes of Recurrent Pregnancy Loss in Japan

Keiko Morita et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The chemical basis of ferroptosis

Marcus Conrad et al.

NATURE CHEMICAL BIOLOGY (2019)

添加到收藏夹

Review Cell Biology

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Lian-Jiu Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

添加到收藏夹

Article Peripheral Vascular Disease

Role of Mitochondrial Dysfunction and Reactive Oxygen Species in Mediating Hypertension in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia

Venkata Ramana Vaka et al.

HYPERTENSION (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative Stress in Preeclampsia and Placental Diseases

Rajaa Aouache et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Cell Biology

AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia

Xiaotao Yang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

添加到收藏夹

Review Obstetrics & Gynecology

Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia

Ali Taravati et al.

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

添加到收藏夹

Review Nutrition & Dietetics

Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy

Patsy M. Brannon et al.

NUTRIENTS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Omkar Zilka et al.

ACS CENTRAL SCIENCE (2017)

添加到收藏夹

Article Nutrition & Dietetics

Iron homeostasis during pregnancy

Allison L. Fisher et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

添加到收藏夹

Article Oncology

Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

Ryosuke Shintoku et al.

CANCER SCIENCE (2017)

添加到收藏夹

Review Obstetrics & Gynecology

Recurrent pregnancy loss: current perspectives

Hady El Hachem et al.

INTERNATIONAL JOURNAL OF WOMENS HEALTH (2017)

添加到收藏夹

Article Obstetrics & Gynecology

Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies

Kelly K. Ferguson et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

添加到收藏夹

Article Immunology

Expression and localization of collectins in feto-maternal tissues of human first trimester spontaneous abortion and abortion prone mouse model

A. K. Yadav et al.

IMMUNOBIOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

添加到收藏夹

Article Obstetrics & Gynecology

Evaluation and treatment of recurrent pregnancy loss: a committee opinion

FERTILITY AND STERILITY (2012)

添加到收藏夹

Article Pathology

miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue in Human Trophoblast Cell Lines Siderosis of Interstitial Trophoblasts as a Novel Pathology of Preterm Preeclampsia and Small-for-Gestational-Age Pregnancies

Deug-Chan Lee et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

添加到收藏夹

Review Cell Biology

The Importance of Antioxidant Micronutrients in Pregnancy

Hiten D. Mistry et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2011)

添加到收藏夹

Article Obstetrics & Gynecology

Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses

Carolyn R. Jaslow et al.

FERTILITY AND STERILITY (2010)

添加到收藏夹

Modified Shoutai Pill inhibited ferroptosis to alleviate recurrent pregnancy loss

相关参考文献

导出引文

分享论文