期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 469, 期 -, 页码 194-201出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2015.01.022
关键词
Wound dressing; Electrospinning; Nanofiber; Antibacterial; Tissue engineering
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2013-012911, 2013R1A2A2A04015484]
- Fusion Technology Development Project - Korean Small and Medium Business Administration [S2175879]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S2175879] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Electrospun nanofibrous mat for wound dressing application was successfully prepared from poly (6caprolactone) (PCL), cellulose acetate (CA) and dextran blend solution. Incorporation of small amount of tetracycline hydrochloride (TCH), an antibacterial drug, improved the cell proliferation, enhanced blood clotting ability and cell attachment as well as antimicrobial activity of the composite mat. The composite mats were characterized by SEM, FTIR and TGA analysis. In order to evaluate the cytocompatibility and cell behavior of the composite scaffolds, fibroblast cells were seeded on the matrix. Results demonstrated that the incorporation of dextran and drug strongly enhanced the adhesion and proliferation of the cells on the composite nanofibers. The antimicrobial activity of the composite was studied by zone inhibition against Gram-positive and Gram-negative bacteria and the result indicates high antibacterial activity. Therefore, as synthesized composite fiber have decent characteristics for wound dressing and skin engineering applications. (C) 2015 Elsevier B.V. All rights reserved.
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