☆ 4.6 Review

Recent updates in nanotechnological advances for wound healing: A narrative review

NANOTECHNOLOGY REVIEWS (2023)

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Article Biochemistry & Molecular Biology

Carboxymethyl chitosan/sodium alginate hydrogels with polydopamine coatings as promising dressings for eliminating biofilm and multidrug-resistant bacteria induced wound healing

Tao Liu et al.

Summary: A mussel-inspired multifunctional hydrogel (CAC/PDA/Cu(H2O2)) was prepared, which exhibited antibacterial, anti-inflammatory, and angiogenesis-promoting properties, accelerating wound healing. The hydrogel showed excellent therapeutic effects in Methicillin-resistant Staphylococcus aureus (MRSA) induced-rat infection models, efficiently eliminating MRSA, significantly reducing inflammatory expression, promoting angiogenesis, and ultimately shortening the wound healing time.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Biochemistry & Molecular Biology

Controlled release of protein from gelatin/chitosan hydrogel containing platelet-rich fibrin encapsulated in chitosan nanoparticles for accelerated wound healing in an animal model

Fatemeh Mirjalili et al.

Summary: In this study, platelet-rich fibrin-chitosan (CH-PRF) nanoparticles were loaded into gelatin-chitosan hydrogel (Gel-CH/CH-PRF) to create a hydrogel dressing for wound healing. The Gel-CH/CH-PRF hydrogel exhibited excellent swelling behavior, good porosity, high absorption of wound exudates, and proper vapor permeability rate. It also demonstrated sustained release of proteins and strong antimicrobial activity. In vivo experiments showed that the Gel-CH/CH-PRF hydrogel promoted wound closure, increased epidermis thickness, and enhanced the formation of new granulation tissue. These findings highlight the potential of Gel-CH/CH-PRF hydrogel as an effective wound dressing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Materials Science, Multidisciplinary

Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing

Yanan Zhao et al.

Summary: This study constructed a nanofiber material with antibacterial and pro-angiogenic effects, which can accelerate wound healing and reduce the occurrence of infection by adding nanosilvers and black phosphorus.

MATERIALS & DESIGN (2023)

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Article Materials Science, Multidisciplinary

Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healing

Wen Luo et al.

Summary: In this study, a stable and highly effective antibacterial and anti-inflammatory Ag-Titanium-oxo-cluster (Ag-TOC, Ag9Ti4) was developed through one-step solvothermal method by introducing silver and salicylic acid. The Ag9Ti4 cluster was incorporated into a dopamine-containing hydrogel system, which exhibited excellent antibacterial and photothermal properties in vitro. Furthermore, the Ag9Ti4 hydrogel system demonstrated superior anti-inflammatory and wound healing ability under NIR condition in vivo. The construction of the antibacterial, photothermal, and stable Ag-TOC hydrogel system provides a new strategy for expanding the biomedical applications of TOCs.

MATERIALS & DESIGN (2023)

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Article Chemistry, Physical

A hydrogel system containing molybdenum-based nanomaterials for wound healing

Yongzhou Lu et al.

Summary: Delayed or non-healing wounds have a significant impact on patients' quality of life and pose a financial burden on public health systems worldwide. A hydrogel containing low-valence-state molybdenum nanomaterials has been developed to scavenge reactive oxygen species (ROS) and promote wound healing. In vitro and in vivo studies have shown that this novel Mo hydrogel accelerates wound healing, stimulates angiogenesis, and enhances growth factor expression. Due to the essentiality of molybdenum in all organisms, this Mo hydrogel holds great potential for clinical translation in wound healing applications.

NANO RESEARCH (2023)

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Article Chemistry, Multidisciplinary

An antioxidant and antibacterial polydopamine-modified thermo-sensitive hydrogel dressing for Staphylococcus aureus-infected wound healing

Pengjin Ge et al.

Summary: In this study, a thermo-sensitive and ROS-scavenging hydrogel based on polydopamine modified poly(epsilon-caprolactone-co-glycolide)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone-co-glycolide) (PDA/P2) triblock copolymer was developed. The hydrogel showed good ROS-scavenging ability and antibacterial activity against E. coli and S. aureus. In vivo experiments demonstrated that the hydrogel dressing promoted wound healing by inhibiting bacterial growth, alleviating inflammation, and inducing angiogenesis and collagen deposition.

NANOSCALE (2023)

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Article Multidisciplinary Sciences

Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

Vida Shadman-Manesh et al.

Summary: A PCL-PEG-EYO scaffold was developed for burn healing, which showed great potential in cell viability, proliferation, and attachment, as well as antibacterial activity. In vivo experiments demonstrated a statistically significant enhancement in wound closure, re-epithelialization, angiogenesis, and collagen synthesis using the scaffold.

SCIENTIFIC REPORTS (2023)

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Article Materials Science, Biomaterials

An antibacterial and proangiogenic double-layer drug-loaded microneedle patch for accelerating diabetic wound healing

Shan Gao et al.

Summary: Researchers have developed a double-layer drug-loaded microneedle patch with antibacterial and angiogenesis-promoting properties, which can accelerate the healing of diabetic wounds.

BIOMATERIALS SCIENCE (2023)

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Article Infectious Diseases

In Vitro Antibacterial and Wound Healing Activities Evoked by Silver Nanoparticles Synthesized through Probiotic Bacteria

Gayathri Vijayakumar et al.

Summary: In this study, probiotic bacteria were used to synthesize silver nanoparticles with significant antioxidant and antibacterial activities. The biosynthesized AgNPs showed significant wound-healing capabilities, as observed through an in vitro scratch-wound assay. Cytotoxic experiments demonstrated that the biosynthesized AgNPs were not extremely hazardous to fibroblast cells.

ANTIBIOTICS-BASEL (2023)

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Article Materials Science, Multidisciplinary

Implantable Electrospun Nanofibers with Wound-Healing Capabilities in the Reduction of Pressure Ulcers

Rim Bouhajeb et al.

Summary: We have developed an implantable dressing material made of electrospun poly(lactic acid) nanofibers containing the hydroethanolic extract of T. ramosissimum. The material showed improved wound-healing capabilities, reduced injury area, and high wound closure percentage in in vivo experiments on mice. The chemical structures of the main released compounds were identified using nuclear magnetic resonance.

ACS APPLIED POLYMER MATERIALS (2023)

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Article Nanoscience & Nanotechnology

Cross-Linked Electrospun pH-Sensitive Nanofibers Adsorbed with Temporin-Ra for Promoting Wound Healing

Fatemeh Koohzad et al.

Summary: Bioresponsive nanodrug delivery systems using poly-anionic and poly-cationic biopolymers have been developed for tissue engineering applications. These systems have exhibited pH-sensitive drug release properties and are capable of meeting the requirements for ideal wound dressing. In vitro and in vivo studies have shown that the synthesized nanofiber scaffold enhances wound healing by promoting cell adhesion, proliferation, migration, and tissue repair.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Engineering, Biomedical

Novel polycaprolactone (PCL)-type I collagen core-shell electrospun nanofibers for wound healing applications

Javier Mauricio Anaya Mancipe et al.

Summary: In this study, a coaxial electrospinning process was proposed to fabricate core-shell nanofiber mats of Col_1/PVA. This strategy preserved the structure of collagen and simplified the manufacturing process. The resulting nanostructured mats showed good biocompatibility, liquid absorption, and structural stability, making them a potential dressing for skin damage regeneration.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2023)

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Article Engineering, Biomedical

Multifunctional MOF-Based Microneedle Patch With Synergistic Chemo-Photodynamic Antibacterial Effect and Sustained Release of Growth Factor for Chronic Wound Healing

Yongnian Zeng et al.

Summary: Researchers have developed a multifunctional microneedle (MN) patch that achieves rapid wound healing through efficient chemo-photodynamic antibacterial effects and sustained release of growth factors. The MN patch contains low-dose antibiotics and metal-organic frameworks (MOFs) encapsulating bioactive small molecules. When the MN patch penetrates the skin, the drugs and bioactive substances are rapidly released to the wound. Under light irradiation, MOF-based nanoparticles convert O-2 into O-1(2), synergistically removing pathogenic bacteria from the wound. The nanoparticles also continuously release growth factors, promoting the formation of epithelial tissue and neovascularization to accelerate chronic wound healing.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Chemistry, Multidisciplinary

All-Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Ya-Jun Fu et al.

Summary: Macrophages in diabetic wounds can be divided into pro-inflammatory M1 and anti-inflammatory M2 types. Hydrogel dressings with the ability to regulate macrophage heterogeneity show potential in promoting diabetic wound healing. An all-natural hydrogel has been developed, which can convert M1 macrophages into M2 macrophages without additional ingredients or external intervention, providing a simple and safe approach for accelerating wound healing.

ADVANCED SCIENCE (2023)

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Article Engineering, Biomedical

Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing

Nan Hu et al.

Summary: Adipose-derived stem cell (ADSC)-originating exosomes (ADSC-Exos) have potential in diabetic wound repair, but their disadvantages limit their clinical application. This study developed hypoxia-pretreated ADSC-Exo (ADSC-HExo)-embedded GelMA hydrogels (GelMA-HExo) and demonstrated their therapeutic effects in promoting diabetic wound healing. These findings suggest a new therapeutic strategy for diabetic ulcers.

ACTA BIOMATERIALIA (2023)

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Review Pharmacology & Pharmacy

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

Marcel Henrique Marcondes Sari et al.

Summary: Wounds are alterations in skin integrity resulting from any type of trauma. Therapeutic approaches for wound healing include dressings and topical pharmacological agents. Soft nanoparticles-based hydrogels emerge as promising alternatives to accelerate the healing process. Soft nanoparticles improve the performance of bioactive compounds in hydrogels for wound healing.

PHARMACEUTICS (2023)

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Review Pharmacology & Pharmacy

Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing

Tengfei Liu et al.

Summary: Various factors can cause damage to the skin, leading to wounds. Nonhealing or chronic wounds have a severe impact on patients' well-being and impose heavy burdens on society. The use of nanomaterials has shown promise in promoting wound healing due to their unique physicochemical characteristics at the nanoscale. This review provides an overview of wound categories, the wound healing process, and critical influencing factors, and discusses the applications of nanomaterials with intrinsic therapeutic effects and nanomaterials-based drug delivery systems in promoting wound healing. Limitations and future perspectives of nanomaterials in wound healing are also discussed.

ADVANCED DRUG DELIVERY REVIEWS (2023)

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Article Engineering, Biomedical

Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

Pei Wang et al.

Summary: Diabetes mellitus leads to delayed wound healing, inflammation, decreased angiogenesis, and increased reactive oxygen species. A microneedle patch made of PLGA and loaded with MgH2 is developed to address diabetic wounds. The patch delivers MgH2 transdermally, which reacts with body fluids to release hydrogen and magnesium ions. The released hydrogen reduces reactive oxygen species, transforming the pathological microenvironment, while the magnesium ions promote the polarization of pro-healing M2 macrophages. This intelligent microneedle patch provides a novel approach for accelerating wound healing through local and sustainable preservation and release of H2 and Mg2+.

BIOACTIVE MATERIALS (2023)

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Article Biophysics

Silver nanoparticles modified hFGF2-linking camelina oil bodies accelerate infected wound healing

Hongxiang Liu et al.

Summary: Silver nanoparticles modified camelina oil bodies with human fibroblast growth factor 2 were designed for the treatment of bacterial infection wounds. The results showed that this material had both antibacterial and wound healing effects, with good biocompatibility. Therefore, it has potential for application in the repair of bacterial infection wounds.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Article Polymer Science

In Vitro and In Silico Characterization of Curcumin-Loaded Chitosan-PVA Hydrogels: Antimicrobial and Potential Wound Healing Activity

Hitesh Chopra et al.

Summary: Curcumin-based hydrogel system with antimicrobial activity and wound healing potential was developed and evaluated in vitro and in silico. The hydrogel showed antimicrobial activity against both gram-positive and gram-negative microorganisms. In silico studies revealed good binding energy scores and significant interaction of curcumin components with key residues of inflammatory proteins, indicating its potential for wound healing. Further in vivo experiments are needed to assess the clinical efficacy of the hydrogel films.

GELS (2023)

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Article Biochemistry & Molecular Biology

Biocompatible Triple-Helical Recombinant Collagen Dressings for Accelerated Wound Healing in Microneedle-Injured and Photodamaged Skin

Caihong Fu et al.

Summary: We developed biocompatible and nonirritating triple-helical recombinant collagen (THRC) dressings for accelerated healing of microneedle-injured and photodamaged acute skin wounds. The THRC dressings exhibited superior biocompatibility and bioactivity, significantly promoting the proliferation and adhesion of fibroblasts. In vivo studies demonstrated that the THRC dressings effectively healed damaged dermis and accelerated re-epithelialization and collagen deposition.

COSMETICS (2023)

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Review Chemistry, Applied

Cyclodextrin regulated natural polysaccharide hydrogels for biomedical applications-a review

Shuoxuan Wang et al.

Summary: Cyclodextrin and its derivative (CDs) are natural building blocks for functional biomaterials. Natural polysaccharide hydrogels (NPHs) are widely used in biomedical applications, and CD regulated NPHs (CD-NPHs) improve their mechanical qualities and gelation times. However, there is still no comprehensive review on CD-NPHs regarding their construction, classification, and application in biomedical fields. This article provides a systematic overview of CD-NPHs classification and their role in biomedical fields, and discusses the current challenges and prospects, aiming to facilitate the development of CD-NPHs-based biomedicine.

CARBOHYDRATE POLYMERS (2023)

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Article Chemistry, Applied

Physical dual-network photothermal antibacterial multifunctional hydrogel adhesive for wound healing of drug-resistant bacterial infections synthesized from natural polysaccharides

Xuan Yue et al.

Summary: A physical dual-network multifunctional hydrogel adhesive based on polysaccharide material was designed for the treatment of full-thickness skin defects infected with multidrug-resistant bacteria. The hydrogel exhibited good biocompatibility and wound-healing ability, along with rapid self-healing, injectability, shape-adaptation, NIR/pH responsiveness, high tissue-adhesion, and mechanical properties. Furthermore, the hydrogel demonstrated antioxidant, hemostatic, photothermal-antibacterial, and wound-healing effects.

CARBOHYDRATE POLYMERS (2023)

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Letter Surgery

Recent advances in the treatment of biofilms induced surgical site infections

Hitesh Chopra et al.

INTERNATIONAL JOURNAL OF SURGERY (2023)

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Article Polymer Science

Design and Evaluation of Solid Lipid Nanoparticles Loaded Topical Gels: Repurpose of Fluoxetine in Diabetic Wound Healing

Farhat Fatima et al.

Summary: This study aimed to develop a topical gel containing solid lipid nanoparticles (SLNs) encapsulating fluoxetine for diabetic wound healing. The optimized SLN showed desirable particle size, polydispersity, and encapsulation efficiency. In vitro release studies demonstrated sustained drug delivery. The SLN-loaded gel also exhibited promising effects in an in vivo study using diabetic rats. Overall, the SLN gel could be a potential carrier for the treatment of diabetic wounds.

GELS (2023)

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Article Materials Science, Textiles

A facile design of EGF conjugated PLA/gelatin electrospun nanofibers for nursing care of in vivo wound healing applications

Fei Xu et al.

Summary: Nano/microfiber structures made from biodegradable polymers, such as poly(lactic acid) (PLA)/gelatin (GEL) conjugated with epidermal growth factor (EGF), show potential for biomedical applications, particularly in diabetic wound healing. This study evaluated the properties of PLA/GEL nanofiber scaffolds conjugated with EGF, including their morphological, mechanical, antibacterial, and wound healing activities. The results demonstrated that the nanofiber PLA/GEL conjugated with EGF exhibited superior properties and could be a promising material for nursing care of wound healing.

JOURNAL OF INDUSTRIAL TEXTILES (2022)

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Review Pharmacology & Pharmacy

Fast Dissolution Electrospun Medicated Nanofibers for Effective Delivery of Poorly Water-Soluble Drug

Yrysbaeva Aidana et al.

Summary: Electrospinning is an industrial process that can be used to produce electrospun medicated nanofibers for fast-dissolving oral drug delivery systems. It requires the selection of appropriate polymer matrices and drug carriers, as well as addressing issues such as scalable production and solid dosage form conversion.

CURRENT DRUG DELIVERY (2022)

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Article Food Science & Technology

Functionalization of electrospun fish gelatin mats with bioactive agents: Comparative effect on morphology, thermo-mechanical, antioxidant, antimicrobial properties, and bread shelf stability

Kaiser Mahmood et al.

Summary: In this study, fish gelatin-based nanofiber mats embedded with different bioactive agents via electrospinning showed changes in their properties such as antioxidant, antimicrobial abilities and bread packaging properties. While the addition of BAs resulted in lower tensile strength and elongation at break, it improved radical scavenging and antibacterial activity. The mats retained a certain amount of bioactive agents during long-term storage.

FOOD SCIENCE & NUTRITION (2022)

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Article Engineering, Environmental

An M2 macrophage-polarized anti-inflammatory hydrogel combined with mild heat stimulation for regulating chronic inflammation and impaired angiogenesis of diabetic wounds

Yang Yuan et al.

Summary: An M2 macrophage-polarized anti-inflammatory hydrogel combined with mild heat stimulation is designed for the treatment of diabetic foot ulcers (DFUs). The hydrogel promotes angiogenesis and skin regeneration, resulting in shortened healing time of DFUs.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Environmental

Precise Engineering of Lignin Incorporated Dextran/Glycol Nanomaterials for Wound Dressings for the Care of Anorectal Surgery

Miao Dai et al.

Summary: The researchers developed Lignin-loaded dextran/glycol nanoparticles and investigated their application in wound healing; the experimental results demonstrated that this nanomaterial can promote wound healing and possess antibacterial activity, making it a potential novel dressing material.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2022)

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Review Pharmacology & Pharmacy

A Comprehensive Review on Hydrogels

Hitesh Chopra et al.

Summary: Hydrogels, with their tunable properties and optimized therapeutic benefits, have emerged as a solution to the issues of traditional drug delivery systems. They find applications in wound healing, ocular systems, vaginal gels, and tissue and bone engineering, among others.

CURRENT DRUG DELIVERY (2022)

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Article Chemistry, Multidisciplinary

Polydopamine Decorated Microneedles with Fe-MSC-Derived Nanovesicles Encapsulation for Wound Healing

Wenjuan Ma et al.

Summary: This study presents a novel wound dressing that combines antioxidation, antiinflammation, and efficient angiogenesis induction capacities, and demonstrates its excellent effect on diabetic wound healing in vivo.

ADVANCED SCIENCE (2022)

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Review Endocrinology & Metabolism

Advancement in Nanoformulations for the Management of Diabetic Wound Healing

Shailendra Singh Bhadauria et al.

Summary: This article discusses the role of nanoformulations in the treatment of diabetic wound healing, emphasizing the importance of nanotechnology in this field. It highlights the need for healthcare workers, pharmaceutical professionals, and researchers to pay more attention to the application of nanoformulations in the wound healing of diabetic patients.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2022)

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Article Biotechnology & Applied Microbiology

Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

Mitra Bagheri et al.

Summary: The study developed chitosan/polyethylene oxide nanofibers embedded with antibacterial silver and zinc oxide nanoparticles, showing high antioxidant and antibacterial activity against common hospital-acquired infections. The optimal concentrations of ZnONPs and AgNPs were determined to have no cytotoxic effects on fibroblast cells, while also exhibiting good blood compatibility and promoting fibroblast migration and proliferation at wound sites. The nanofibrous mats demonstrated potential as effective wound dressings.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

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Article Engineering, Biomedical

Peptide-based nanomaterials: Self-assembly, properties and applications

Tong Li et al.

Summary: Peptide-based self-assembly nanomaterials, with diverse structures and functionalities, play a significant role in bioapplications. This review provides an overview of the recent advances in peptide-based self-assembly nanostructures, focusing on the driving forces and assembly mechanisms. It also summarizes the synthesis, properties, and applications of functional peptide nanomaterials. The challenges and future prospects of peptide-based nanomaterials are discussed.

BIOACTIVE MATERIALS (2022)

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Letter Surgery

Wound dressings: Recent updates

Hitesh Chopra et al.

INTERNATIONAL JOURNAL OF SURGERY (2022)

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Article Engineering, Environmental

Three-dimensional layered nanofiber sponge with in situ grown silver-metal organic framework for enhancing wound healing

Jiatian Chen et al.

Summary: In this study, a three-dimensional layered nanofiber sponge was successfully prepared, which achieved timely absorption of exudate, accelerated hemostasis, and inhibited bacterial growth and inflammation by incorporating silver-metal organic framework and curcumin. The sponge showed excellent hemostasis and coagulation effect, as well as remarkable antibacterial effect and good cytocompatibility. In vivo experiments confirmed its high wound healing efficiency.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Silver Nanoparticles Biocomposite Films with Antimicrobial Activity: In Vitro and In Vivo Tests

Anca Niculina Cadinoiu et al.

Summary: The aim of this study was to develop a biocomposite film based on chitosan, poly (vinyl alcohol), and silver nanoparticles with antimicrobial properties. The film was characterized from a structural and morphological point of view and was found to be biocompatible and have antimicrobial activity through in vitro and in vivo tests.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Chemistry, Medicinal

Nanotechnology-Based Dressings for Wound Management

Janaina A. Ataide et al.

Summary: Wound healing is a complex and crucial process, especially for patients with chronic wounds. Wound dressings based on nanotechnology systems have emerged as an effective option to improve healing by releasing growth factors and bioactive agents, providing opportunities for new wound treatment developments.

PHARMACEUTICALS (2022)

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Article Materials Science, Biomaterials

Rational design of flexible microneedles coupled with CaO2@PDA-loaded nanofiber films for skin wound healing on diabetic rats

Zhiyong Zeng et al.

Summary: In this study, a synergistically flexible microneedle dressing loaded with metformin and CaO2@PDA nanoparticles was developed for promoting diabetic wound healing. The microneedles effectively penetrated the diabetic rat skin, triggering a response to regulate blood glucose levels. The microneedle dressings also exhibited anti-inflammatory, oxygen supply, and exudate absorption properties. The results demonstrated that this microneedle system could serve as a promising approach for efficient wound healing in diabetic patients.

BIOMATERIALS SCIENCE (2022)

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Article Polymer Science

Design and Development of Neomycin Sulfate Gel Loaded with Solid Lipid Nanoparticles for Buccal Mucosal Wound Healing

Khaled M. Hosny et al.

Summary: This study developed a gel containing neomycin sulfate loaded in solid lipid nanoparticles for buccal mucosal wound healing, with enhanced antimicrobial activity. The optimized formulation showed good mechanical and rheological properties, regulated drug release, and increased permeability and antibacterial activity.

GELS (2022)

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Review Environmental Sciences

Nanomaterials: types, properties, recent advances, and toxicity concerns

Muhammad Sajid

Summary: Nanomaterials have unique physical and chemical properties compared to bulk materials, leading to exciting applications in science and technology. This review summarizes the classification, synthesis methods, and properties of nanomaterials, including newly developed ones. It also provides a brief overview of the environmental health and safety considerations associated with nanomaterials.

CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH (2022)

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Article Polymer Science

Preparation and Evaluation of Chitosan/PVA Based Hydrogel Films Loaded with Honey for Wound Healing Application

Hitesh Chopra et al.

Summary: In this study, chitosan/polyvinyl alcohol (PVA)-based hydrogel films loaded with honey were developed for potential wound healing applications. The films were evaluated for their physical and mechanical properties, as well as their antimicrobial performance against Staphylococcus aureus. The results demonstrated the potential of these films as wound dressings and suggested the need for further in vivo experiments to evaluate their clinical efficacy.

GELS (2022)

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Article Materials Science, Biomaterials

Preparation of antibacterial electrospun poly(D, L-lactide-co-glycolide)/gelatin blend membranes containing Hypericum capitatum var. capitatum

Nazende Nur Aksit et al.

Summary: In this study, PLGA/gelatin membranes containing different amounts of HCC extract were successfully fabricated by electrospinning technique. The membranes exhibited antibacterial activity and showed cytotoxicity toward human fibroblast cells in vitro. The comprehensive investigation also included studies on chemical, morphological, physical, and mechanical properties of the electrospun membranes.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2021)

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Article Materials Science, Textiles

Pine honey-loaded electrospun poly (vinyl alcohol)/gelatin nanofibers with antioxidant properties

Fatma Nur Parin et al.

Summary: This study successfully produced bioactive fibers using electrospinning method with PVA, gelatin, and pine honey. The addition of honey increased fiber diameter and enhanced antioxidant activity. These fibers show potential for biomedical and active food packaging applications.

JOURNAL OF THE TEXTILE INSTITUTE (2021)

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Article Materials Science, Biomaterials

Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing

Yu-Hsiang Lee et al.

Summary: Diabetic foot ulcer is a common complication of diabetes that is difficult to treat and poses a serious threat to the health of patients. A study has developed a composite chitosan-based hydrogel named SNPECHG, which can help improve the healing speed of diabetic wounds.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Engineering, Biomedical

A Hydrogen-Bonded Extracellular Matrix-Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH-Responsive Wound Healing Acceleration

Zainab Ahmadian et al.

Summary: The multifunctional GelTA hydrogel is fabricated through abundant hydrogen bonding among the functional groups of gelatin and tannic acid, showing adjustable physicochemical properties and high safety features. It accelerates wound healing through pH-dependent release of active agents, promotes extracellular matrix formation and wound closure by offering cell adhesion sites, and is a promising candidate for clinical treatment of full-thickness wounds.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Engineering, Biomedical

A novel hot spring-mimetic hydrogel with excellent angiogenic properties for chronic wound healing

Lili Sheng et al.

Summary: The study introduces a novel bioactive photothermal hydrogel with hot spring effect, which stimulates angiogenesis and facilitates chronic wound healing. By releasing bioactive ions and providing heating function, the hydrogel exhibits significant enhancement in vivo.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Exploiting synergistic effect of externally loaded bFGF and endogenous growth factors for accelerated wound healing using heparin functionalized PCL/gelatin co-spun nanofibrous patches

Akshat Joshi et al.

Summary: This study utilized heparin-functionalized nanofabrication technology to successfully sequester exogenous and endogenous growth factors, promoting tissue regeneration. Heparin-functionalized nanofibers showed superior therapeutic capability compared to non-functionalized nanofibers, demonstrating endogenously driven tissue regeneration.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Bio-Templated Metallic Nanomaterial Synthesis and Electrocatalytic Applications

Yani Pan et al.

Summary: Developing metallic nanocatalysts with high activity, selectivity, and durability is an important aspect of electrocatalysis. Biological templates offer a green and controllable approach for the synthesis of these nanomaterials, allowing for enhanced catalytic performance through surface functionalization.

CHEMSUSCHEM (2021)

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Article Biochemistry & Molecular Biology

Cinnamon extract loaded electrospun chitosan/gelatin membrane with antibacterial activity

Soroush Ahmadi et al.

Summary: This study developed chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The incorporation of CE enhanced the properties of the nanofibers, including degradation behavior, antibacterial activity, and biocompatibility. The extract release profile showed a burst release in the first 6 hours, followed by a controlled release in the next 138 hours.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Bacterial Nanocellulose based Wound Dressings: Current and Future Prospects

Hitesh Chopra et al.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Materials Science, Multidisciplinary

Fabrication of polyhydroxy butyric acid-Gelatin blended nanofibrous matrix integrated with silver sulfadiazine as an alternate wound dressing for treating burns

Sekar Jeyakumar Grace Felciya et al.

Summary: The electrospinning of PHB-Gelatin nanofibrous matrix loaded with SSD serves as a stable carrier to prevent infection at burn wound site, reducing dressing frequency and promoting wound healing.

MATERIALS LETTERS (2021)

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Article Biochemistry & Molecular Biology

Synergistic antibacterial polyacrylonitrile/gelatin nanofibers coated with metal-organic frameworks for accelerating wound repair

Jun Yang et al.

Summary: Composite nanofibers prepared by the secondary growth method achieve higher drug loading and adjustable release rate than those prepared by the doping method, demonstrating synergistic antibacterial properties. Gentamicin loaded on ZIF-8 in the composite nanofibers promotes the antibacterial effect, leading to faster wound recovery compared to the doping method, shortening the healing time from 21 days to 16 days in mouse wound infections.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents

Zimkhitha B. Nqakala et al.

Summary: Silver nanoparticles (AgNPs) have shown promise in wound healing due to their broad spectrum antimicrobial properties, low toxicity, efficacy at low concentrations, and lack of skin discoloration. They can be combined with other healing-promoting materials to provide optimal healing outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Polymer Science

Electrospun Functional Nanofiber Membrane for Antibiotic Removal in Water: Review

Kun Zhao et al.

Summary: Antibiotics as a new type of water pollutant have driven the development of new treatment technologies, with electrospun fiber membrane showing excellent benefits in antibiotic removal due to its unique characteristics. This review covers the history, working principle, influencing factors, and process types of electrospinning technology, as well as the preparation technologies of electrospun functional fiber membranes. Recent studies on antibiotic removal by electrospun functional fiber membrane, including adsorption, photocatalysis, and biodegradation, are also reviewed along with future research recommendations.

POLYMERS (2021)

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Review Biochemistry & Molecular Biology

Post Processing Strategies for the Enhancement of Mechanical Properties of ENMs (Electrospun Nanofibrous Membranes): A Review

Saad Nauman et al.

Summary: Electrospinning technique produces fine fibers web with mechanical properties dependent on various factors, requiring post fabrication treatments for enhancing strength. These treatments, including chemical and physical techniques, affect fiber morphology and mechanical properties, with choice based on application area and permissible changes to initial fiber structure.

MEMBRANES (2021)

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Review Pharmacology & Pharmacy

Biopolymer-based Scaffolds for Tissue Engineering Applications

Hitesh Chopra et al.

Summary: Tissue engineering involves the use of cells and polymers, with natural polymers offering advantages over synthetic ones. Various targeted drug delivery systems have been developed using polymers and cells, and dermal substitutes aim to replace skin parts either through grafting or other methods.

CURRENT DRUG TARGETS (2021)

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Review Biochemistry & Molecular Biology

Advances of Microneedles in Biomedical Applications

Jie Xu et al.

Summary: This article discusses the applications of microneedles in biomedical areas, including their classification, manufacturing, drug delivery systems, disease diagnoses, wound repair, and cancer therapy. It also delves into the safety and future prospects of microneedles.

MOLECULES (2021)

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Review Chemistry, Medicinal

Curcumin nanoformulations for antimicrobial and wound healing purposes

Bahare Salehi et al.

Summary: Curcumin, the active ingredient of turmeric, has a long history of medicinal value. Despite its strong antimicrobial potential, issues such as low aqueous solubility and rapid metabolism need to be addressed for better therapeutic efficacy, which can be improved with nanoformulations.

PHYTOTHERAPY RESEARCH (2021)

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Article Nanoscience & Nanotechnology

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

Jiahui He et al.

Summary: A series of injectable pH-responsive self-healing adhesive hydrogels have been developed for treating gastric bleeding and wound healing after endoscopic treatment. These hydrogels show great potential as endoscopic sprayable bioadhesive materials, with good hemostatic properties and enhanced wound healing effects in animal models.

NANO-MICRO LETTERS (2021)

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Article Instruments & Instrumentation

Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems

Pia Kaiser et al.

Summary: The treatment of infected wounds is challenged by inadequate drug concentrations, development of antibiotic resistance, and cytotoxicity of antiseptics. Advanced drug delivery systems have the potential to enable tailor-made application of antimicrobials, resulting in effective treatment of infected wounds.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Pharmacology & Pharmacy

Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments

Anam Razzaq et al.

Summary: This study prepared gelatin/polyvinyl alcohol nanofibers loaded with the antibiotic cephradine for the treatment of diabetic wound infections. The drug-loaded nanofibers exhibited superior thermal stability and sustained drug release, as well as stronger antibacterial activity both in vitro and in vivo. They were also found to be safer and more effective for promoting diabetic chronic wound healing, indicating their potential as valuable dressing materials for diabetic patients.

PHARMACEUTICS (2021)

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Article Multidisciplinary Sciences

Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels

Sakkarin Bhubhanil et al.

Summary: The study demonstrates that guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional wound healing and antibacterial properties. The composite shows excellent results in promoting cell proliferation, migration, and collagen production, as well as various beneficial effects in animal studies on wound healing.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Multidisciplinary

Electrospun Aspirin/Eudragit/Lipid Hybrid Nanofibers for Colon-targeted Delivery Using an Energy-saving Process

Yibin Wang et al.

Summary: This paper introduces a new coaxial spinneret with a solid core and the development of medicated Eudragit/lipid hybrid nanofibers for colon-targeted sustained release of aspirin. Characterization and in vitro dissolution tests show that the hybrid nanofibers effectively prevent aspirin release under acidic conditions and prolong release time under neutral conditions. The energy-saving mechanism is discussed, and the prepared aspirin-loaded hybrid nanofibers could be potentially used for countering COVID-19 in the future.

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES (2021)

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Review Chemistry, Multidisciplinary

Electrospun Nanofibrous Adsorption Membranes for Wastewater Treatment: Mechanical Strength Enhancement

Xin Rui et al.

Summary: Functional nanofibrous membranes fabricated by electrospinning technology show great potential in the removal of heavy metal ions from wastewater, but their poor mechanical properties may limit their practical applications. Various strategies and methodologies have been explored to overcome this issue, ensuring the recyclability and reusability of the membranes during the adsorption process.

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES (2021)

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Article Engineering, Environmental

ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFicB p65 and cysteine deficiency in keratinocytes

Xuan Lai et al.

Summary: This study found that zinc oxide nanoparticles can enter psoriasis-like skin lesions and promote inflammation and keratinocyte apoptosis through nuclear translocation of p-NFicB p65 and cysteine deficiency. The research serves as a reminder to the public that ZnO NPs have harmful effects on the recovery of inflammatory skin diseases.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Engineering, Biomedical

Determination of the mechanical properties of polymeric microneedles by micromanipulation

Guangsheng Du et al.

Summary: This study used micromanipulation technique to determine the mechanical strength of two types of hyaluronic acid microneedles, one loaded with model drugs and the other without. The data obtained suggest that the molecular weight of the polymer and the loading of drug into the microneedles significantly affect the rupture behavior and mechanical properties of the microneedles, providing a foundation for preparing sufficiently strong microneedles for controlled drug delivery.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

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Article Engineering, Biomedical

Zn-MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Shun Yao et al.

Summary: A degradable zinc-MOF encapsulated microneedles array was fabricated in this study, showing excellent antibacterial activity and biocompatibility, which can accelerate wound healing and tissue regeneration.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing

Simarjot Kaur Sandhu et al.

Summary: This study aimed to develop high drug-loaded curcumin solid lipid nanoparticles (CSLNs) for wound healing, showing superior drug release properties and antimicrobial effects. The CSLNs exhibited excellent safety, stability, controlled release, and disruption of mature biofilms, both in vitro and in vivo.

ANTIOXIDANTS (2021)

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Article Engineering, Biomedical

Nanoparticle-driven self-assembling injectable hydrogels provide a multi-factorial approach for chronic wound treatment

Silvia Perez-Rafael et al.

Summary: This study developed a novel multifunctional hydrogel for the treatment of chronic wounds, showing significant efficacy in inhibiting harmful enzymes, reducing bacterial load, and promoting tissue remodeling and skin integrity restoration. It possesses antibacterial and antioxidant properties and is non-toxic to human keratinocytes after direct contact, making it a promising candidate for chronic wound management.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Technological advances towards extracellular vesicles mass production

Alice Grangier et al.

Summary: Extracellular vesicles (EVs) play essential roles in bio-therapeutics as both therapeutic agents and cargo delivery vehicles. Challenges remain in achieving large-scale production to reduce treatment costs, and current research is focused on developing high-yield manufacturing methods through platforms like large-scale cell cultures and cell stimulation techniques.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Medical Informatics

Modeling and prediction of pressure injury in hospitalized patients using artificial intelligence

Christine Anderson et al.

Summary: Hospital-acquired pressure injuries (PIs) cause significant patient suffering, increased healthcare costs, and more clinical co-morbidities. This study used AI to predict PI development, finding that model-free techniques outperformed model-based forecasts, with Random forest consistently generating optimal PI predictions.

BMC MEDICAL INFORMATICS AND DECISION MAKING (2021)

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Article Pharmacology & Pharmacy

Fabrication of scaffold based on gelatin and polycaprolactone (PCL) for wound dressing application

Gomaa El Fawal et al.

Summary: The study prepared an antimicrobial and antioxidant scaffold (PCL/Gel/Oil) using electrospinning technique, demonstrating changes in fiber morphology and promising biocompatibility and antibacterial activity for wound dressing application.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Applications of Nanosized-Lipid-Based Drug Delivery Systems in Wound Care

Andreea-Mariana Matei et al.

Summary: Impaired wound healing is a significant public health issue, prompting the need for developing new therapies. Nanotechnology offers a promising approach to enhance treatment efficacy and manage wounds by addressing issues such as drug permeability and bioavailability. This paper focuses on the application of nanosized-lipid-based drug delivery systems in wound care, highlighting their potential benefits in comparison to conventional treatments.

APPLIED SCIENCES-BASEL (2021)

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Review Materials Science, Multidisciplinary

Developments of Advanced Electrospinning Techniques: A Critical Review

Ya Li et al.

Summary: Electrospinning, a low-cost and straightforward method, has attracted great attention for its functional nanofibrous materials that can be widely used in various fields. This paper comprehensively reviews the latest advances in developing this unique technique and provides a future vision for challenges and perspectives in the field.

ADVANCED MATERIALS TECHNOLOGIES (2021)

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Review Medicine, General & Internal

Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers

Robert G. Frykberg

Summary: Oxygen is crucial for wound healing, and providing supplemental oxygen can enhance tissue repair in hypoxic chronic wounds. While hyperbaric oxygen therapy has not shown clear evidence to support its effectiveness in healing chronic diabetic foot ulcers, topical oxygen therapy has been proven to improve healing rates in clinical studies.

MEDICINA-LITHUANIA (2021)

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Article Biochemistry & Molecular Biology

Effective Scarless Wound Healing Mediated by Erbium Borate Nanoparticles

Oguz Kaan Kirbas et al.

Summary: The study investigates the boosting effects of erbium borate nanoparticles on wound healing process, particularly scarless healing. Through experiments, it has been shown that these nanoparticles can accelerate scar tissue improvement and have potential for scarless healing. This conclusion is supported by MTS assay, quantitative PCR analysis, reactive oxygen species assay, and scratch assay.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Review Medicine, General & Internal

Stem cell-derived exosomes for wound healing: current status and promising directions

Ngoc B. Vu et al.

Summary: Stem cell therapy plays a significant role in the healing of chronic wounds, however, it is complex, expensive, and time-consuming. Recent studies suggest that stem cell-derived exosomes can be an effective treatment for wounds, inducing positive effects in various stages of wound healing.

MINERVA MEDICA (2021)

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Review Materials Science, Multidisciplinary

Nanomaterials: a review of synthesis methods, properties, recent progress, and challenges

Nadeem Baig et al.

Summary: Nanomaterials are a class of materials with exceptional properties that can be tuned through design, playing a crucial role in the advancement of nanotechnology. Various synthesis methods and unique features of nanomaterials have been discussed in this review, along with a brief history and future perspectives in the field.

MATERIALS ADVANCES (2021)

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Article Pharmacology & Pharmacy

Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

Lianlian Cao et al.

Summary: This study aimed to establish wound bandages composition based on Cerium nanoparticle-loaded polyvinyl alcohol nanogels and investigated the effects of different experimental limitations on PVA nanogel formations. Results showed that Ce-nGel-Glu-treated wounds healed faster with less damage, indicating the potential of Ce-nGel-Glu for future wound healing applications.

DRUG DELIVERY (2021)

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Article Materials Science, Biomaterials

Cerium Oxide Nanoparticle Incorporated Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Membranes for Diabetic Wound Healing Applications

Robin Augustine et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Engineering, Environmental

Silver nanoparticle-embedded hydrogel as a photothermal platform for combating bacterial infections

Yingnan Liu et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Materials Science, Multidisciplinary

Synthesis of molecularly imprinted polymer nanoparticles containing gentamicin drug as wound dressing based polyvinyl alcohol/gelatin nanofiber

Masoumeh Foroutan Koudehi et al.

MATERIALS TECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Encapsulation of curcumin loaded chitosan nanoparticle within poly (ε-caprolactone) and gelatin fiber mat for wound healing and layered dermal reconstitution

Maria Zahiri et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Pharmacology & Pharmacy

Wound healing with alginate/chitosan hydrogel containing hesperidin in rat model

Zohreh Bagher et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Article Polymer Science

Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg-Al]-layered double hydroxide as an antimicrobial wound dressing

Joao O. D. Malafatti et al.

POLYMERS FOR ADVANCED TECHNOLOGIES (2020)

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Article Dermatology

Development of a Model to Predict Healing of Chronic Wounds Within 12 Weeks

Sang Kyu Cho et al.

ADVANCES IN WOUND CARE (2020)

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Article Chemistry, Physical

Preparation of PCL/(+)-catechin/gelatin film for wound healing using air-jet spinning

Seungho Baek et al.

APPLIED SURFACE SCIENCE (2020)

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Review Pharmacology & Pharmacy

Lipid Nanoparticles as a Skin Wound Healing Drug Delivery System: Discoveries and Advances

Myla Lobo de Souza et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Review Chemistry, Multidisciplinary

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

Elena Sanchez-Lopez et al.

NANOMATERIALS (2020)

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Article Biochemistry & Molecular Biology

Cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose-grapefruit seed extract nanoparticles for potential wound healing applications

Aditya Koneru et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Multidisciplinary Sciences

Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies

Hadi Samadian et al.

SCIENTIFIC REPORTS (2020)

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Review Chemistry, Multidisciplinary

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Shi Su et al.

NANOMATERIALS (2020)

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Review Chemistry, Multidisciplinary

Nanomaterials in Cosmetics: Recent Updates

Georgios Fytianos et al.

NANOMATERIALS (2020)

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Article Nanoscience & Nanotechnology

alpha-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring

Xiong Guo et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Environmental

Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds

Jiahui He et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Applied

Fabrication and characterization of matrine-loaded konjac glucomannan/fish gelatin composite hydrogel as antimicrobial wound dressing

Liping Zhou et al.

FOOD HYDROCOLLOIDS (2020)

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Article Chemistry, Applied

Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies

M. R. El-Aassar et al.

CARBOHYDRATE POLYMERS (2020)

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Review Biochemistry & Molecular Biology

Nanomaterials for Wound Dressings: An Up-to-Date Overview

Alexandra Elena Stoica et al.

MOLECULES (2020)

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Article Multidisciplinary Sciences

Manuka honey microneedles for enhanced wound healing and the prevention and/or treatment of Methicillin-resistant Staphylococcus aureus (MRSA) surgical site infection

Galit H. Frydman et al.

SCIENTIFIC REPORTS (2020)

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Letter Environmental Sciences

Skin inflammation and psoriasis may be linked to exposure of ultrafine carbon particles

Huyan Xiao et al.

JOURNAL OF ENVIRONMENTAL SCIENCES (2020)

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Article Materials Science, Biomaterials

Tazarotene-loaded PLGA nanoparticles potentiate deep tissue pressure injury healing via VEGF-Notch signaling

Panpan Liu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Review Nanoscience & Nanotechnology

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Matias Guerrero Correa et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2020)

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Article Materials Science, Multidisciplinary

Nitric oxide released injectable hydrogel combined with synergistic photothermal therapy for antibacterial and accelerated wound healing

Huiling Liu et al.

APPLIED MATERIALS TODAY (2020)

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Review Nanoscience & Nanotechnology

Optimized Synthesis Approaches of Metal Nanoparticles with Antimicrobial Applications

Liliana Marinescu et al.

JOURNAL OF NANOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Exosomes for Wound Healing: Purification Optimization and Identification of Bioactive Components

Britta F. Hettich et al.

ADVANCED SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Nanofibrous cellulose acetate/gelatin wound dressing endowed with antibacterial and healing efficacy using nanoemulsion of Zataria multiflora

Hossein Farahani et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Materials Science, Biomaterials

Liraglutide-loaded PLGA/gelatin electrospun nanofibrous mats promote angiogenesis to accelerate diabetic wound healing via the modulation of miR-29b-3p

Muyu Yu et al.

BIOMATERIALS SCIENCE (2020)

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Article Engineering, Biomedical

Porous electrospun poly(ε-caprolactone)/gelatin nanofibrous mat containing cinnamon for wound healing application: in vitro and in vivo study

Majid Salehi et al.

BIOMEDICAL ENGINEERING LETTERS (2020)

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Article Dermatology

Treatment of Atrophic Facial Acne Scars With Microneedling Followed by Polymethylmethacrylate-Collagen Gel Dermal Filler

Brian S. Biesman et al.

DERMATOLOGIC SURGERY (2019)

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Review Biochemistry & Molecular Biology

Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management

Veena Vijayakumar et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Biochemistry & Molecular Biology

Controlled release of lawsone from polycaprolactone/gelatin electrospun nano fibers for skin tissue regeneration

Mahboobeh Adeli-Sardou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Pharmacology & Pharmacy

In vitro and in vivo studies of novel fabricated bioactive dressings based on collagen and zinc oxide 3D scaffolds

Paul Catalin Balaure et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Biochemistry & Molecular Biology

Characterization of Collagen/Lipid Nanoparticle-Curcumin Cryostructurates for Wound Healing Applications

Valentina Laghezza Masci et al.

MACROMOLECULAR BIOSCIENCE (2019)

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Review Biochemistry & Molecular Biology

Fabrication of Electrospun Polymer Nanofibers with Diverse Morphologies

Chenyu Wang et al.

MOLECULES (2019)

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Article Chemistry, Multidisciplinary

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing

Yongping Liang et al.

SMALL (2019)

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Review Chemistry, Multidisciplinary

Nanomaterials for the Removal of Heavy Metals from Wastewater

Jinyue Yang et al.

NANOMATERIALS (2019)

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Article Polymer Science

Construction of Antibacterial N ‐Halamine Polymer Nanomaterials Capable of Bacterial Membrane Disruption for Efficient Anti‐Infective Wound Therapy

Yangyang Gao et al.

MACROMOLECULAR BIOSCIENCE (2019)

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Article Materials Science, Biomaterials

Carica papaya loaded poly (vinyl alcohol)-gelatin nanofibrous scaffold for potential application in wound dressing

Jyoti Ahlawat et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Cell Biology

Nanofiber-hydrogel composite-mediated angiogenesis for soft tissue reconstruction

Xiaowei Li et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Pharmacology & Pharmacy

Gold nanoparticles loaded into polymeric hydrogel for wound healing in rats: Effect of nanoparticles' shape and surface modification

Nouf N. Mahmoud et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Chemistry, Physical

Nanomaterials for Wound Healing and Infection Control

Mara Madalina Mihai et al.

MATERIALS (2019)

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Article Nanoscience & Nanotechnology

Tazarotene Released from Aligned Electrospun Membrane Facilitates Cutaneous Wound Healing by Promoting Angiogenesis

Zhou Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release

Min Wang et al.

ACS NANO (2019)

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Article Pharmacology & Pharmacy

In vivo study of silk fibroin/gelatin electrospun nanofiber dressing loaded with astragaloside IV on the effect of promoting wound healing and relieving scar

Danping Zhang et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

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Review Pharmacology & Pharmacy

Aspects of Nanomaterials in Wound Healing

Srijita Chakrabarti et al.

CURRENT DRUG DELIVERY (2019)

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Article Chemistry, Physical

Mussel-inspired, antibacterial, conductive, antioxidant, injectable composite hydrogel wound dressing to promote the regeneration of infected skin

Yongping Liang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Review Pharmacology & Pharmacy

Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery

Marcin Makowski et al.

PHARMACEUTICS (2019)

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Article Pharmacology & Pharmacy

Evaluation of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Mats Containing Clove Essential Oil for Antibacterial Wound Dressing

Irem Unalan et al.

PHARMACEUTICS (2019)

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Article Chemistry, Applied

Antibacterial poly (ethylene glycol) diacrylate/chitosan hydrogels enhance mechanical adhesiveness and promote skin regeneration

Lin Huang et al.

CARBOHYDRATE POLYMERS (2019)

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Article Pharmacology & Pharmacy

Silver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits

Nosheen Masood et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Biotechnology & Applied Microbiology

Possible applications of metal nanoparticles in antimicrobial food packaging

Renata Dobrucka et al.

JOURNAL OF FOOD SAFETY (2019)

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Article Immunology

Biogenic Au@ZnO core-shell nanocomposites kill Staphylococcus aureus without provoking nuclear damage and cytotoxicity in mouse fibroblasts cells under hyperglycemic condition with enhanced wound healing proficiency

Md Imran Khan et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2019)

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Article Toxicology

Multi-walled carbon nanotube oxidation dependent keratinocyte cytotoxicity and skin inflammation

Brian C. Palmer et al.

PARTICLE AND FIBRE TOXICOLOGY (2019)

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Article Materials Science, Multidisciplinary

Antibacterial activity and in vivo wound healing evaluation of polycaprolactone-gelatin methacryloyl-cephalexin electrospun nanofibrous

H. R. Bakhsheshi-Rad et al.

MATERIALS LETTERS (2019)

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Article Materials Science, Biomaterials

Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing

Shaohan Zhang et al.

BIOMATERIALS SCIENCE (2019)

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Review Pharmacology & Pharmacy

Skin toxicity of topically applied nanoparticles

Sara Hashempour et al.

THERAPEUTIC DELIVERY (2019)

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Article Chemistry, Multidisciplinary

Fabrication of centrifugally spun prepared poly(lactic acid)/gelatin/ciprofloxacin nanofibers for antimicrobial wound dressing

Lei Xia et al.

RSC ADVANCES (2019)

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Article Nanoscience & Nanotechnology

Essential oil-loaded lipid nanoparticles for wound healing

Francesca Saporito et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Biotechnology & Applied Microbiology

Taurine-loaded poly (ε-caprolactone)/gelatin electrospun mat as a potential wound dressing material: In vitro and in vivo evaluation

Saeed Farzamfar et al.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2018)

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Review Pharmacology & Pharmacy

In situ forming injectable hydrogels for drug delivery and wound repair

Robert Dimatteo et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Review Biochemistry & Molecular Biology

Recent advances on silver nanoparticle and biopolymer-based biomaterials for wound healing applications

Sathish Sundar Dhilip Kumar et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

Incorporation of ZnO nanoparticles into heparinised polyvinyl alcohol/chitosan hydrogels for wound dressing application

Mohammad Taghi Khorasani et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

The antibacterial and anti-inflammatory investigation of Lawsonia Inermis-gelatin-starch nano-fibrous dressing in burn wound

Zhina Hadisi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Biochemistry & Molecular Biology

Nanocoatings for Chronic Wound Repair-Modulation of Microbial Colonization and Biofilm Formation

Mara Madalina Mihai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

A Current Overview of the Biological and Cellular Effects of Nanosilver

Shana J. Cameron et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Nanoscience & Nanotechnology

Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)

Xiaoyu Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Chemistry, Physical

Long-acting and broad-spectrum antimicrobial electrospun poly (epsilon-caprolactone)/gelatin micro/nanofibers for wound dressing

Rui Shi et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2018)

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Review Pharmacology & Pharmacy

A review on nanoparticle based treatment for wound healing

Naresh Kumar Rajendran et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Development of biosynthesized silver nanoparticles based formulation for treating wounds during nursing care in hospitals

Cui-Ping Gong et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2018)

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Article Engineering, Biomedical

Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing

Seungkuk Ahn et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Physiology

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

Paulina Krzyszczyk et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing

Rashid Ahmed et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Nanoscience & Nanotechnology

Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

Menglei Wang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Nanoscience & Nanotechnology

Antibacterial and biodegradable tissue nano-adhesives for rapid wound closure

Meng-meng Lu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Multidisciplinary Sciences

Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents

Mona G. Arafa et al.

SCIENTIFIC REPORTS (2018)

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Article Engineering, Biomedical

A pH-Mediated Electronic Wound Dressing for Controlled Drug Delivery

Gita Kiaee et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Biochemistry & Molecular Biology

Metal nanoparticles in dermatology and cosmetology: Interactions with human skin cells

Karolina Niska et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2018)

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Article Cell & Tissue Engineering

Wound-healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model

Chun-Hsu Yao et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

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Article Cell & Tissue Engineering

Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model

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STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Article Biochemistry & Molecular Biology

In vivo diabetic wound healing potential of nanobiocomposites containing bamboo cellulose nanocrystals impregnated with silver nanoparticles

Rubbel Singla et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Article Nanoscience & Nanotechnology

Antibacterial activity of gold nanorods against Staphylococcus aureus and Propionibacterium acnes: misinterpretations and artifacts

Nouf N. Mahmoud et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Engineering, Biomedical

Gelatin/chondroitin sulfate nanofibrous scaffolds for stimulation of wound healing: In-vitro and in-vivo study

Mohamad Pezeshki-Modaress et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)

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Article Materials Science, Biomaterials

Novel poly(ε-caprolactone)/gelatin wound dressings prepared by emulsion electrospinning with controlled release capacity of Ketoprofen anti-inflammatory drug

A. O. Basar et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Materials Science, Biomaterials

Strong and tough nanofibrous hydrogel composites based on biomimetic principles

Khaow Tonsomboon et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Dermatology

Therapeutic effect of microneedling and autologous platelet-rich plasma in the treatment of atrophic scars: A randomized study

Zeinab A. Ibrahim et al.

JOURNAL OF COSMETIC DERMATOLOGY (2017)

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Article Multidisciplinary Sciences

Silver nanoparticle loaded collagen/chitosan scaffolds promote wound healing via regulating fibroblast migration and macrophage activation

Chuangang You et al.

SCIENTIFIC REPORTS (2017)

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Article Nanoscience & Nanotechnology

pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing

Lingling Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Engineering, Biomedical

Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing

Nasim Annabi et al.

BIOMATERIALS (2017)

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Article Chemistry, Applied

Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds

Ayesha Khalid et al.

CARBOHYDRATE POLYMERS (2017)

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Synthesis and Fabrication of Collagen-Coated Ostholamide Electrospun Nanofiber Scaffold for Wound Healing

Subramani Kandhasamy et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Engineering, Biomedical

Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

Xin Zhao et al.

BIOMATERIALS (2017)

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Article Chemistry, Applied

Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata polysaccharide for wound healing applications

Lang Ding et al.

CARBOHYDRATE POLYMERS (2017)

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Article Engineering, Biomedical

Cell infiltrative hydrogel fibrous scaffolds for accelerated wound healing

Xin Zhao et al.

ACTA BIOMATERIALIA (2017)

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Article Pharmacology & Pharmacy

Collagen nanofiber containing silver nanoparticles for improved wound-healing applications

Goutam Rath et al.

JOURNAL OF DRUG TARGETING (2016)

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Honey/Chitosan Nanofiber Wound Dressing Enriched with Allium sativum and Cleome droserifolia: Enhanced Antimicrobial and Wound Healing Activity

Wessam A. Sarhan et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Nanoscience & Nanotechnology

Functional Silver Nanoparticle as a Benign Antimicrobial Agent That Eradicates Antibiotic-Resistant Bacteria and Promotes Wound Healing

Xiaomei Dai et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Nanoscience & Nanotechnology

Antibacterial and Anti-Inflammatory pH-Responsive Tannic Acid-Carboxylated Agarose Composite Hydrogels for Wound Healing

Neethu Ninan et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Engineering, Biomedical

Multi-biofunction of antimicrobial peptide-immobilized silk fibroin nanofiber membrane: Implications for wound healing

Dae Woong Song et al.

ACTA BIOMATERIALIA (2016)

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Article Biochemistry & Molecular Biology

In Situ Synthesis of Antimicrobial Silver Nanoparticles within Antifouling Zwitterionic Hydrogels by Catecholic Redox Chemistry for Wound Healing Application

Amin GhavamiNejad et al.

BIOMACROMOLECULES (2016)

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Review Cell Biology

Epithelial-mesenchymal transition in tissue repair and fibrosis

Rivka C. Stone et al.

CELL AND TISSUE RESEARCH (2016)

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Review Biochemistry & Molecular Biology

Transition from inflammation to proliferation: a critical step during wound healing

Ning Xu Landen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

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Preparation and Characterization of Ceftazidime Loaded Electrospun Silk Fibroin/Gelatin Mat for Wound Dressing

Masumeh Safdari et al.

FIBERS AND POLYMERS (2016)

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Article Nanoscience & Nanotechnology

Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFβ1/Smad signaling pathway

Chen-wen Li et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

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Article Immunology

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

Audrey Nosbaum et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Nanoscience & Nanotechnology

Spirulina-PCL Nanofiber Wound Dressing to Improve Cutaneous Wound Healing by Enhancing Antioxidative Mechanism

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JOURNAL OF NANOMATERIALS (2016)

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Article Nanoscience & Nanotechnology

Application of Cryopreserved Fibroblast Culture with Au Nanoparticles to Treat Burns

Nataliia Volkova et al.

NANOSCALE RESEARCH LETTERS (2016)

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Current Concepts in Tissue Engineering: Skin and Wound

Mayer Tenenhaus et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2016)

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Article Nanoscience & Nanotechnology

Application of Cryopreserved Fibroblast Culture with Au Nanoparticles to Treat Burns

Nataliia Volkova et al.

NANOSCALE RESEARCH LETTERS (2016)

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Review Cell & Tissue Engineering

Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform?

Deyun Chen et al.

STEM CELLS INTERNATIONAL (2016)

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Review Cell Biology

Cellular mechanisms of skin repair in humans and other mammals

Laure Rittie

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2016)

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Electrospun gelatin nanofibers loaded with vitamins A and E as antibacterial wound dressing materials

Heyu Li et al.

RSC ADVANCES (2016)

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Review Dermatology

Cellular and molecular mechanisms of repair in acute and chronic wound healing

P. Martin et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

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Review Cell & Tissue Engineering

Stem Cell Heterogeneity and Plasticity in Epithelia

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CELL STEM CELL (2015)

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Article Biochemistry & Molecular Biology

Evaluation of biomaterial containing regenerated cellulose and chitosan incorporated with silver nanoparticles

M. I. Niyas Ahamed et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Pharmacology & Pharmacy

Silk fibroin/gelatin electrospun nanofibrous dressing functionalized with astragaloside IV induces healing and anti-scar effects on burn wound

Ying-Hui Shan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Article Nanoscience & Nanotechnology

Hybrid Nanoscale Architecture of Wound Dressing with Super Hydrophilic, Antimicrobial, and Ultralow Fouling Attributes

D. Depan et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2015)

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Article Oncology

Macrophage PPAR and impaired wound healing in type 2 diabetes

Rita E. Mirza et al.

JOURNAL OF PATHOLOGY (2015)

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Review Materials Science, Biomaterials

Lipid-coated polymeric nanoparticles for cancer drug delivery

Sangeetha Krishnamurthy et al.

BIOMATERIALS SCIENCE (2015)

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Article Materials Science, Biomaterials

Fibrous wound dressings encapsulating essential oils as natural antimicrobial agents

I. Liakos et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

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Article Nanoscience & Nanotechnology

The Application of Bactericidal Silver Nanoparticles in Wound Treatment

Geewoo Nam et al.

NANOMATERIALS AND NANOTECHNOLOGY (2015)

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Review Immunology

How leukocytes cross the vascular endothelium

Dietmar Vestweber

NATURE REVIEWS IMMUNOLOGY (2015)

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Bioactive compound loaded stable silver nanoparticle synthesis from microwave irradiated aqueous extracellular leaf extracts of Naringi crenulata and its wound healing activity in experimental rat model

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ACTA TROPICA (2014)

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Review Infectious Diseases

Oral antibiotic therapy for the treatment of infective endocarditis: a systematic review

Awad Al-Omari et al.

BMC INFECTIOUS DISEASES (2014)

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Article Engineering, Biomedical

Evaluation of various silver-containing dressing on infected excision wound healing study

Yu-Hsin Lin et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2014)

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Review Multidisciplinary Sciences

STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration

Cedric Blanpain et al.

SCIENCE (2014)

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Review Cell Biology

Wound repair and regeneration: Mechanisms, signaling, and translation

Sabine A. Eming et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Deregulation of epidermal stem cell niche contributes to pathogenesis of nonhealing venous ulcers

Olivera Stojadinovic et al.

WOUND REPAIR AND REGENERATION (2014)

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Review Cell Biology

The effects of pH on wound healing, biofilms, and antimicrobial efficacy

Steven L. Percival et al.

WOUND REPAIR AND REGENERATION (2014)

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Innate and Adaptive Immune Responses in Wound Epithelialization

Natasa Strbo et al.

ADVANCES IN WOUND CARE (2014)

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Review Dermatology

Epithelialization in Wound Healing: A Comprehensive Review

Irena Pastar et al.

ADVANCES IN WOUND CARE (2014)

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Review Dermatology

Wound Dressings and Comparative Effectiveness Data

Aditya Sood et al.

ADVANCES IN WOUND CARE (2014)

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Review Pharmacology & Pharmacy

Liposomal drug delivery systems: From concept to clinical applications

Theresa M. Allen et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Review Pharmacology & Pharmacy

Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review

Kunn Hadinoto et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2013)

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Article Polymer Science

Preparation and performance evaluations of electrospun poly(ε-caprolactone), poly(lactic acid), and their hybrid (50/50) nanofibrous mats containing thymol as an herbal drug for effective wound healing

Zeinab Karami et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2013)

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Article Biophysics

The natural medications for wound healing - Curcumin, Aloe-Vera and Ginger - do not induce a significant effect on the migration kinematics of cultured fibroblasts

Gil Topman et al.

JOURNAL OF BIOMECHANICS (2013)

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Article Nanoscience & Nanotechnology

Burn-Wound Healing Effect of Gelatin/Polyurethane Nanofiber Scaffold Containing Silver-Sulfadiazine

Dong Nyoung Heo et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2013)

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Article Nanoscience & Nanotechnology

Wound healing and antibacterial activities of chondroitin sulfate- and acharan sulfate-reduced silver nanoparticles

A-Rang Im et al.

NANOTECHNOLOGY (2013)

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Article Cell Biology

Comparative wound healing - Are the small animal veterinarian's clinical patients an improved translational model for human wound healing research?

Susan W. Volk et al.

WOUND REPAIR AND REGENERATION (2013)

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Article Biotechnology & Applied Microbiology

New Guar Biopolymer Silver Nanocomposites for Wound Healing Applications

Runa Ghosh Auddy et al.

BIOMED RESEARCH INTERNATIONAL (2013)

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Review Dermatology

Proteases and Delayed Wound Healing

Sara M. McCarty et al.

ADVANCES IN WOUND CARE (2013)

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Review Dermatology

Disclosure of the Culprits: Macrophages-Versatile Regulators of Wound Healing

Anca Sindrilaru et al.

ADVANCES IN WOUND CARE (2013)

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Article Biochemistry & Molecular Biology

Chitosan Microneedle Patches for Sustained Transdermal Delivery of Macromolecules

Mei-Chin Chen et al.

BIOMACROMOLECULES (2012)

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Article Cardiac & Cardiovascular Systems

Waon Therapy Upregulates Hsp90 and Leads to Angiogenesis Through the Akt-Endothelial Nitric Oxide Synthase Pathway in Mouse Hindlimb Ischemia

Takahiro Miyauchi et al.

CIRCULATION JOURNAL (2012)

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Article Cell Biology

The role of endogenous and exogenous enzymes in chronic wounds: A focus on the implications of aberrant levels of both host and bacterial proteases in wound healing

Sara M. McCarty et al.

WOUND REPAIR AND REGENERATION (2012)

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Article Engineering, Biomedical

Wound-Healing with Mechanically Robust and Biodegradable Hydrogel Fibers Loaded with Silver Nanoparticles

Kevin Neibert et al.

ADVANCED HEALTHCARE MATERIALS (2012)

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Review Pathology

Wound Macrophages as Key Regulators of Repair Origin, Phenotype, and Function

Samielle K. Brancato et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

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Article Surgery

Bone Marrow-derived Mesenchymal Stem Cells Transplantation Accelerates Tissue Expansion by Promoting Skin Regeneration During Expansion

Mei Yang et al.

ANNALS OF SURGERY (2011)

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Article Chemistry, Physical

Synthesis and characterization of zinc/iron oxide composite nanoparticles and their antibacterial properties

Tamar Gordon et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2011)

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Article Biophysics

Factors affecting drug encapsulation and stability of lipid-polymer hybrid nanoparticles

Wean Sin Cheow et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2011)

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Article Nanoscience & Nanotechnology

Superior Wound Healing Effect of Topically Delivered Silver Nanoparticle Formulation Using Eco-Friendly Potato Plant Pathogenic Fungus: Synthesis and Characterization

G. Thirumurugan et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2011)

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Article Medicine, Research & Experimental

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

Anca Sindrilaru et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

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Review Immunology

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

Stephen J. Galli et al.

NATURE IMMUNOLOGY (2011)

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Article Toxicology

Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles

Kyeongah Kang et al.

TOXICOLOGY LETTERS (2011)

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Review Critical Care Medicine

Hacking into bacterial biofilms: a new therapeutic challenge

Christophe Bordi et al.

ANNALS OF INTENSIVE CARE (2011)

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Article Engineering, Biomedical

Development of bioactive peptide amphiphiles for therapeutic cell delivery

Matthew J. Webber et al.

ACTA BIOMATERIALIA (2010)

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Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

CELL (2010)

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Article Chemistry, Medicinal

Silver Nanoparticles Mediate Differential Responses in Keratinocytes and Fibroblasts during Skin Wound Healing

Xuelai Liu et al.

CHEMMEDCHEM (2010)

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Review Biochemistry & Molecular Biology

Development of Nanoparticles for Antimicrobial Drug Delivery

L. Zhang et al.

CURRENT MEDICINAL CHEMISTRY (2010)

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Article Immunology

Differential Roles of Macrophages in Diverse Phases of Skin Repair

Tina Lucas et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Medicine, General & Internal

Emerging peptide nanomedicine to regenerate tissues and organs

M. J. Webber et al.

JOURNAL OF INTERNAL MEDICINE (2010)

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Article Multidisciplinary Sciences

Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice

Savita Khanna et al.

PLOS ONE (2010)

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Article Chemistry, Multidisciplinary

Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Polymeric Nanoparticles Against E. coli Biofilm Cells: The Effect of Antibiotic Release Profile

Wean Sin Cheow et al.

PHARMACEUTICAL RESEARCH (2010)

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Article Surgery

A retrospective analysis of ambulatory burn patients: focus on wound dressings and healing times

Gianpiero Gravante et al.

ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND (2010)

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Review Chemistry, Medicinal

Bacterial Toxins: An Overview on Bacterial Proteases and their Action as Virulence Factors

I. Lebrun et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)

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Review Pharmacology & Pharmacy

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

Yogeshkumar Malam et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

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Article Chemistry, Multidisciplinary

Fmoc-Diphenylalanine self assembles to a hydrogel via a novel architecture based on π-π interlocked β-sheets

Andrew M. Smith et al.

ADVANCED MATERIALS (2008)

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Article Critical Care Medicine

Construction, application and biosafety of silver nanocrystalline chitosan wound dressing

Shuanyun Lu et al.

BURNS (2008)

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Article Pharmacology & Pharmacy

Heat Stress and Hormetin-Induced Hormesis in Human Cells: Effects on Aging, Wound Healing, Angiogenesis, and Differentiation

Suresh I. S. Rattan et al.

Dose-Response (2008)

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Article Microbiology

Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms

Nicole Jones et al.

FEMS MICROBIOLOGY LETTERS (2008)

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Article Cell & Tissue Engineering

Three-dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel

Sihong Wang et al.

TISSUE ENGINEERING PART A (2008)

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Article Biochemistry & Molecular Biology

Three-dimensional cell culture of chondrocytes on modified di-phenylaianine scaffolds

V. Jayawarna et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

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Article Nanoscience & Nanotechnology

Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles

Farnaz Esmaeili et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2007)

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Article Chemistry, Medicinal

Topical delivery of silver nanoparticles promotes wound healing

Jun Tian et al.

CHEMMEDCHEM (2007)

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Article Chemistry, Multidisciplinary

Polymer microneedles for controlled-release drug delivery

Jung-Hwan Park et al.

PHARMACEUTICAL RESEARCH (2006)

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Article Dermatology

Near infrared laser-tissue welding using nanoshells as an exogenous absorber

AM Gobin et al.

LASERS IN SURGERY AND MEDICINE (2005)

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Review Oncology

Cellular and molecular facets of keratinocyte reepithelization during wound healing

MM Santoro et al.

EXPERIMENTAL CELL RESEARCH (2005)

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Article Infectious Diseases

Liposome-mediated gentamicin delivery:: development and activity against resistant strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients

C Mugabe et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)

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Article Cell Biology

Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement

R Farooqui et al.

JOURNAL OF CELL SCIENCE (2005)

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Article Multidisciplinary Sciences

Rho-dependent formation of epithelial leader cells during wound healing

T Omelchenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Review Physiology

Regulation of wound healing by growth factors and cytokines

S Werner et al.

PHYSIOLOGICAL REVIEWS (2003)

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Article Biochemistry & Molecular Biology

Wound healing in the PU.1 null mouse - Tissue repair is not dependent on inflammatory cells

P Martin et al.

CURRENT BIOLOGY (2003)

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Review Chemistry, Medicinal

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MEDICINAL RESEARCH REVIEWS (2002)

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Article Biochemistry & Molecular Biology

Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes

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MOLECULAR MICROBIOLOGY (2001)

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Article Multidisciplinary Sciences

Global differential gene expression in response to growth temperature alteration in group A Streptococcus

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Review Cell Biology

Mechanisms of epithelial fusion and repair

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NATURE CELL BIOLOGY (2001)

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Review Chemistry, Medicinal

Bacterial proteases: current therapeutic use and future prospects for the development of new antibiotics

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EXPERT OPINION ON THERAPEUTIC PATENTS (2001)

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