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The potential role of ferroptosis in COVID-19-related cardiovascular injury

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Medicine, General & Internal

COVID-19's immuno-pathology and cardiovascular diseases

Entezar Mehrabi Nasab et al.

Summary: The COVID-19 pandemic has caused millions of cases and deaths worldwide, making it the most important challenge in recent years. COVID-19, caused by a single-stranded RNA virus, results in respiratory distress syndrome, lung inflammation, cytokine storm, and fatalities. Various complications, including endothelial dysfunction, coagulation activation, thromboembolic events, and vascular disease, have been observed. Cardiovascular complications such as myocardial and stroke ischemia, pulmonary thromboembolism, systemic arterial, and deep vein thrombosis have also been reported. This review provides an overview of the immuno-pathological mechanisms and the impact of COVID-19 on the cardiovascular system, including the heart, blood vessels, coagulation system, and immune inflammation.

JOURNAL OF INVESTIGATIVE MEDICINE (2023)

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Article Virology

Evaluation the efficacy and safety of N-acetylcysteine inhalation spray in controlling the symptoms of patients with COVID-19: An open-label randomized controlled clinical trial

Yunes Panahi et al.

Summary: The aim of this study was to evaluate the effect and safety of N-acetylcysteine (NAC) inhalation spray in the treatment of patients with COVID-19. The results showed that NAC significantly reduced the mortality rate and improved inflammatory parameters and the development of respiratory failure in patients with COVID-19, but it did not affect the length of hospital stay or the need for ICU admission.

JOURNAL OF MEDICAL VIROLOGY (2023)

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Review Cardiac & Cardiovascular Systems

Long COVID and the cardiovascular system-elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases

Mariann Gyongyosi et al.

Summary: Long COVID is a global non-communicable epidemic characterized by long-lasting multiorgan symptoms after SARS-CoV-2 infection has subsided. This scientific document aims to provide insight into the cardiovascular manifestations of long COVID and the possible causes and therapeutic options available. Imaging has shown evidence of chronic perimyocarditis, arterial wall inflammation, and microthrombosis in certain patient populations. Understanding the underlying cellular and molecular mechanisms is crucial for the development of effective treatment strategies. However, current biomarkers are not highly predictive for the presence or outcome of long COVID.

CARDIOVASCULAR RESEARCH (2023)

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Review Cardiac & Cardiovascular Systems

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

Xuexian Fang et al.

Summary: Iron homeostasis is crucial for proper cardiac function, and iron imbalance is a common factor in various cardiovascular diseases. Ferroptosis, an iron-dependent regulated cell death, has been increasingly recognized as an important process underlying the pathogenesis and progression of cardiovascular diseases. Understanding the mechanisms of iron metabolism and ferroptosis regulation in cardiomyocytes may lead to improvements in disease management.

NATURE REVIEWS CARDIOLOGY (2023)

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Review Biochemistry & Molecular Biology

Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic

Gavin Y. Oudit et al.

Summary: ACE2 is the essential entry receptor for SARS-CoV and SARS-CoV-2, and it has become one of the most targeted human molecules in biomedicine due to the COVID-19 pandemic. ACE2 plays two crucial physiological roles: it alters peptide cascade balance as an enzyme and controls intestinal amino acid uptake as a chaperone. The tissue distribution of ACE2, influenced by comorbidities and sex, explains the wide range of coronaviruses' tropism and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics offer a universal strategy for preventing and treating SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses that exploit ACE2 as their cellular receptor.

CELL (2023)

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Article Cardiac & Cardiovascular Systems

Myocardial Involvement After Hospitalization for COVID-19 Complicated by Troponin Elevation: A Prospective, Multicenter, Observational Study

Jessica Artico et al.

Summary: This study aimed to assess the presence, nature, and extent of myocardial damage in hospitalized patients with troponin elevation and COVID-19. The study found that patients with COVID-19 and elevated cardiac troponin levels had more ventricular impairment and myocardial scar compared to the control group. However, the proportion of myocarditis was low and scar pathogenesis was diverse.

CIRCULATION (2023)

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Article Biochemistry & Molecular Biology

Long-term cardiovascular outcomes of COVID-19

Yan Xie et al.

Summary: Individuals with COVID-19, even those who were not hospitalized during the acute phase of the infection, are at an increased long-term risk of various cardiovascular disorders. A study using national healthcare databases found that beyond the first 30 days after infection, individuals with COVID-19 have an elevated risk of developing cerebrovascular disorders, heart diseases, and other cardiovascular complications. The risk increases depending on the care setting during the acute phase.

NATURE MEDICINE (2022)

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Article Pharmacology & Pharmacy

Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage

Tiago J. Costa et al.

Summary: This study demonstrates that SARS-CoV-2 infection impairs mitochondrial function and activates TLR9 signaling in endothelial cells, leading to inflammatory responses and endothelial dysfunction. Targeting mitochondrial metabolic pathways may offer new therapeutic strategies for COVID-19.

VASCULAR PHARMACOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID-19

Charlotte B. Ingul et al.

Summary: Three months after hospital discharge, patients who had COVID-19 showed mild impairment of right ventricular function and double the prevalence of diastolic dysfunction compared to controls. There was no evidence of an association between cardiac function and intensive care treatment, dyspnea, or fatigue. Ventricular arrhythmias were common, but their clinical significance remains unclear.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

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Review Biology

Therapeutic potential of induced iron depletion using iron chelators in Covid-19

Punnoth Poonkuzhi Naseef et al.

Summary: Ferritin plays a crucial role in maintaining iron metabolism in the body, and high levels of ferritin are associated with inflammation and prognosis of COVID-19. Iron chelators can effectively treat iron overload and have potential therapeutic effects on COVID-19 patients.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Review Immunology

Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis

Felicia Ceban et al.

Summary: Post-COVID-19 syndrome, characterized by persistent symptoms after resolution of acute infection, is associated with significant fatigue and cognitive impairment. This study aimed to quantify the proportion of individuals experiencing fatigue and cognitive impairment 12 or more weeks after COVID-19 diagnosis, and to explore the inflammatory and functional consequences of post-COVID-19 syndrome. The results showed that a significant proportion of individuals continue to experience fatigue and cognitive impairment even after 12 or more weeks of COVID-19 diagnosis. Additionally, some individuals showed elevated levels of inflammatory markers and significant functional impairment.

BRAIN BEHAVIOR AND IMMUNITY (2022)

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Article Cardiac & Cardiovascular Systems

SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells

Yuling Han et al.

Summary: This study investigates the impact of SARS-CoV-2 infection on the pacemaker cells of the heart, using a hamster model and human embryonic stem cells. The researchers found that the virus can infect the primary pacemaker cells in the heart and cause dysfunction. They also identified two drugs that can block the infection and virus-induced ferroptosis.

CIRCULATION RESEARCH (2022)

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Article Medicine, Research & Experimental

Glycolytic inhibitor 2-deoxy-D-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions

Anant Narayan Bhatt et al.

Summary: The glycolytic inhibitor 2-DG inhibits the replication of SARS-CoV-2 and reduces cytopathic effects in infected cells. It also leads to un-glycosylation of the spike protein, resulting in the production of defective progeny virions with compromised infective potential.

LIFE SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis at the intersection of lipid metabolism and cellular signaling

Deguang Liang et al.

Summary: This review provides a comprehensive analysis of the mechanisms and signaling pathways involved in ferroptosis, focusing on the impact of lipid metabolism and the potential for therapeutic strategies targeting this interaction.

MOLECULAR CELL (2022)

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Article Biotechnology & Applied Microbiology

Functional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosis

Jing Yang et al.

Summary: This study analyzed the expression of succinate dehydrogenase (SDH) genes in clear cell renal cell carcinoma (ccRCC) and found that SDHs were significantly downregulated in ccRCC tissues and correlated with ccRCC progression. Increased methylation and high SDH promoter mutation rates may be the cause of reduced SDH expression in ccRCC. The study also demonstrated that SDH inhibition dampened oxidative phosphorylation, reduced ferroptotic events, and restored ferroptotic cell death.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma

Chaoting Zhou et al.

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BIOENGINEERED (2022)

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Review Cardiac & Cardiovascular Systems

Roles of Ferroptosis in Cardiovascular Diseases

Yuting Guo et al.

Summary: Ferroptosis, an iron-dependent regulated cell death, has been shown to be closely related to various cardiovascular diseases. This article reviews the contributions of ferroptosis to cardiovascular diseases and discusses potential strategies for treating these diseases.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Review Cell Biology

Recent progress in ferroptosis: inducers and inhibitors

Yunxi Du et al.

Summary: Ferroptosis is a new iron-dependent form of programmed cell death, closely related to the pathophysiological processes of many diseases. Recent studies have identified key targets and regulators, which are of great significance for related research.

CELL DEATH DISCOVERY (2022)

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Article Oncology

Characterization of pyruvate metabolism and citric acid cycle patterns predicts response to immunotherapeutic and ferroptosis in gastric cancer

Xu Wang et al.

Summary: This study investigated the role of pyruvate metabolism and citric acid cycle patterns in the tumor microenvironment of gastric cancer. The findings suggest that these patterns can predict the response to immunotherapy and may accelerate the development of immunotherapeutic strategies for gastric cancer.

CANCER CELL INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62-Keap1-NRF2 pathway

Yanchun Li et al.

Summary: The study revealed that knockdown of CISD2 accelerated ferroptotic cell death induced by Erastin, characterized by increased lipid peroxidation, GSH exhaustion, and iron accumulation. CISD2 depletion enhanced lysosomal activity and activated ferritinophagy under Erastin exposure. Additionally, CISD2 knockdown inhibited the p62-Keap1-NRF2 pathway, leading to oxidative stress and ferroptosis.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Article Cardiac & Cardiovascular Systems

Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales

Rochelle Knight et al.

Summary: Incidence of vascular diseases remains elevated up to 49 weeks after COVID-19 diagnosis, with a faster decline for arterial thromboses than VTEs. Patients hospitalized with COVID-19, non-White individuals, and those without previous events are at higher risk. Policies to prevent severe COVID-19, including vaccination, early post-discharge review, risk factor control, and secondary preventive agents, are supported by these findings.

CIRCULATION (2022)

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Review Cell Biology

Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease

Lai-Hua Xie et al.

Summary: Ferroptosis is a regulated non-apoptotic cell death characterized by iron-dependence and the accumulation of lipid peroxidation. Excessive iron promotes the generation of soluble and lipid ROS through an iron-dependent Fenton reaction and lipoxygenase (LOX) enzyme activity, inducing ferroptosis. Cytosolic glutathione peroxidase 4 (cGPX4) and mitochondrial glutathione peroxidase 4 (mGPX4) serve as defense systems to detoxify lipid peroxidation in the cytoplasmic and mitochondrial membrane, respectively, defending against ferroptosis under normal conditions.

CELLS (2022)

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Review Medicine, General & Internal

COVID-19 and the cardiovascular system-current knowledge and future perspectives

Dimitrios G. Chatzis et al.

Summary: The COVID-19 pandemic has had a devastating impact on global populations, with high mortality rates attributed to the virus's influence on various physiological systems, including the respiratory, cardiovascular, and neurological systems. Emerging evidence suggests a propensity for the virus to attack the cardiovascular system, but the pathophysiological mechanisms for this and the resulting high morbidity and mortality, including cardiovascular complications, are still poorly understood. This mini review aims to provide an update on current knowledge and future research areas.

WORLD JOURNAL OF CLINICAL CASES (2022)

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Review Oncology

Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

NATURE REVIEWS CANCER (2022)

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Article Cell & Tissue Engineering

SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism

Romy Kronstein-Wiedemann et al.

Summary: SARS-CoV-2 infection directly affects erythroid precursor cells, causing disturbances in hemoglobin and iron metabolism, which exacerbates the severity of COVID-19 disease.

STEM CELL REVIEWS AND REPORTS (2022)

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Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Pranavi Koppula et al.

Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

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Article Nanoscience & Nanotechnology

Targeting Ferroptosis by Polydopamine Nanoparticles Protects Heart against Ischemia/Reperfusion Injury

Yabing Zhang et al.

Summary: The study demonstrates that the use of PDA NPs effectively reduces Fe(2+) deposition and lipid peroxidation in a myocardial I/R injury mouse model, leading to improved cardiac function and reduced infarct size. The findings highlight the therapeutic effects of PDA NPs against myocardial I/R injury by preventing ferroptosis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biochemistry & Molecular Biology

Sorafenib induces mitochondrial dysfunction and exhibits synergistic effect with cysteine depletion by promoting HCC cells ferroptosis

Yanchun Li et al.

Summary: The study reveals that sorafenib inhibits the viability, proliferation, and migration of HCC cells by inducing ferroptosis, which can be reversed by glutathione supplementation to reduce mitochondrial reactive oxygen species and lipid peroxides accumulation, enhancing HCC cells' vulnerability to sorafenib.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

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Article Oncology

FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis

Wanye Hu et al.

Summary: The study found that FTH is upregulated in multiple cancers such as LIHC, CHOL, HNSC compared to corresponding normal tissues. Serum ferritin levels are positively associated with the progression of hepatitis, cirrhosis, and hepatocellular carcinoma. FTH expression correlates with tumor grades, cancer stages, and prognosis of HCC.

CANCER CELL INTERNATIONAL (2021)

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Review Medicine, General & Internal

Myocarditis in COVID-19 patients: current problems

Donato Mele et al.

Summary: This brief review aims to summarize the current knowledge on myocarditis in COVID-19 patients and highlight issues related to diagnosis and treatment. There is a lack of information on the mechanisms, prevalence, prognosis, diagnosis, and therapy of myocarditis in the context of COVID-19.

INTERNAL AND EMERGENCY MEDICINE (2021)

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Article Biochemistry & Molecular Biology

LncRNA MEG3 suppresses PI3K/AKT/mTOR signalling pathway to enhance autophagy and inhibit inflammation in TNF-α-treated keratinocytes and psoriatic mice

Zhan-Li Tang et al.

Summary: The study reveals that downregulation of lncRNA MEG3 is associated with enhanced inflammation and suppressed autophagy in psoriasis, while overexpression of lncRNA MEG3 can reverse these effects, potentially through the PI3K/AKT/mTOR signaling pathway. Therefore, lncRNA MEG3 may serve as a therapeutic target for psoriasis.

CYTOKINE (2021)

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Article Medicine, General & Internal

Outcomes of COVID-19-positive acute coronary syndrome patients: A multisource electronic healthcare records study from England

Muhammad Rashid et al.

Summary: This study identified that 4% of hospitalized ACS patients in England had concurrent COVID-19 infection, and these patients presented with poorer clinical characteristics upon admission and had higher mortality rates.

JOURNAL OF INTERNAL MEDICINE (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Worldwide Survey of COVID-19-Associated Arrhythmias

Ellie J. Coromilas et al.

Summary: COVID-19 patients with cardiac complications, particularly cardiac arrhythmias, have high morbidity and mortality. The study revealed common cardiac comorbidities among patients with arrhythmias and most had no prior history of arrhythmia. Regional variations were observed in the types of arrhythmias and treatment approaches.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2021)

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Article Cell Biology

Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis

Roberta Nardacci et al.

Summary: The pathogenesis of SARS-CoV-2 is not entirely understood, but our study revealed profound ultrastructural changes in the infected cells and lungs of deceased COVID-19 patients, particularly involving the presence of abundant lipid droplets. This suggests a potential role of lipids in the pathogenesis of SARS-CoV-2 and highlights a new avenue for pharmacological treatment to combat the virus.

CELL DEATH & DISEASE (2021)

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Article Cell & Tissue Engineering

Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients

Hector Huerga Encabo et al.

Summary: This study demonstrates that severe COVID-19 patients in intensive care experience a significant decline in hemoglobin levels but an increase in circulating nucleated red cells, indicating a possible induction of stress erythropoiesis by SARS-CoV-2 infection. The research also shows that ACE2 expression peaks during erythropoiesis, making erythroid progenitors susceptible to infection by the virus. Furthermore, the study identifies early erythroid progenitors as the primary target cells for SARS-CoV-2 infection during erythropoiesis, highlighting how the virus can impact the clinical symptoms of severe COVID-19 patients.

STEM CELL REPORTS (2021)

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Review Medicine, Research & Experimental

The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators

Hosam M. Habib et al.

Summary: Iron overload is increasingly seen as a contributor to the pathogenesis of COVID-19, triggering inflammation, hypercoagulation, hyperferritinemia, and immune dysfunction. Iron chelators, including the naturally occurring lactoferrin, may hold therapeutic value in COVID-19 by modulating the immune response and blocking the entry of coronaviruses into host cells.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Lipid peroxidation as a hallmark of severity in COVID-19 patients

Marta Martin-Fernandez et al.

Summary: This study revealed the presence of oxidative stress in COVID-19 patients, with high levels of antioxidant enzymes and oxidative cell damage, while total antioxidant capacity was lower. Elevated lipid peroxidation (LPO) levels above 1948.17 mu M were independently associated with a higher risk of intubation or death at 28 days in COVID-19 patients.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

Xueying Ren et al.

Summary: DSF/Cu selectively exerts efficient cytotoxic effect on HCC cells, inhibits migration, invasion, and angiogenesis of HCC cells, impairs mitochondrial homeostasis, increases free iron pool, enhances lipid peroxidation, and eventually results in ferroptotic cell death. Inhibition of NRF2 elevation strengthens HCC cells more vulnerable to DSF/Cu induced ferroptosis.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin

Fumiya Ito et al.

Summary: The study proposed a novel mechanism in which extracellular vesicles mediate the transfer of mutagenic factors associated with asbestos to mesothelial cells. It was found that FedEVs transport iron from ferroptotic macrophages to mesothelial cells, contributing to asbestos-induced mesothelioma. Mesothelial cells receiving higher amounts of FedEVs were found to be in mitotic phases, particularly in S and G2/M phases.

REDOX BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19?

Anna Maria Fratta Pasini et al.

Summary: Understanding the molecular mechanisms of ferroptosis and its potential relationship with SARS-CoV-2 infection and multiorgan damage is crucial. By investigating interventions that combat ferroptosis, it may be possible to reduce the risk of multiorgan damage caused by COVID-19.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

NCOA4-Mediated Ferritinophagy: A Vicious Culprit in COVID-19 Pathogenesis?

Fengju Jia et al.

Summary: In COVID-19 patients, inflammatory reactions can lead to ferritinophagy and release of excess iron, promoting cell death. Targeting ferritinophagy may help limit cell death and prevent organ damage in severe cases of COVID-19.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Biochemistry & Molecular Biology

Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury

Jose Lillo-Moya et al.

Summary: Ischemic heart disease is a major cause of death globally, and reoxygenation is the primary treatment to restore blood flow, although it can also induce tissue injury. Iron-induced ferroptosis plays a critical role in heart damage, and efforts to inhibit it may improve clinical outcomes for patients.

ANTIOXIDANTS (2021)

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Article Cardiac & Cardiovascular Systems

COVID-19 myocarditis: quantitative analysis of the inflammatory infiltrate and a proposed mechanism *

Sharon E. Fox et al.

Summary: This study characterizes and quantifies the inflammatory cell infiltrate in COVID-19 patients' hearts and compares it with age and disease-matched controls and patients with typical inflammatory myocarditis. The results suggest that COVID-19 may cause a different form of myocarditis characterized by an increased number of CD68+ cells compared to typical viral myocarditis.

CARDIOVASCULAR PATHOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)

Edina Cenko et al.

Summary: COVID-19 significantly impacts the cardiovascular system, causing microvascular damage, endothelial dysfunction, and thrombosis. Pre-existing cardiovascular diseases and viral load are associated with myocardial injury and poor outcomes, potentially leading to post-acute complications.

CARDIOVASCULAR RESEARCH (2021)

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Article Food Science & Technology

SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis

Yijun Wang et al.

Summary: SARS-CoV-2 infection significantly suppressed the expression of a specific set of selenoprotein mRNAs in Vero cells, particularly affecting selenoproteins related to ferroptosis, DNA synthesis, and endoplasmic reticulum function.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Neurosciences

SARS-CoV-2 Neuronal Invasion and Complications: Potential Mechanisms and Therapeutic Approaches

Olivia Swain et al.

Summary: COVID-19 pandemic has led to neurologic complications, with the presence of coronaviruses in the CNS. Mitochondria and mTOR signaling pathways play critical roles in antiviral immune response, and potentially impact endocytic processes. The mechanisms behind severe neurologic complications and potential treatments with approved drugs targeting mitochondria and mTOR pathways are still largely unknown.

JOURNAL OF NEUROSCIENCE (2021)

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Article Medicine, General & Internal

Thromboembolic Risk in Hospitalized and Nonhospitalized COVID-19 Patients: A Self-Controlled Case Series Analysis of a Nationwide Cohort

Frederick K. Ho et al.

Summary: Confirmed COVID-19 infection was associated with early elevations in risk of MI and ischemic stroke, and substantially stronger and prolonged elevations in risk of DVT and PE, both in hospital and community settings. Thromboembolism, especially PE, should be considered among people with COVID-19 in the community.

MAYO CLINIC PROCEEDINGS (2021)

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Review Cell Biology

COVID-19 and Acute Coronary Syndromes: From Pathophysiology to Clinical Perspectives

Luca Esposito et al.

Summary: COVID-19 patients with ACS may experience oxygen supply/demand imbalance, direct viral cellular damage, systemic inflammatory response, microvascular thrombosis, and endothelial dysfunction. COVID-19 can induce both type 1 and type 2 MI and promote a prothrombotic state. Managing patients with COVID-19 and ACS is challenging, and a deeper understanding of ACS pathophysiology may provide new research insights and treatment perspectives.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Cell Biology

Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria

V. Otasevic et al.

Summary: Ferroptosis is a newly described form of regulated cell death characterized by iron accumulation and lipid peroxidation due to impaired antioxidant defense. Mitochondria play a significant role in the induction and execution of ferroptosis, especially in different pathological states like cancer, cardiovascular diseases, and neurodegenerative diseases. The review emphasizes the need for further research on the relationship between ferroptosis and mitochondria in various pathologies, and highlights potential strategies for future therapeutic development.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism

Jing Du et al.

Summary: The combination of dihydroartemisinin (DHA) and cisplatin (DDP) synergistically enhances the cytotoxicity of pancreatic ductal adenocarcinoma (PDAC) cells by inducing ferroptosis. The impairment of mitochondrial homeostasis and the accumulation of free iron and lipid peroxidation contribute to the cytotoxic effects. Pharmacological manipulation of iron levels can modulate the sensitivity of PDAC cells to DHA/DDP-induced ferroptosis. These findings suggest a promising therapeutic strategy for PDAC treatment.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

CISD3 inhibition drives cystine-deprivation induced ferroptosis

Yanchun Li et al.

Summary: CISD3 plays a crucial regulatory role in cancer progression and ferroptosis, with its overexpression associated with poorer survival rates, while its depletion accelerates ferroptotic cell death. Depletion of CISD3 leads to metabolic reprogramming towards glutaminolysis, which is essential for mitochondrial oxidative phosphorylation.

CELL DEATH & DISEASE (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

Desiree Bartolini et al.

Summary: This study found that SARS-CoV2 infection impairs cellular glutathione metabolism, leading to a decrease in GSH levels. Treatment with NAC and the antiviral drug Nel can prevent this defect.

REDOX BIOLOGY (2021)

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Review Medicine, General & Internal

Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19

Jose J. Valdes-Aguayo et al.

Summary: Mitochondria play a crucial role in regulating inflammation, particularly during COVID-19 infection. The virus utilizes mitochondria for viral genome replication and maintenance, leading to exacerbation and spread of inflammation. Mitochondrial damage may enhance immune activation, worsening pro-inflammatory status.

MEDICINA-LITHUANIA (2021)

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Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Medicine, Research & Experimental

Ferroptosis as a novel therapeutic target for cardiovascular disease

Xiaoguang Wu et al.

Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.

THERANOSTICS (2021)

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Article Multidisciplinary Sciences

Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

Yuling Han et al.

Summary: Researchers have developed lung and colonic organoid models using human pluripotent stem cells, which demonstrate susceptibility to SARS-CoV-2 infection. These models are valuable for studying the infection of the virus and screening drugs, with potential therapeutic implications for COVID-19.

NATURE (2021)

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Article Biochemical Research Methods

Metabolic Perturbation Associated With COVID-19 Disease Severity and SARS-CoV-2 Replication

Shuba Krishnan et al.

Summary: This study used patient-derived data and in vitro experiments to investigate the relationship between metabolic pathways and the replication of the SARS-CoV-2 virus, finding that severe disease is characterized by increased plasma glucose levels. Immune phenotype analysis revealed altered expression patterns, and glycolysis and glutaminolysis were identified as essential for virus replication.

MOLECULAR & CELLULAR PROTEOMICS (2021)

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Review Physiology

SARS CoV-2 related microvascular damage and symptoms during and after COVID-19: Consequences of capillary transit-time changes, tissue hypoxia and inflammation

Leif Ostergaard

Summary: COVID-19 infection can cause symptoms in multiple organs, including low blood oxygen levels, muscle pain, fatigue, and mood changes. Capillary damage and inflammation may play a role in these symptoms.

PHYSIOLOGICAL REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis

Fei Han et al.

Summary: IL-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species (ROS)-dependent lipid peroxidation and disrupting iron homeostasis. Treatment with Ferrostatin-1 (Fer-1) and antioxidant NAC partially reverses the effects of IL-6 on lipid peroxidation and ferroptosis.

BIOENGINEERED (2021)

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Review Cell Biology

Mitochondria regulation in ferroptosis

Hai Wang et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

Wenyuan Li et al.

DNA AND CELL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex

Xi Chen et al.

FEBS JOURNAL (2020)

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Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Biology

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

Xintian Xu et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

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Editorial Material Cardiac & Cardiovascular Systems

COVID-19, Arrhythmic Risk, and Inflammation Mind the Gap!

Pietro Enea Lazzerini et al.

CIRCULATION (2020)

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Article Medical Laboratory Technology

Prominent changes in blood coagulation of patients with SARS-CoV-2 infection

Huan Han et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

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Review Cardiac & Cardiovascular Systems

COVID-19 and Multiorgan Response

Sevim Zaim et al.

CURRENT PROBLEMS IN CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic

Alaide Chieffo et al.

EUROPEAN HEART JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Myocardial localization of coronavirus in COVID-19 cardiogenic shock

Guido Tavazzi et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

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Article Cardiac & Cardiovascular Systems

Recognizing COVID-19-related myocarditis: the possible pathophysiology and proposed guideline for diagnosis and management

Bhurint Siripanthong et al.

HEART RHYTHM (2020)

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Article Critical Care Medicine

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

Xiaobo Yang et al.

Lancet Respiratory Medicine (2020)

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Article Medicine, General & Internal

Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State

Eli S. Rosenberg et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Biochemistry & Molecular Biology

Identification of Frataxin as a regulator of ferroptosis

Jing Du et al.

REDOX BIOLOGY (2020)

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Clinical and immunological features of severe and moderate coronavirus disease 2019

Guang Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing

Nicholas J. Bessman et al.

SCIENCE (2020)

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Article Virology

Upregulation of miR-101 during Influenza A Virus Infection Abrogates Viral Life Cycle by Targeting mTOR Pathway

Shipra Sharma et al.

VIRUSES-BASEL (2020)

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Article Multidisciplinary Sciences

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Xiuyuan Ou et al.

NATURE COMMUNICATIONS (2020)

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Review Cardiac & Cardiovascular Systems

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic

Elissa Driggin et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Medicine, General & Internal

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

Tao Chen et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Letter Medicine, General & Internal

Acute limb ischaemia in two young, non-atherosclerotic patients with COVID-19

Paolo Perini et al.

LANCET (2020)

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Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

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Editorial Material Pharmacology & Pharmacy

An Open Question: Is It Rational to Inhibit the mTor-Dependent Pathway as COVID-19 Therapy?

Giuseppe Terrazzano et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Oncology

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Zou Xin et al.

FRONTIERS OF MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

Tao Guo et al.

JAMA CARDIOLOGY (2020)

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Article Multidisciplinary Sciences

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

Denisa Bojkova et al.

NATURE (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

Tao Bai et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Letter Hematology

Abnormal concentration of porphyrins in serum from COVID-19 patients

Itxaso San Juan et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science

Paul C. Evans et al.

CARDIOVASCULAR RESEARCH (2020)

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Letter Immunology

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

He-wei Jiang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Infectious Diseases

Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

Marvin Edeas et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Cardiac & Cardiovascular Systems

Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases

Diana Lindner et al.

JAMA CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)

Valentina O. Puntmann et al.

JAMA CARDIOLOGY (2020)

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Article Virology

Coagulation disorders in coronavirus infected patients: COVID-19, SARS- CoV-1, MERS-CoV and lessons from the past

Dimitrios Giannis et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

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Editorial Material Medicine, General & Internal

COVID-19 acute respiratory distress syndrome (ARDS): clinical features and differences from typical pre-COVID-19ARDS

Peter G. Gibson et al.

MEDICAL JOURNAL OF AUSTRALIA (2020)

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Article Biochemistry & Molecular Biology

The protein expression profile of ACE2 in human tissues

Feria Hikmet et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Extrapulmonary manifestations of COVID-19

Aakriti Gupta et al.

NATURE MEDICINE (2020)

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Article Immunology

Therapeutic blockade of inflammation in severe COVID-19 infection with intravenous N-acetylcysteine

Homam Ibrahim et al.

CLINICAL IMMUNOLOGY (2020)

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Review Public, Environmental & Occupational Health

Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis

Petek Eylul Taneri et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2020)

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Letter Medicine, General & Internal

Regional differences in hospital admissions for ST-elevation and non-ST-elevation myocardial infarctions during the Coronavirus disease-19 (COVID-19) pandemic in Austria

Daniel Kiblboeck et al.

WIENER KLINISCHE WOCHENSCHRIFT (2020)

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Article Allergy

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

Ana Copaescu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Health Care Sciences & Services

Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: a Systematic Review and Meta-analysis

Arunmozhimaran Elavarasi et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2020)

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Article Medicine, General & Internal

Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19 A case report

Yan Liu et al.

MEDICINE (2020)

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Review Pharmacology & Pharmacy

Can Activation of NRF2 Be a Strategy COVID-19?

Antonio Cuadrado et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Nox2 activation in Covid-19

Francesco Violi et al.

REDOX BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

Natalia de las Heras et al.

ANTIOXIDANTS (2020)

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Article Biochemistry & Molecular Biology

Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore

Richard Gordan et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

Glutathione Supplementation as an Adjunctive Therapy in COVID-19

Vika Guloyan et al.

ANTIOXIDANTS (2020)

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Article Cardiac & Cardiovascular Systems

Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID-19): autopsy reveals a ferroptosis signature

Werner Jacobs et al.

ESC HEART FAILURE (2020)

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Article Cardiac & Cardiovascular Systems

Incidence of myocardial injury in coronavirus disease 2019 (COVID-19): a pooled analysis of 7,679 patients from 53 studies

Zhi-Chun Gu et al.

CARDIOVASCULAR DIAGNOSIS AND THERAPY (2020)

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Article Pharmacology & Pharmacy

Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms

Clotilde Laussel et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury

Ning Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Medicine, Research & Experimental

Increased Serum Levels of Hepcidin and Ferritin Are Associated with Severity of COVID-19

Cuixing Zhou et al.

MEDICAL SCIENCE MONITOR (2020)

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Letter Critical Care Medicine

Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia

Lijuan Hu et al.

CRITICAL CARE (2020)

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Article Microbiology

Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival

Wei Liu et al.

CURRENT CLINICAL MICROBIOLOGY REPORTS (2020)

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Article Cardiac & Cardiovascular Systems

EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic

Alaide Chieffo et al.

EUROPEAN HEART JOURNAL (2020)

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Review Health Care Sciences & Services

N-Acetylcysteine to Combat COVID-19: An Evidence Review

Zhongcheng Shi et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2020)

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Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention

Aikaterini Nasi et al.

TOXICOLOGY REPORTS (2020)

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Article Biochemistry & Molecular Biology

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

Jing Du et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Multidisciplinary Sciences

Ferroptosis as a target for protection against cardiomyopathy

Xuexian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Cell Biology

Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages

Xiaorong Hu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Medicine, Research & Experimental

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Wenjun Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Biochemistry & Molecular Biology

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

Xiaoqing Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

Naroa Kajarabille et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

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Article Biochemistry & Molecular Biology

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

Yansheng Feng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Immunology

Severe Acute Respiratory Syndrome Historical, Epidemiologic, and Clinical Features

David S. C. Hui et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2019)

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Article Biochemistry & Molecular Biology

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

Bei Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Oncology

Cell growth potential drives ferroptosis susceptibility in rhabdomyosarcoma and myoblast cell lines

Silvia Codenotti et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

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Article Medicine, General & Internal

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection

Jeffrey C. Kwong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study

Yue Chen et al.

SCIENTIFIC REPORTS (2018)

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Review Medicine, General & Internal

Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease

Raed Daher et al.

PRESSE MEDICALE (2017)

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Article Oncology

Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

Ryosuke Shintoku et al.

CANCER SCIENCE (2017)

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Review Biochemistry & Molecular Biology

Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy

Gladys O. Latunde-Dada

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

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Serum Ferritin Relates to Carotid Intima-Media Thickness in Offspring of Fathers With Higher Serum Ferritin Levels

Anna Prats-Puig et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

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Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

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Ferroptosis is an autophagic cell death process

Minghui Gao et al.

CELL RESEARCH (2016)

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The association between influenza infection, vaccination, and atrial fibrillation: A nationwide case-control study

Ting-Yung Chang et al.

HEART RHYTHM (2016)

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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

Wenjing Xu et al.

CELL REPORTS (2015)

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Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

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Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Rachid Skouta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

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Article Biochemistry & Molecular Biology

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

Douglas B. Kell et al.

METALLOMICS (2014)

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Synchronized renal tubular cell death involves ferroptosis

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Immunology

Tetraspanins in extracellular vesicle formation and function

Zoraida Andreu et al.

FRONTIERS IN IMMUNOLOGY (2014)

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A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors

Luis E. Raez et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice

Markus Wortmann et al.

CIRCULATION RESEARCH (2013)

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Article Hematology

Ferritin Is Independently Associated With the Presence of Coronary Artery Calcium in 12033 Men

Ki-Chul Sung et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

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Review Biochemistry & Molecular Biology

Signaling Organelles of the Innate Immune System

Jonathan C. Kagan

CELL (2012)

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mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

Marina Bayeva et al.

CELL METABOLISM (2012)

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Into the Eye of the Cytokine Storm

Jennifer R. Tisoncik et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2012)

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The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis

Ethan Will Taylor

TOXICOLOGY (2010)

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Article Cardiac & Cardiovascular Systems

Oxidative Stress-Induced Afterdepolarizations and Calmodulin Kinase II Signaling

Lai-Hua Xie et al.

CIRCULATION RESEARCH (2009)

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Prevalence and Significance of Coagulation Abnormalities in Community-Acquired Pneumonia

Eric B. Milbrandt et al.

MOLECULAR MEDICINE (2009)

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Review Medicine, General & Internal

Medical Progress: Myocarditis.

Leslie T. Cooper

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Article Medicine, Research & Experimental

Overexpression of transferrin receptor and ferritin related to clinical symptoms and destabilization of human carotid plaques

Wei Li et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2008)

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Review Microbiology

Viral infection and iron metabolism

Hal Drakesmith et al.

NATURE REVIEWS MICROBIOLOGY (2008)

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Review Biochemistry & Molecular Biology

Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?

Jyoti D. Malhotra et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

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Review Cell Biology

Virus factories: associations of cell organelles for viral replication and morphogenesis

RR Novoa et al.

BIOLOGY OF THE CELL (2005)

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Article Immunology

Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3

I Theurl et al.

JOURNAL OF INFECTIOUS DISEASES (2004)

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Article Virology

The effect of iron overload on in vitro HIV-1 infection

HN Traoré et al.

JOURNAL OF CLINICAL VIROLOGY (2004)

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Article Medicine, Research & Experimental

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

E Nemeth et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

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Article Biochemistry & Molecular Biology

Molecular basis of vitamin E action - Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration

S Khanna et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state

AA Starkov et al.

JOURNAL OF NEUROCHEMISTRY (2003)

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Article Hematology

Virchow's triad revisited: Blood constituents

I Chung et al.

PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS (2003)

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