期刊
ANALYTICAL CHEMISTRY
卷 95, 期 4, 页码 2504-2512出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.2c04816
关键词
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This study introduces a facile microplatform for generating 3D tumors and evaluating combinatorial drug screening. The high stability and applicability of the tumor-on-a-chip system are demonstrated, offering potential applications in tumor biology, pharmacology, and tissue microengineering.
The establishment and application of a generalizable three-dimensional (3D) tumor device for high-throughput screening plays an important role in drug discovery and cancer therapeutics. In this study, we introduce a facile microplatform for considerable 3D tumor generation and combinatorial drug screening evaluation. High fidelity of chip fabrication was achieved depending on the simple and well-improved microcontact printing. We demonstrated the high stability and repeatability of the established tumor-on-a-chip system for controllable and massive production of 3D tumors with high size uniformity. Importantly, we accomplished the screening-like chemotherapy investigation involving individual and combinatorial drugs and validated the high accessibility and applicability of the system in 3D tumor-based manipulation and analysis on a large scale. This achievement in tumor-on-a-chip has potential applications in plenty of biomedical fields such as tumor biology, pharmacology, and tissue microengineering. It offers an insight into the development of the popularized microplatform with easy-to-fabricate and easy-tooperate properties for cancer exploration and therapy.
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