期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ijms242015375
关键词
Dendrobium officinale; phenanthrene; 1,5,6-trimethoxy-2,7-dihydroxyphenanthrene; P53; cytotoxic
In this study, 12 phenanthrene compounds were extracted and isolated from Dendrobium officinale, and their cytotoxic activities against cancer cells were evaluated. Compound 5 showed significant cytotoxic effects and could be a potential drug candidate for cervical cancer treatment.
Natural products are irreplaceable reservoirs for cancer treatments. In this study, 12 phenanthrene compounds were extracted and isolated from Dendrobium officinale. Each chemical structure was identified using comprehensive NMR analysis. All compounds were evaluated for their cytotoxic activities against five tumor cell lines, i.e., HeLa, MCF-7, SK-N-AS, Capan-2 and Hep G2. Compound 5, 1,5,6-trimethoxy-2,7-dihydroxyphenanthrene, displayed the most significant cytotoxic effect against HeLa and Hep G2 cells, with an IC50 of 0.42 and 0.20 mu M. For Hela cells, further experiments demonstrated that compound 5 could obviously inhibit cell migration, block cell cycle in the G0/G1 phase and induce apoptosis. Expression measurements for p53 indicated that knock down of p53 by siRNA could mitigate the apoptosis induced by compound 5. Therefore, the compound 5 is a potential candidate drug for HeLa cells in cervical cancer.
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