Mechanism and application of 3D-printed degradable bioceramic scaffolds for bone repair

Article Materials Science, Multidisciplinary

Characterization of hydroxyapatite powders and selective laser sintering of its composite with polyamide

Amirhossein Alahnoori et al.

Summary: This study successfully fabricated a porous part using indirect selective laser sintering (SLS) with natural hydroxyapatite (HA) and polyamide 12 (PA12). The results showed that bovine bone can be an excellent source for producing HA.

MATERIALS CHEMISTRY AND PHYSICS (2023)

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Review Biotechnology & Applied Microbiology

Breaking the resolution limits of 3D bioprinting future opportunities and present challenges

Tommaso Zandrini et al.

Summary: Bioprinting aims to create 3D structures with embedded cells that mimic the native extracellular matrix, but limited spatial resolution has been a hindrance. This opinion article reviews the emergence and discusses the most promising high-definition (HD) bioprinting techniques to overcome this limitation and enable the fabrication of more complex tissue and organ models in tissue engineering.

TRENDS IN BIOTECHNOLOGY (2023)

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Article Engineering, Biomedical

Degradation of 3D-printed magnesium phosphate ceramics in vitro and a prognosis on their bone regeneration potential

Gefel Eugen et al.

Summary: This article investigates the bioresorption and regenerative effects of calcium phosphate and magnesium phosphate-based bone graft materials. The results show that magnesium phosphate-based materials have better bioresorbability and bone regeneration effects, with complete degradation expected within 1.5-3.1 years.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Nano-calcium silicate mineralized fish scale scaffolds for enhancing tendon-bone healing

Fei Han et al.

Summary: This study utilized natural fish scale modified by calcium silicate nanoparticles as a new biomaterial to overcome the challenge of tendon-bone healing. The fish scale-based scaffold demonstrated excellent tensile strength and bioactivity, making it a promising candidate for clinical tendon repair. The research also showed that the biomaterial played a key role in tendon-bone interface regeneration and biomechanical function.

BIOACTIVE MATERIALS (2023)

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Review Engineering, Biomedical

Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?

Oznur Demir-Oguz et al.

Summary: Calcium phosphate bone cements (CPCs) have valuable properties such as bioactivity, osteoconductivity, injectability, and moldability, but their low mechanical performance limits their clinical application. Adding bioactive glasses (BGs) as a secondary powder phase can improve the injectable properties of CPCs and enhance the degradation rate, in vitro osteogenic differentiation, cell response, and tissue-material interaction.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Bone without borders - Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope

Furqan A. Shah et al.

Summary: Calcium phosphates (CaP) are important biomaterials for bone regeneration. This study demonstrates how a multi-component CaP formulation can guide bone formation beyond the normal physiological range. The study shows successful bone formation and remodeling in sheep models using this CaP formulation, and the presence of woven bone and vascularized lamellar bone in the pores of the CaP material.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Biological response of 3D-printed β-tricalcium phosphate bioceramic scaffolds with the hollow tube structure

Yuchen Tian et al.

Summary: Repairing critical-size bone defects is a challenging task in clinical practice, and early-stage vascularization is crucial for bone regeneration. This study utilized 3D printing technology to create beta-tricalcium phosphate bioceramic scaffolds with a hollow tube structure, which demonstrated superior osteogenic and angiogenic properties compared to solid scaffolds. These scaffolds have great potential for the treatment of critical-size bone defects.

BIOMEDICAL MATERIALS (2023)

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Review Materials Science, Biomaterials

Recent Advances in Additive Manufacturing, Applications and Challenges for Dentistry: A Review

Swati Chaudhary et al.

Summary: Technological advancement in dentistry has led to new opportunities for professionals and laboratory programmers. The emergence of digitalization and 3D printing has allowed for the creation of block pieces by adding material layer-by-layer. This article summarizes the recent developments and challenges of additive manufacturing techniques in dentistry, focusing on 3D printing advancements and its advantages and disadvantages.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2023)

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Article Engineering, Biomedical

A bioactive glass functional hydrogel enhances bone augmentation via synergistic angiogenesis, self-swelling and osteogenesis

Fujian Zhao et al.

Summary: This study utilized double-crosslinked gelatin-hyaluronic acid hydrogels with self-swelling properties and dispersed niobium doped bioactive glasses to improve the mechanical properties of the hydrogel. The composite hydrogel synergistically promoted angiogenesis and increased bone augmentation in the early stage of implantation, and also significantly promoted new bone formation in the late stage.

BIOACTIVE MATERIALS (2023)

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Review Engineering, Biomedical

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Sayan Deb Dutta et al.

Summary: Macrophage-assisted immunomodulation is a strategy used in tissue engineering to determine the fate of healing or inflammation by the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells. This review focuses on the necessity of 3D immunomodulatory scaffolds and nanomaterials, their interaction with macrophages, and the challenges and future necessity of 3D bioprinted immunomodulatory materials for tissue engineering.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Biomaterial-induced pathway modulation for bone regeneration

Steven Vermeulen et al.

Summary: Embryogenic developmental processes involve a tightly controlled regulation between mechanical forces and biochemical cues. Understanding the pathways that govern bone regeneration is crucial for the development of effective regenerative therapies. However, current biochemical stimuli are often insufficient due to the lack of an appropriate mechanical environment. Therefore, further research on biomaterials and their effects on bone regeneration pathways is needed to inspire the development of more effective therapies.

BIOMATERIALS (2022)

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Article Materials Science, Ceramics

Digital light processing porous TPMS structural HA & akermanite bioceramics with optimized performance for cancellous bone repair

Shuai-Bin Hua et al.

Summary: Amorphous bioglass has been used to improve the bioactivity of HA, but the crystallization of bioglass during sintering has made it difficult to tailor the properties of HA bioceramics. In this study, TPMS structural HA ceramics doped with akermanite showed increased porosity, bioactivity, and mechanical strength. The substitution of Ca2+ ions by Mg2+ ions from akermanite led to the decomposition of HA into beta-TCP, increasing porosity and enhancing mechanical strength. By optimizing the content of akermanite, bioceramics exhibited high porosity, appropriate compressive strength, enhanced in vitro bioactivity, and good biocompatibility, suitable for repairing cancellous bone defects.

CERAMICS INTERNATIONAL (2022)

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Article Engineering, Multidisciplinary

Lithium-containing bioactive glasses enhanced 3D-printed PLGA scaffolds for bone regeneration in diabetes

Yu Chen et al.

Summary: The research shows that lithium-containing biomaterials Li-MBG can reverse the inhibitory effects of high glucose on stem cell proliferation, migration, and osteogenic differentiation, promoting bone formation by activating signaling pathways. Li-MBG/PLGA composite scaffolds demonstrate good effectiveness in repairing skull defects in DM mice.

COMPOSITES PART B-ENGINEERING (2022)

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Article Biochemistry & Molecular Biology

3D Printed Poly(ε-caprolactone)/Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties

Sara Biscaia et al.

Summary: In the field of bone tissue engineering, polycaprolactone/hydroxyapatite scaffolds have been identified as promising candidates. This study investigates the scaffolds prepared through two blending methods and explores their chemical, thermal, morphological, and mechanical characteristics. The results suggest that the scaffolds produced by melt blending exhibit superior mechanical properties and osteogenic activity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Surgery

Zygoma Augmentation With 3D Printed Bioactive Glass-Ceramic Implant

Hyunmi Jo et al.

Summary: Zygoma, located in the middle third of the face, has a significant impact on facial impression. CaO-SiO2-P2O5-B2O3 glass-ceramics (BGS-7) has been reported as a nonresorbable bone grafting material with bioactivity and radiopacity. With the development of CAD-CAM technology, patient-specific designs of BGS-7 can be manufactured. A clinical case showed that 3D printed BGS-7 implant remained in place and bony fusion occurred, indicating its effectiveness and safety for zygoma bone defects.

JOURNAL OF CRANIOFACIAL SURGERY (2022)

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Article Cell & Tissue Engineering

3D printing of poly(butylene adipate-co-terephthalate) (PBAT)/niobium containing bioactive glasses (BAGNb) scaffolds: Characterization of composites, in vitro bioactivity, and in vivo bone repair

Lucienne Miranda Ulbrich et al.

Summary: This study produced PBAT/BAGNb composite scaffolds using FDM printing and evaluated their physicochemical and biological properties in vitro and in vivo. The scaffolds showed high porosity and cell mineralization ability. In vivo results indicated that PBAT/BAGNb group exhibited good new bone formation.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2022)

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Article Chemistry, Physical

The Fabrication and Characterization of BaTiO3 Piezoceramics Using SLA 3D Printing at 465 nm Wavelength

Andrey Smirnov et al.

Summary: This study demonstrates the additive manufacturing of BaTiO3 ceramics through stereolithography 3D printing at 465 nm wavelength. Different paste compositions with varied initial micron-sized powders were explored for 3D printing, and the photopolymerization depth was evaluated. The microstructure and properties of the 3D-printed samples were characterized and compared with those of ceramics fabricated through a conventional die semi-drying pressing method.

MATERIALS (2022)

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Article Chemistry, Physical

Effect of Hydroxyapatite Nanoparticles and Nitrogen Plasma Treatment on Osteoblast Biological Behaviors of 3D-Printed HDPE Scaffold for Bone Tissue Regeneration Applications

Hyunchul Park et al.

Summary: This study investigated the effects of adding nano-hydroxyapatite (n-HAp) particles and treating with nitrogen plasma on the biological response of preosteoblast cells. The results showed that the incorporation of n-HAp particles and N-2 plasma surface treatment improved the biological responses of preosteoblast cells in the HDPE scaffolds.

MATERIALS (2022)

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Article Materials Science, Multidisciplinary

In situ magnesium phosphate/polycaprolactone 3D-printed scaffold induce bone regeneration in rabbit maxillofacial bone defect model

Bocheng Lei et al.

Summary: The PCL#20MgP scaffold prepared by 3D printing technology has strong ability to promote osteogenic differentiation and bone formation, which is suitable for the repair of maxillofacial bone defects.

MATERIALS & DESIGN (2022)

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Article Engineering, Biomedical

Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels

Junxiang Hao et al.

Summary: This study proposes a novel strategy of bone regeneration units (BRUs) by combining decalcified bone matrix (DBM) and vascular endothelial growth factor (VEGF) in microgels, creating an accurate biomimetic osteoinductive microenvironment. The physicochemical properties of microgels can be controlled, promoting adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro and reliable bone regeneration in vivo. By integrating BRUs with a DBM framework, bone tissue with desired 3D morphology is successfully regenerated and large-sized bone defects are effectively repaired.

BIOACTIVE MATERIALS (2022)

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Article Materials Science, Ceramics

Fabrication of a zirconia/calcium silicate composite scaffold based on digital light processing

Zhijing He et al.

Summary: In this study, a porous ZrO2/CS composite ceramic scaffold was successfully formed using digital light processing technology. The addition of CS was found to improve the mechanical properties and cell activity of the scaffold, and the degradation process promoted the integration of the scaffold with living bone.

CERAMICS INTERNATIONAL (2022)

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Article Materials Science, Ceramics

3D printing of polycaprolactone/bioactive glass composite scaffolds for in situ bone repair

Chenglong Wang et al.

Summary: This study used bioactive glass to improve the bone repair scaffold material made of polycaprolactone (PCL) and found that increasing the content of bioactive glass can enhance the hydrophilicity of the scaffold, improve cell adhesion and proliferation, and promote bone repair. The results of the study suggest that PCL scaffolds containing 20% bioactive glass have great potential for clinical bone repair.

CERAMICS INTERNATIONAL (2022)

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Article Dentistry, Oral Surgery & Medicine

Three-dimensional printing of clinical scale and personalized calcium phosphate scaffolds for alveolar bone reconstruction

Margaret Anderson et al.

Summary: This study aimed to devise a protocol for fabricating customized clinical scale and patient-specific bioceramic scaffolds for reconstructing large alveolar bone defects. The study successfully developed a clinically feasible laboratory workflow using CBCT imaging to design and 3D print defect-specific bioceramic scaffolds. OsteoinkTM was identified as a biocompatible material for precision-fit alveolar bone reconstructive procedures.

DENTAL MATERIALS (2022)

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Article Dentistry, Oral Surgery & Medicine

Clinical evaluation of 3D printed nano- porous hydroxyapatite bone graft for alveolar ridge preservation: A randomized controlled trial

Pennapa Kijartorn et al.

Summary: This study evaluated the clinical efficacy of 3D printed nano-porous hydroxyapatite (3DP HA) compared to nano-crystalline bone graft (NanoBone (R)) in alveolar ridge preservation. The results showed less soft tissue surface resorption in the test group but no significant difference in alveolar bone resorption between the two groups after four months.

JOURNAL OF DENTAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Beta-tricalcium phosphate enhanced mechanical and biological properties of 3D-printed polyhydroxyalkanoates scaffold for bone tissue engineering

Xiangling Ye et al.

Summary: In this study, 3D-printed PHA/β-TCP scaffolds were successfully prepared by adding beta-TCP to PHA and using a twin-screw extruder and fused deposition modeling technique. The scaffolds exhibited good mechanical properties and biocompatibility, and promoted cell proliferation, adhesion, and migration, as well as enhanced osteogenesis-related gene expression.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Surgery

Clinical Application of Three-Dimensional Printing of Polycaprolactone/Beta-Tricalcium Phosphate Implants for Cranial Reconstruction

Hojin Park et al.

Summary: This study presents the use of patient-specific PCL/ss-TCP implants for cranioplasty. The results show improved symmetry and a favorable cosmetic outcome after 6 months of follow-up, with no postoperative foreign body reaction.

JOURNAL OF CRANIOFACIAL SURGERY (2022)

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Article Dermatology

A multi-centre, single-blinded randomised controlled clinical trial evaluating the effect of resorbable glass fibre matrix in the treatment of diabetic foot ulcers

David G. Armstrong et al.

Summary: This study compared the use of a unique resorbable glass microfiber matrix with standard care for diabetic foot ulcers, showing significantly improved wound healing with the addition of the matrix. No adverse events related to treatment were reported in the study.

INTERNATIONAL WOUND JOURNAL (2022)

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Article Materials Science, Multidisciplinary

Upgrading a Consumer Stereolithographic 3D Printer to Produce a Physiologically Relevant Model with Human Liver Cancer Organoids

Louise Breideband et al.

Summary: This article introduces an open-source device based on a commercially available 3D stereolithography printer, which is used for bioprinting research. The device can produce complex structures and maintain cell viability to replicate physiological features of tissues. Detailed documentation and performance analysis make it easy for other labs to adopt and customize. Additionally, multiple modified bioprinters can be operated simultaneously due to low cost, allowing for parallelized tissue production.

ADVANCED MATERIALS TECHNOLOGIES (2022)

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Article Materials Science, Multidisciplinary

Inkjet-printed flexible sensors: From function materials, manufacture process, and applications perspective

Xuepei Wang et al.

Summary: This paper reviews the recent research progress on the preparation of flexible sensors by inkjet printing, including key functional materials, fabrication processes, and applications. The key fabrication techniques, characterization techniques, and optimization methods are highlighted. The opportunities and challenges of inkjet printed flexible sensors are discussed in comparison with traditional rigid sensors.

MATERIALS TODAY COMMUNICATIONS (2022)

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Article Engineering, Biomedical

3D-printed bioactive ceramic scaffolds with biomimetic micro/nano-HAp surfaces mediated cell fate and promoted bone augmentation of the bone-implant interface in vivo

Xiao Liu et al.

Summary: This study utilized a facile and novel method to construct a uniform hydroxyapatite (HAp) surface layer on composite ceramics, and combined with 3D printing technology to fabricate biomimetic hierarchical structure scaffolds. The obtained HAp surface layer favored cell adhesion, upregulated cellular differentiation and gene expression, and promoted capillary formation, bone augmentation, and new bone matrix formation in vivo.

BIOACTIVE MATERIALS (2022)

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Review Metallurgy & Metallurgical Engineering

Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing

Ning Wang et al.

Summary: This review provides an account of the specific mechanisms by which magnesium alloys promote bone healing, including immunomodulation, angiogenesis, osteogenesis, and regulation of osteoclast function. It highlights the regulation of magnesium alloys on various cells involved in bone healing and summarizes the signaling pathways involved. This review also supports the future investigation and application of magnesium alloys in orthopedic fields.

JOURNAL OF MAGNESIUM AND ALLOYS (2022)

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Review Engineering, Biomedical

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Chaoqian Zhao et al.

Summary: Bioceramic-based scaffolds play a crucial role in bone defect repair and antibacterial function. Various antibacterial strategies have been developed for these scaffolds, leading to significant advancements in the field.

BIOACTIVE MATERIALS (2022)

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Article Biotechnology & Applied Microbiology

3D printing polylactic acid polymer-bioactive glass loaded with bone cement for bone defect in weight-bearing area

Yurun Ding et al.

Summary: The treatment of bone defects in weight-bearing areas requires filling materials that can provide both strong mechanical support and promote bone regeneration. In this study, a 3D printing frame-filling structure was introduced, where the frame provided long-term fixation and the bone cement provided immediate fixation, while the degradation of bioactive glass promoted bone metabolism.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Engineering, Chemical

Laser powder bed fusion of ultra-high-molecular-weight polyethylene/hydroxyapatite composites for bone tissue engineering

Henrique Schappo et al.

Summary: Laser powder bed fusion, also known as selective laser sintering (SLS) or selective laser melting (SLM), is a valuable manufacturing technique for implantable devices. Polymeric/ceramic biocomposites are favorable materials for fabricating customized implants, and preliminary in vitro assays demonstrate their biocompatibility. However, improvements in mechanical properties are needed.

POWDER TECHNOLOGY (2022)

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Article Engineering, Manufacturing

Microstructures and mechanical properties of biphasic calcium phosphate bioceramics fabricated by SLA 3D printing

Dong Dong et al.

Summary: The efficient sintering procedure is crucial for determining the microstructures and mechanical properties of BCP bioceramics fabricated by SLA 3D printing. Optimized sintering temperature of 1250 degrees C for 2 h resulted in BCP bioceramics with uniform shrinkage and mechanical properties comparable to human cortical bone.

JOURNAL OF MANUFACTURING PROCESSES (2022)

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Review Materials Science, Biomaterials

Engineering biomaterials to 3D-print scaffolds for bone regeneration: practical and theoretical consideration

Mohammad Aftab Alam Ansari et al.

Summary: More than 2 million bone grafting procedures are performed annually in the US, but repairing large segmental bone defects remains a challenge. Advanced biomaterials are being designed to mimic bone composition, with 3D printing emerging as a popular manufacturing technique for engineered bone grafts.

BIOMATERIALS SCIENCE (2022)

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Article Materials Science, Biomaterials

Preparation and characterization of novel lithium magnesium phosphate bioceramic scaffolds facilitating bone generation

Fupo He et al.

Summary: This study synthesized lithium magnesium phosphate biomaterials and fabricated bioceramic blocks and scaffolds. The lithium magnesium phosphate bioceramics showed lower porosity, higher compressive strength, and promoted cellular proliferation, osteogenic differentiation, and angiogenic activity in vitro. In vivo experiments demonstrated that the Li2Mg2(PO4)(2) bioceramic scaffolds efficiently promoted bone regeneration in rats.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Chemistry, Multidisciplinary

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Charlotte Garot et al.

Summary: This paper reviews the state-of-the-art materials and AM techniques used in the fabrication of 3D-printed bone scaffolds in bone tissue engineering. The advantages and drawbacks of these materials and techniques are highlighted, with specific criteria for material selection identified. Different combinations of materials and AM techniques are found to be most relevant for specific clinical applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article

Clinical and radiographic outcomes using third-generation bioactive glass as a bone graft substitute for multi-level anterior cervical discectomy and fusion—a retrospective case series study

Gilberto Gomez et al.

Journal of Spine Surgery (2021)

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Article Engineering, Biomedical

Beta-tricalcium phosphate promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells through macrophages

Mengting Zheng et al.

Summary: The study revealed that beta-TCP enhances osteogenic differentiation of BMSCs by inducing macrophage polarization and regulating the Wnt signaling pathway. Macrophages exposed to beta-TCP shifted to the M2 phenotype and exhibited more significant immune responses. This highlights the therapeutic potential of beta-TCP for bone healing through its osteoimmunomodulatory properties.

BIOMEDICAL MATERIALS (2021)

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Article Engineering, Biomedical

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

Hunter Newman et al.

Summary: Impaired bone healing affects 5-10% of cases after injury, with timely resolution of inflammation being crucial for normal healing. Modulating the initial inflammatory phase and promoting its resolution can create a pro-regenerative environment for bone regeneration.

BIOMATERIALS (2021)

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Article Materials Science, Ceramics

Fabrication and properties of 3D printed zirconia scaffold coated with calcium silicate/hydroxyapatite

Hanxu Zhang et al.

Summary: In this study, porous zirconia scaffolds were coated with calcium silicate and hydroxyapatite using 3D printing technology to improve biological activity and mechanical properties. The coating material effectively filled the pores and increased compressive strength. Higher calcium silicate content in the coating increased degradation rate and showed good cytocompatibility with cell proliferation and differentiation. Coated scaffolds have potential applications in bone repair.

CERAMICS INTERNATIONAL (2021)

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Article Engineering, Multidisciplinary

3D printing of PLA/n-HA composite scaffolds with customized mechanical properties and biological functions for bone tissue engineering

Wenzhao Wang et al.

Summary: This study utilized 3D printing technology to fabricate composite scaffolds of PLA and n-HA, and demonstrated their potential for large bone defect repair through biocompatibility and in vivo implantation tests.

COMPOSITES PART B-ENGINEERING (2021)

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Article Materials Science, Biomaterials

Biphasic ceramic bone graft with biphasic degradation rates

Hao-Yu Chang et al.

Summary: The study reports the characteristics of a novel biphasic bone graft composed of calcium sulfate (CS) and hydroxyapatite (HA) with two degradation rates. Most of the bone graft degraded after 13 weeks of implantation, replaced by trabecular bone and vascular tissue at the implant site. The biphasic bone graft is unique for its burst of calcium ions at the beginning and its stable porous structure ideal for new bone formation and vascularization.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

A comparison of the degradation behaviour of 3D printed PDLGA scaffolds incorporating bioglass or biosilica

R. Han et al.

Summary: The study investigated the dissolution behavior of natural biosilica incorporated into PDLGA scaffolds through extrusion and additive manufacturing. Results showed an exponential increase in the release rate of Si4+ ions from diatom-PDLGA scaffolds over time, with the scaffolds maintaining higher compressive strength and less degradation compared to pure PDLGA or 5 wt% Bioglass scaffolds, making them more suitable for bone repair.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Polymer Science

Bioactive glass with biocompatible polymers for bone applications

Janhavi Sonatkar et al.

Summary: Bioactive glasses have been traditionally used for permeating and repairing bone defects, with 45S5 Bio glass being a prime artificial material developed by Larry Hench. These materials have exceptional biocompatibility and can form a HA coat in the body. Various synthesis techniques have been developed for bioactive glasses containing biocompatible polymers, aiming to review the modern evolution of glass for bone regeneration. These glasses can connect to osseous matter and restore new bone growth over time, ultimately restoring the ailing or defective bone to its original condition and function.

EUROPEAN POLYMER JOURNAL (2021)

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Article Materials Science, Multidisciplinary

Stereolithography printing of bone scaffolds using biofunctional calcium phosphate nanoparticles

Ihsan UIIah et al.

Summary: Calcium phosphate (CaP) is widely used for bone defect repair due to its good biocompatibility and osteoconductivity, and additive manufacturing of CaP bioceramics has recently attracted great attention. The study found that biofunctional elements such as magnesium can promote the formation of whitlockite-type calcium phosphate from amorphous calcium phosphate precursors. Gyroid scaffolds with bionic structures fabricated from these nanoparticles may serve as biofunctional scaffolds for bone repair.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2021)

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Article Engineering, Biomedical

Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization

Chong Wang et al.

Summary: 3D printing is increasingly used to create advanced bone tissue engineering scaffolds with biomimetic structures and matched mechanical strengths for improved bone regeneration. Customized scaffolds were produced using cryogenic 3D printing of beta-tricalcium phosphate and osteogenic peptide inks, and coated with angiogenic peptide hydrogel to enhance vascularization. The scaffolds had a hierarchically porous structure similar to human cancellous bone and showed high viability for both endothelial cells and mesenchymal stem cells. Improved in vitro migration and angiogenesis were observed for scaffolds with angiogenic peptide, while enhanced osteogenic differentiation was seen in scaffolds containing osteogenic peptide. In vivo, scaffolds with both peptides showed increased angiogenesis and new bone formation.

BIOACTIVE MATERIALS (2021)

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Review Chemistry, Analytical

Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering

Shebin Tharakan et al.

Summary: Bioprinting stem cells into 3D scaffolds offers great potential in regenerative medicine, bone tissue engineering, and biosensor manufacturing, impacting cellular behavior and differentiation. Different printing methods have varying effects on stem cell viability, proliferation, and differentiation potential. The use of suitable biomaterials and printing methods can enhance osteogenesis and promote advancements in bone tissue engineering.

SENSORS (2021)

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Article Materials Science, Multidisciplinary

3D printed bone tissue regenerative PLA/HA scaffolds with comprehensive performance optimizations

Boqing Zhang et al.

Summary: This study successfully combined PLLH/nHA composite with FDM technology to prepare porous bone repair scaffolds. The scaffolds showed good printing smoothness and accuracy, suitable mechanical properties, and good osteogenic properties.

MATERIALS & DESIGN (2021)

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Article Engineering, Biomedical

Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

Jie Shen et al.

Summary: The study examines the impact of magnesium ions on tissue microenvironment on bone regeneration, showing that moderate magnesium ion content promotes bone formation while absence or excessive magnesium ions inhibit it. The migration of magnesium ions plays a crucial role in bone regeneration.

BIOACTIVE MATERIALS (2021)

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Review Pharmacology & Pharmacy

Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration

Zhen Wang et al.

Summary: Bone regenerative engineering encompasses scaffold design and applications based on electrospinning and 3D bioprinting technologies, aiming to achieve bone tissue regeneration. Electrospun nanofibrous scaffolds and 3D bioprinted scaffolds play crucial roles in bone regeneration, with promising prospects for future development.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Materials Science, Multidisciplinary

3D printed tricalcium phosphate-bioglass scaffold with gyroid structure enhance bone ingrowth in challenging bone defect treatment

Hao Zhu et al.

Summary: Ceramic scaffolds have been used in bone defect treatment for a long time. In this study, a TCP/BG scaffold with gyroid structure was successfully manufactured, showing potential to effectively induce bone ingrowth and integration while maintaining the natural trabecular structure.

APPLIED MATERIALS TODAY (2021)

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Article Engineering, Biomedical

Calcium phosphate-based materials regulate osteoclast-mediated osseointegration

Xiaogang Wang et al.

Summary: Calcium phosphate-based materials, commonly used in bone graft substitutes, play a crucial role in bone healing. Recent studies have shown that osteoclast behaviors can greatly influence osteogenesis, with an appropriate Ca/P ratio promoting osteoclast differentiation and bone healing. This suggests the potential of manipulating osteoclast-mediated osteogenesis for improving osseointegration in materials.

BIOACTIVE MATERIALS (2021)

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Review Polymer Science

State-of-Art of Standard and Innovative Materials Used in Cranioplasty

Valentina Siracusa et al.

Summary: Cranioplasty is a surgical technology used to repair various head injuries, and different materials such as biological or synthetic substitutes are employed. Selection of the best material and operation procedure remains controversial, with a focus on improving mechanical properties, bioactivity, and reducing costs. Polymer materials like polymethylmethacrylate and polyetheretherketone are particularly promising for their biocompatibility, rigidity, and toughness.

POLYMERS (2021)

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Article Biotechnology & Applied Microbiology

Case Report: Histological and Histomorphometrical Results of a 3-D Printed Biphasic Calcium Phosphate Ceramic 7 Years After Insertion in a Human Maxillary Alveolar Ridge

Carlo Mangano et al.

Summary: The study evaluated a case of bone regeneration using a 30%HA-60%beta-TCP BCP 3D-printed scaffold, with clinical and histological results after 7 years, showing the effectiveness of BCP scaffolds for bone regeneration. Results demonstrated complete integration and preservation of correct bone tissue structure with the 3D printed scaffold.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Engineering, Biomedical

Immunomodulatory bioactive glasses for tissue regeneration

Kai Zheng et al.

Summary: The regulatory functions of immune response in tissue regeneration, ways to modulate immune cell responses (especially macrophages), and the potential of bioactive glasses in bone regeneration and wound healing have been recognized. Understanding the immunomodulatory effects of BGs and the interactions with immune cells are crucial for enhancing tissue regeneration. Emerging research focuses on harnessing macrophage responses through active ions, surface functionalization, and controlled release of immunomodulatory agents for improved tissue regeneration.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration

Wei Qiao et al.

Summary: The study demonstrates that different phenotypes of macrophages play different roles in regulating bone tissue regeneration, and sequential activation of heterogeneous macrophages triggered by metal ions can effectively promote bone healing.

BIOMATERIALS (2021)

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Review Cell Biology

The role of Ca2+/Calcineurin/NFAT signalling pathway in osteoblastogenesis

Ranyue Ren et al.

Summary: The process of bone remodelling is closely related to bone health, with the Ca2+/Calcineurin/NFAT signalling pathway playing a key role. Excessive activation of osteoclasts or lack of function of osteoblasts can lead to the occurrence and development of various bone-related diseases.

CELL PROLIFERATION (2021)

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Article Critical Care Medicine

Bioactive glass S53P4 to fill-up large cavitary bone defect after acute and chronic osteomyelitis treated with antibiotic-loaded cement beads: A prospective case series with a minimum 2-year follow-up

Kodi Edson Kojima et al.

Summary: The study evaluated the clinical and radiographic outcomes of patients treated with antibiotics-loaded cement beads followed by bone defects filling using bioactive glass in the management of osteomyelitis. All patients showed favorable evolution after bioactive glass procedure, with no need for reoperation or relevant wound problems.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2021)

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Article Cell Biology

Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation

Beilei Liang et al.

Summary: After dental implantation, M phi s dynamically adapt their phenotypes and play a key role in coordinating interactions with bone cells. While M1 and M2 M phi s have different functions in bone remodelling, it is important to control immune strategies within proper ranges for optimal tissue engineering implants.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

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Article Materials Science, Multidisciplinary

A novel snail-inspired bionic design of titanium with strontium-substituted hydroxyapatite coating for promoting osseointegration

Zhen Geng et al.

Summary: The study fabricated titanium-based implants with a bionic micro/nano-structure and SrHA coating, promoting osteoblast growth and inhibiting osteoclast generation. The rabbit model experiment confirmed its benefit for mechanical interlocking between bone and implant, suggesting a potential application in the orthopedics field.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2021)

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Article Materials Science, Ceramics

Optimized preceramic polymer for 3D structured ceramics via fused deposition modeling

Lianzhong Zhao et al.

Summary: The utilization of a small amount of thermoplastic polymer in preceramic polymers improves formability in additive manufacturing of 3D structured ceramics, enhancing compatibility and homogeneity in the mixture. This strategy is not only effective for SiC ceramics, but also applicable to a wide range of ceramic systems with appropriate precursors.

JOURNAL OF THE EUROPEAN CERAMIC SOCIETY (2021)

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Article Engineering, Biomedical

Investigation of the mechanical properties of a bony scaffold for comminuted distal radial fractures: Addition of akermanite nanoparticles and using a freeze-drying technique

Xinmin Dong et al.

Summary: The fabrication of porous scaffold using synergic methods like 3D printing and freeze-drying technology improves the mechanical strength and biological behavior of bone implants. The combination of bioactive ceramic and polymer in the scaffold provides sufficient mechanical performance and healing properties for orthopedic applications.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

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Article Materials Science, Biomaterials

3D printed PCL/β-TCP cross-scale scaffold with high-precision fiber for providing cell growth and forming bones in the pores

Qifan Wang et al.

Summary: A scaffold with a cross-scale structure of PCL/beta-TCP was designed to promote cell growth and osteogenic differentiation on 3D printing scaffolds, significantly enhancing osteogenic performance. Cells can pass through the pores of the scaffold, gradually covering them, which accelerates bone defect repair.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Chemistry, Physical

Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

Nikhil Kamboj et al.

Summary: This paper introduces a PBSLP technique for bioactive ceramics, including PBSLP process, general requirements and properties of bioactive scaffolds, as well as processing methods for calcium phosphate and calcium silicate ceramics and their composite scaffolds.

MATERIALS (2021)

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Review Polymer Science

3D/4D Printing of Polymers: Fused Deposition Modelling (FDM), Selective Laser Sintering (SLS), and Stereolithography (SLA)

Abishek Kafle et al.

Summary: This article discusses three widely used polymer-based 3D printing processes - FDM, SLS, and SLA, providing a comparative overview of material-process-properties and advanced requirements for 4D printing. It also serves as a guide for selecting suitable print materials and techniques for polymer-based applications, as well as discussing implementation practices towards 4D printing of polymer-based systems.

POLYMERS (2021)

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Article Polymer Science

Bioactivity and Bone Cell Formation with Poly-ε-Caprolactone/Bioceramic 3D Porous Scaffolds

Po-Kai Juan et al.

Summary: This study utilized PCL as an additive, nHA and β-TCP as ceramic powders, and NaCl and (NH4)HCO3 as porogens to fabricate 3D porous scaffolds with excellent mechanical properties and biocompatibility. Results showed that nHA and β-TCP could improve the mechanical properties, enhance the hydrophilic properties, and accelerate the degradation rate of the scaffolds.

POLYMERS (2021)

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Review Materials Science, Multidisciplinary

Current Application of Beta-Tricalcium Phosphate in Bone Repair and Its Mechanism to Regulate Osteogenesis

Haiping Lu et al.

Summary: This review focuses on the application of beta-TCP in large segmental bone loss and bone regeneration, discussing its advantages, limitations, customization methods, and potential applications. Through the exploration of the mechanisms of action of beta-TCP in bone repair and healing, valuable insights are provided for optimizing strategies to promote bone repair and regeneration.

FRONTIERS IN MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application

Wenzhao Wang et al.

Summary: The study successfully manufactured composite scaffolds of PLA and n-HA, demonstrating adequate mechanical strength, appropriate pore size, biocompatibility, and superior osteogenic induction performance compared to pure PLA scaffolds when implanted in a rabbit femoral defect model.

NANOTECHNOLOGY REVIEWS (2021)

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Review Computer Science, Information Systems

Classifications and Applications of Inkjet Printing Technology: A Review

Muhammad Ali Shah et al.

Summary: This study reviews the classifications and applications of inkjet printing technologies, focusing on recent publications. Piezoelectric inkjet printing technology is the main focus due to its reliability and versatility with various inks. The study also discusses challenges and solutions in printing quality, stability, and speed, as well as exploring technologies for producing high-viscosity inkjets.

IEEE ACCESS (2021)

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Article Polymer Science

Optimization of selective laser sintering process conditions using stable sintering region approach

F. Lupone et al.

Summary: The research focuses on optimizing SLS process parameters based on material properties, showing that the best combination of mechanical properties and dimensional accuracy for two polymer-based powders can be achieved by using specific laser energy density values.

EXPRESS POLYMER LETTERS (2021)

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Article Engineering, Biomedical

In vitro and in vivo biocompatibility of calcium-phosphate scaffolds three-dimensional printed by stereolithography for bone regeneration

Laurent Le Guehennec et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Article Cell Biology

Mg2+ in β-TCP/Mg-Zn composite enhances the differentiation of human bone marrow stromal cells into osteoblasts through MAPK-regulated Runx2/Osx

Zhenting Wang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Engineering, Biomedical

Correlations between macrophage polarization and osteoinduction of porous calcium phosphate ceramics

Xuening Chen et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

Development of biodegradable bioactive glass ceramics by DLP printed containing EPCs/BMSCs for bone tissue engineering of rabbit mandible defects

Fangfang Xu et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Photopolymerizable Biomaterials and Light-Based 3D Printing Strategies for Biomedical Applications

Claire Yu et al.

CHEMICAL REVIEWS (2020)

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Article Materials Science, Biomaterials

Stereolithography-Based Additive Manufacturing of High Performance Osteoinductive Calcium Phosphate Ceramics by a Digital Light-Processing System

Yihang Wei et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Materials Science, Ceramics

Factors governing the dimensional accuracy and fracture modes under compression of regular and shifted orthogonal scaffolds

E. B. Montufar et al.

JOURNAL OF THE EUROPEAN CERAMIC SOCIETY (2020)

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Article Engineering, Biomedical

Mechanical properties of nanocomposite biomaterials improved by extrusion during direct ink writing

Dibakar Mondal et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2020)

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Article Materials Science, Biomaterials

Transcription factor 7-like 2 promotes osteogenic differentiation and boron-induced bone repair via lipocalin 2

Chengcheng Yin et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Cell Biology

CaMKII(δ) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway

Da-Zhuang Lu et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)

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Article Materials Science, Multidisciplinary

3D printing of calcium phosphate scaffolds with controlled release o antibacterial functions for jaw bone repair

Huan Sun et al.

MATERIALS & DESIGN (2020)

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Article Multidisciplinary Sciences

Macrophages of diverse phenotypes drive vascularization of engineered tissues

P. L. Graney et al.

SCIENCE ADVANCES (2020)

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Review Materials Science, Ceramics

A review of bioceramic porous scaffolds for hard tissue applications: Effects of structural features

Hossein Jodati et al.

CERAMICS INTERNATIONAL (2020)

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Review Materials Science, Ceramics

Review on calcium silicate-based bioceramics in bone tissue engineering

Palakurthy Srinath et al.

INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Bone Regeneration Capability of 3D Printed Ceramic Scaffolds

Ju-Won Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Engineering, Biomedical

Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway

Xu Cui et al.

BIOACTIVE MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Improved Bone Regeneration in Rabbit Bone Defects Using 3D Printed Composite Scaffolds Functionalized with Osteoinductive Factors

Arun Kumar Teotia et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biochemistry & Molecular Biology

Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation

Seira Hoshikawa et al.

FASEB JOURNAL (2020)

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Article Chemistry, Physical

Investigations on the Processing of Ceramic Filled Inks for 3D InkJet Printing

Dennis Graf et al.

MATERIALS (2020)

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Article Chemistry, Physical

Effect of Cu- and Zn-Doped Bioactive Glasses on the In Vitro Bioactivity, Mechanical and Degradation Behavior of Biodegradable PDLLA Scaffolds

Julian Bejarano et al.

MATERIALS (2020)

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Article Chemistry, Physical

A Clinical Trial to Evaluate the Efficacy and Safety of 3D Printed Bioceramic Implants for the Reconstruction of Zygomatic Bone Defects

Ui-Lyong Lee et al.

MATERIALS (2020)

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Article Biotechnology & Applied Microbiology

The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles

Wang Ruolan et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Materials Science, Multidisciplinary

Bioactive glass scaffold architectures regulate patterning of bone regeneration in vivo

Xiaomeng Shi et al.

APPLIED MATERIALS TODAY (2020)

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Article Engineering, Biomedical

Tough magnesium phosphate-based 3D-printed implants induce bone regeneration in an equine defect model

Nasim Golafshan et al.

BIOMATERIALS (2020)

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Article Engineering, Multidisciplinary

A continuum constitutive model for FDM 3D printed thermoplastics

S. Garzon-Hernandez et al.

COMPOSITES PART B-ENGINEERING (2020)

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Article Engineering, Biomedical

3D Printed Gene-activated Octacalcium Phosphate Implants for Large Bone Defects Engineering

Ilya I. Bozo et al.

INTERNATIONAL JOURNAL OF BIOPRINTING (2020)

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Article Engineering, Biomedical

3D-printed Biomimetic Bioactive Glass Scaffolds for Bone Regeneration in Rat Calvarial Defects

Krishna C. R. Kolan et al.

INTERNATIONAL JOURNAL OF BIOPRINTING (2020)

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Article Biochemistry & Molecular Biology

A novel vehicle-like drug delivery 3D printing scaffold and its applications for a rat femoral bone repairing in vitro and in vivo

Hui Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Article Biochemistry & Molecular Biology

3D Printing of Poly(propylene fumarate) Oligomers: Evaluation of Resin Viscosity, Printing Characteristics and Mechanical Properties

Yuanyuan Luo et al.

BIOMACROMOLECULES (2019)

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Article Dentistry, Oral Surgery & Medicine

Comparison Study of Three Hydroxyapatite-Based Bone Substitutes in a Calvarial Defect Model in Rabbits

Antian Xu et al.

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS (2019)

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Article Materials Science, Multidisciplinary

Bioinspired strong nanocellular composite prepared with magnesium phosphate cement and polyurea aerogel

Yanxiao Li et al.

MATERIALS LETTERS (2019)

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Review Polymer Science

Polymers for additive manufacturing and 4D-printing: Materials, methodologies, and biomedical applications

Carmen M. Gonzalez-Henriquez et al.

PROGRESS IN POLYMER SCIENCE (2019)

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Review Chemistry, Multidisciplinary

Bioceramics: from bone substitutes to nanoparticles for drug delivery

Maria Vallet-Regi

PURE AND APPLIED CHEMISTRY (2019)

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Article Engineering, Biomedical

A Novel Bone Substitute with High Bioactivity, Strength, and Porosity for Repairing Large and Load-Bearing Bone Defects

Jiao Jiao Li et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Nanoscience & Nanotechnology

Three-Dimensional Printed Polylactic Acid Scaffolds Promote Bone-like Matrix Deposition in Vitro

Rayan Fairag et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

A Magnesium-Enriched 3D Culture System that Mimics the Bone Development Microenvironment for Vascularized Bone Regeneration

Sihan Lin et al.

ADVANCED SCIENCE (2019)

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Article Engineering, Biomedical

Optimization of photocrosslinkable resin components and 3D printing process parameters

Antonio J. Guerra et al.

ACTA BIOMATERIALIA (2019)

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Article Materials Science, Ceramics

Additive manufacturing of hydroxyapatite bone scaffolds via digital light processing and in vitro compatibility

Zibo Liu et al.

CERAMICS INTERNATIONAL (2019)

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Review Materials Science, Ceramics

Current advances in bone tissue engineering concerning ceramic and bioglass scaffolds: A review

Renata Guimardes Ribas et al.

CERAMICS INTERNATIONAL (2019)

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Article Orthopedics

Repair of Critical-Sized Long Bone Defects Using Dipyridamole-Augmented 3D-Printed Bioactive Ceramic Scaffolds

Lukasz Witek et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2019)

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Article Oncology

Novel 3D-printed prosthetic composite for reconstruction of massive bone defects in lower extremities after malignant tumor resection

Lu Yajie et al.

JOURNAL OF BONE ONCOLOGY (2019)

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Article Nanoscience & Nanotechnology

Nano-Hydroxyapatite Coating Promotes Porous Calcium Phosphate Ceramic-Induced Osteogenesis Via BMP/Smad Signaling Pathway

Jing Wang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Engineering, Biomedical

Three-dimensional (3D) printed scaffold and material selection for bone repair

Lei Zhang et al.

ACTA BIOMATERIALIA (2019)

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Review Pharmacology & Pharmacy

Photopolymerizable Resins for 3D-Printing Solid-Cured Tissue Engineered Implants

Antonio J. Guerra et al.

CURRENT DRUG TARGETS (2019)

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Review Dentistry, Oral Surgery & Medicine

Applications of 3D printing on craniofacial bone repair: A systematic review

Michael Maroulakos et al.

JOURNAL OF DENTISTRY (2019)

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Article Orthopedics

Autograft, Allograft, and Bone Graft Substitutes: Clinical Evidence and Indications for Use in the Setting of Orthopaedic Trauma Surgery

Paul Baldwin et al.

JOURNAL OF ORTHOPAEDIC TRAUMA (2019)

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Article Dentistry, Oral Surgery & Medicine

Histological and histomorphometric evaluation of hydroxyapatite-based biomaterials in surgically created defects around implants in dogs

Mai S. Attia et al.

JOURNAL OF PERIODONTOLOGY (2019)

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Review Materials Science, Multidisciplinary

A proposed mechanism for material-induced heterotopic ossification

Marc Bohner et al.

MATERIALS TODAY (2019)

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Article Materials Science, Biomaterials

Dose-dependent modulation effects of bioactive glass particles on macrophages and diabetic wound healing

Weihan Xie et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Engineering, Biomedical

3D printed porous PLA/nHA composite scaffolds with enhanced osteogenesis and osteoconductivity in vivo for bone regeneration

Xibao Chen et al.

BIOMEDICAL MATERIALS (2019)

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Review Materials Science, Multidisciplinary

Photopolymerization in 3D Printing

Ali Bagheri et al.

ACS APPLIED POLYMER MATERIALS (2019)

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Review Engineering, Biomedical

Review of bone graft and bone substitutes with an emphasis on fracture surgeries

Hoon-Sang Sohn et al.

BIOMATERIALS RESEARCH (2019)

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Article Engineering, Biomedical

Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure

Joseph B. Vella et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

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Review Cell Biology

The roles of signaling pathways in bone repair and regeneration

Maryam Majidinia et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Article Engineering, Biomedical

3D-printed IFN-γ-loading calcium silicate-β-tricalcium phosphate scaffold sequentially activates M1 and M2 polarization of macrophages to promote vascularization of tissue engineering bone

Tao Li et al.

ACTA BIOMATERIALIA (2018)

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Review Engineering, Biomedical

Magnesium-based bioceramics in orthopedic applications

Maryam Nabiyouni et al.

ACTA BIOMATERIALIA (2018)

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Article Engineering, Biomedical

Enhanced In Vivo Bone and Blood Vessel Formation by Iron Oxide and Silica Doped 3D Printed Tricalcium Phosphate Scaffolds

Susmita Bose et al.

ANNALS OF BIOMEDICAL ENGINEERING (2018)

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Article Chemistry, Physical

Fabricating the nanostructured surfaces of CaSiO3 scaffolds

Cijun Shuai et al.

APPLIED SURFACE SCIENCE (2018)

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Article Engineering, Biomedical

Bone mesenchymal stem cell secretion of sRANKL/OPG/M-CSF in response to macrophage-mediated inflammatory response influences osteogenesis on nanostructured Ti surfaces

Qian-li Ma et al.

BIOMATERIALS (2018)

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Article Chemistry, Applied

Biocompatible silk/calcium silicate/sodium alginate composite scaffolds for bone tissue engineering

Ao Zheng et al.

CARBOHYDRATE POLYMERS (2018)

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Article Materials Science, Ceramics

Effect of print path process on sintering behavior and thermal shock resistance of Al2O3 ceramics fabricated by 3D inkjet-printing

Zijun Peng et al.

CERAMICS INTERNATIONAL (2018)

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Article Biophysics

Stimulation of cell responses and bone ingrowth into macro-microporous implants of nano-bioglass/polyetheretherketone composite and enhanced antibacterial activity by release of hinokitiol

Jue Zhang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Review Biochemistry & Molecular Biology

Natural and synthetic polymersibioceramicsibioactive compounds-mediated cell signalling in bone tissue engineering

S. Harsha Rao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Biochemistry & Molecular Biology

Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment

Lifang Hu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Dentistry, Oral Surgery & Medicine

Comparative study of volumetric changes and trabecular microarchitecture in human maxillary sinus bone augmentation with bioactive glass and autogenous bone graft: a prospective and randomized assessment

R. S. Pereira et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2018)

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Article Dentistry, Oral Surgery & Medicine

Extracellular calcium increases fibroblast growth factor 2 gene expression via extracellular signal-regulated kinase 1/2 and protein kinase A signaling in mouse dental papilla cells

Sousuke Kanaya et al.

JOURNAL OF APPLIED ORAL SCIENCE (2018)

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Article Engineering, Biomedical

Silicate-doped nano-hydroxyapatite/graphene oxide composite reinforced fibrous scaffolds for bone tissue engineering

Ali Deniz Dalgic et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2018)

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Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Article Surgery

Clinical Outcomes of Digital Three-Dimensional Hydroxyapatite in Repairing Calvarial Defects

Hongbo Chen et al.

JOURNAL OF CRANIOFACIAL SURGERY (2018)

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Article Surgery

Three dimensionally printed bioactive ceramic scaffold osseoconduction across critical-sized mandibular defects

Christopher D. Lopez et al.

JOURNAL OF SURGICAL RESEARCH (2018)

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Article Cell Biology

Dicalcium Silicate Induced Proinflammatory Responses through TLR2-Mediated NF-κB and JNK Pathways in the Murine RAW 264.7 Macrophage Cell Line

Shixiang Lai et al.

MEDIATORS OF INFLAMMATION (2018)

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Article Materials Science, Biomaterials

In Vivo Biocompatibility of Zinc-Doped Magnesium Silicate Bio-Ceramics

K. Bavya Devi et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Chemistry, Multidisciplinary

A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair

Pei Feng et al.

ADVANCED SCIENCE (2018)

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Article Materials Science, Biomaterials

In Vivo Biocompatibility of Zinc-Doped Magnesium Silicate Bio-Ceramics

K. Bavya Devi et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Engineering, Biomedical

Osteogenesis by foamed and 3D-printed nanostructured calcium phosphate scaffolds: Effect of pore architecture

Albert Barba et al.

ACTA BIOMATERIALIA (2018)

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Article Engineering, Biomedical

3D-Plotted Beta-Tricalcium Phosphate Scaffolds with Smaller Pore Sizes Improve In Vivo Bone Regeneration and Biomechanical Properties in a Critical-Sized Calvarial Defect Rat Model

Jingjing Diao et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Engineering, Biomedical

Optimization of the configuration of porous bone scaffolds made of Polyamide/Hydroxyapatite composites using Selective Laser Sintering for tissue engineering applications

M. Ramu et al.

BIO-MEDICAL MATERIALS AND ENGINEERING (2018)

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Review Engineering, Biomedical

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Soroosh Derakhshanfar et al.

BIOACTIVE MATERIALS (2018)

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Article Surgery

Regeneration of Cystic Bone Cavities and Bone Defects With Bioactive Glass S53P4 in the Upper and Lower Jaws

Patricia Stoor et al.

JOURNAL OF CRANIOFACIAL SURGERY (2017)

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Article Orthopedics

Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway

Laura Y. Lu et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2017)

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Article Orthopedics

Size Matters: Defining Critical in Bone Defect Size!

Emil H. Schemitsch

JOURNAL OF ORTHOPAEDIC TRAUMA (2017)

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Article Materials Science, Biomaterials

Bioactivity characterization of 45S5 bioglass using TL, OSL and EPR: Comparison with the case of 58S sol-gel bioactive glass

G. S. Polymeris et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Review Engineering, Mechanical

Direct selective laser sintering and melting of ceramics: a review

Swee Leong Sing et al.

RAPID PROTOTYPING JOURNAL (2017)

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Article Cell & Tissue Engineering

Bone Regenerative Medicine in Oral and Maxillofacial Region Using a Three-Dimensional Printer

Atsuhiko Hikita et al.

TISSUE ENGINEERING PART A (2017)

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Review Engineering, Biomedical

Bioinspired Collagen Scaffolds in Cranial Bone Regeneration: From Bedside to Bench

Justine C. Lee et al.

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Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits

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Stereolithography: A new method for processing dental ceramics by additive computer-aided manufacturing

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Surface-enrichment with hydroxyapatite nanoparticles in stereolithography-fabricated composite polymer scaffolds promotes bone repair

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Bone regeneration in 3D printing bioactive ceramic scaffolds with improved tissue/material interface pore architecture in thin-wall bone defect

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Gene Expression Profiling and Molecular Signaling of Various Cells in Response to Tricalcium Silicate Cements: A Systematic Review

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Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway

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Hierarchically porous nagelschmidtite bioceramic-silk scaffolds for bone tissue engineering

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2015)

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Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway

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Effect of Verapamil, a Calcium Channel Blocker, on the Odontogenic Activity of Human Dental Pulp Cells Cultured with Silicate-based Materials

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Mechanical and physical properties of calcium silicate/alumina composite for biomedical engineering applications

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Odontogenic differentiation of human dental pulp cells by calcium silicate materials stimulating via FGFR/ERK signaling pathway

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Polymer-Ceramic Spiral Structured Scaffolds for Bone Tissue Engineering: Effect of Hydroxyapatite Composition on Human Fetal Osteoblasts

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PLOS ONE (2014)

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Review of bioactive glass: From Hench to hybrids

Julian R. Jones

ACTA BIOMATERIALIA (2013)

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Integrin binding and MAPK signal pathways in primary cell responses to surface chemistry of calcium silicate cements

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BIOMATERIALS (2013)

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Processing and characterization of laser sintered hydroxyapatite scaffold for tissue engineering

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BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2013)

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Effects of apatite particle size in two apatite/collagen composites on the osteogenic differentiation profile of osteoblastic cells

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

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A new custom made bioceramic implant for the repair of large and complex craniofacial bone defects

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The enhancement of bone regeneration by a combination of osteoconductivity and osteostimulation using beta-CaSiO3/beta-Ca-3(PO4)(2) composite bioceramics

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ACTA BIOMATERIALIA (2012)

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Meeting Abstract Endocrinology & Metabolism

Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on Oncostatin M signaling

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BONE (2012)

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3D-printing of highly uniform CaSiO3 ceramic scaffolds: preparation, characterization and in vivo osteogenesis

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Micro-/Nano-sized hydroxyapatite directs differentiation of rat bone marrow derived mesenchymal stem cells towards an osteoblast lineage

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NANOSCALE (2012)

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Direct ink writing of highly porous and strong glass scaffolds for load-bearing bone defects repair and regeneration

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ACTA BIOMATERIALIA (2011)

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Immune responses to implants - A review of the implications for the design of immunomodulatory biomaterials

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BMP-9 Induced Osteogenic Differentiation of Mesenchymal Stem Cells: Molecular Mechanism and Therapeutic Potential

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CURRENT GENE THERAPY (2011)

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Engineering porous scaffolds using gas-based techniques

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CURRENT OPINION IN BIOTECHNOLOGY (2011)

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Inkjet printing ceramics: From drops to solid

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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY (2011)

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Genetic Demonstration of a Redundant Role of Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Mitogen-Activated Protein Kinases in Promoting Fibroblast Proliferation

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Fabrication of highly porous tissue-engineering scaffolds using selective spherical porogens

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Degradation and biocompatibility of porous nano-hydroxyapatite/polyurethane composite scaffold for bone tissue engineering

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APPLIED SURFACE SCIENCE (2009)

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Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

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CURRENT OPINION IN CELL BIOLOGY (2009)

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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2008)

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Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD

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Quantification of susceptibility artifacts produced on high-field magnetic resonance images by various biomaterials used for neurosurgical implants - Technical note

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Mechanism and application of 3D-printed degradable bioceramic scaffolds for bone repair

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