Recent developments on microwave-assisted organic synthesis of nitrogen- and oxygen-containing preferred heterocyclic scaffolds

In recent decades, the utilization of microwave energy has experienced an extraordinary surge, leading to the introduction of innovative and revolutionary applications across various fields of chemistry such as medicinal chemistry, materials science, organic synthesis and heterocyclic chemistry. Herein, we provide a comprehensive literature review on the microwave-assisted organic synthesis of selected heterocycles. We highlight the use of microwave irradiation as an effective method for constructing a diverse range of molecules with high yield and selectivity. We also emphasize the impact of microwave irradiation on the efficient synthesis of N- and O-containing heterocycles that possess bioactive properties, such as anti-cancer, anti-proliferative, and anti-tumor activities. Specific attention is given to the efficient synthesis of pyrazolopyrimidines-, coumarin-, quinoline-, and isatin-based scaffolds, which have been extensively studied for their potential in drug discovery. The article provides valuable insights into the recent synthetic protocols and trends for the development of new drugs using heterocyclic molecules. This review highlights recent developments in the microwave-assisted organic synthesis of N- and O-containing heterocycles with specific examples of pyrazolopyrimidines-, coumarin-, quinoline-, and isatin-based scaffolds and their associated biological activities.

Automated summary

This article provides a comprehensive literature review on the recent developments in the microwave-assisted organic synthesis of N- and O-containing heterocycles, with a specific focus on pyrazolopyrimidines-, coumarin-, quinoline-, and isatin-based scaffolds and their biological activities.