Hollow Cu2-xSe-based nanocatalysts for combined photothermal and chemodynamic therapy in the second near-infrared window

Chemodynamic therapy (CDT) and photothermal therapy (PTT) have gained popularity due to their non-invasive characteristics and satisfying therapeutic expectations. A Cu-based nanomaterial serving as a Fenton-like nanocatalyst for CDT together with a photothermal agent for simultaneous PTT seems to be a powerful strategy. In this work, the morphological effect of Cu2-xSe nanoparticles on CDT and PTT was systematically investigated. In particular, the hollow octahedral Cu2-xSe nanoparticles exhibited higher photothermal and chemodynamic performance than that of spherical or cubic Cu2-xSe nanoparticles in the second near-infrared (NIR-II) window. In addition, the octahedral Cu2-xSe nanoparticles were further loaded with the autophagy inhibitor chloroquine (CQ) and connected with the targeting neuropeptide Y ligand, and shown to work as a novel therapeutic platform (Cu2-xSe@CQ@NPY), holding an immense potential to achieve synergetic enhancement of CDT/PTT with a positive therapeutic outcome for breast cancer.

Automated summary

This study investigates the morphological effect of Cu2-xSe nanoparticles on chemodynamic therapy (CDT) and photothermal therapy (PTT). Hollow octahedral Cu2-xSe nanoparticles showed better photothermal and chemodynamic performance in the NIR-II window. Additionally, a therapeutic platform (Cu2-xSe@CQ@NPY) was developed, which holds great potential for achieving synergistic enhancement of CDT/PTT in breast cancer treatment.