期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 466, 期 -, 页码 154-159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2014.11.015
关键词
Baicalin; Nanostructured lipid carriers; Uniform design; Bioavailability; Pharmacokinetics
资金
- China-Australia Centre for Health Sciences Research of Shandong University, China [2014GJ09]
- Natural Science Foundation of Shandong Province, China [ZR2011 HM026]
The present study aimed to develop a novel baicalin-loaded nanostructured lipid carrier (BA-NLC) system for oral delivery to enhance the bioavailability. BA-NLC were prepared by emulsion-evaporation and low temperature-solidification technique and optimized by a five-factor four-level uniform design. The characteristics of BA-NLC including morphology, particle size, zeta potential, entrapment efficiency and drug loading were investigated. The results showed that the optimized BA-NLC was nearly spherical in shape with a mean diameter of 244.7 nm. The entrapment efficiency and drug loading were 59.51 +/- 0.57% and 3.54 perpendicular to 0.11%, respectively. In vitro drug release revealed a pattern with burst release initially and sustained release afterwards for BA-NLC. Moreover, BA-NLC exhibited prolonged MRT and increased AUC compared to pure BA. All the detailed evidence indicated that BA-NLC could be a potential delivery system for the oral administration of BA. (C) 2014 Elsevier B.V. All rights reserved.
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