Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma

Article Multidisciplinary Sciences

The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma

Cunjie Chang et al.

Summary: In this study, the authors investigate the role of the splice variant of SREK1 and its upstream regulator SRSF10 in sustaining the oncogenic signal in hepatocarcinogenesis.

NATURE COMMUNICATIONS (2022)

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Review Gastroenterology & Hepatology

Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies

Xinjun Lu et al.

Summary: Primary liver cancers, including HCC and iCCA, are highly lethal tumors with limited treatment options. The mTOR complex is a central regulator of cell growth and metabolism and plays a key role in liver-tumor development and progression. Current research aims to develop more effective mTOR inhibitors for liver-cancer treatment.

HEPATOLOGY (2021)

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Article Chemistry, Multidisciplinary

ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/beta-catenin signaling pathway

Liang-yun Li et al.

Summary: ZEB1 plays a crucial role in hepatocellular carcinoma (HCC) by promoting cell proliferation, migration, and invasion through activating the Wnt/β-catenin signaling pathway. Meanwhile, miR-708 inhibits the growth and metastasis of HCC cells by targeting ZEB1.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Pharmacology & Pharmacy

Eg5 targeting agents: From new anti-mitotic based inhibitor discovery to cancer therapy and resistance

Isabel Garcia-Saez et al.

Summary: Eg5, a motor protein involved in mitotic spindle formation, has attracted interest as a potential target for cancer chemotherapy. While most inhibitors have shown limited efficacy, one inhibitor, Arry-520, has demonstrated clinical effectiveness in multiple myeloma patients and sparked new research trends including alternative binding sites and drug synergy. The field faces challenges in drug resistance development and improving therapeutic applications for Eg5 inhibitors.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Medicine, Research & Experimental

Cytokinesis regulators as potential diagnostic and therapeutic biomarkers for human hepatocellular carcinoma

Yiting Qiao et al.

Summary: The article summarizes the importance of cytokinesis in maintaining cell ploidy level and its critical role in human hepatocellular carcinoma, including inducing abnormal cell ploidy and being potential therapeutic targets.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

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Article Cell Biology

Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells

Yu-Peng Wu et al.

Summary: KIF18B, an ATPase involved in cell division, is overexpressed in prostate cancer (PCa) and associated with poorer disease-free survival. Its overexpression promotes proliferation, migration, and invasion of PCa cells while inhibiting apoptosis. Additionally, KIF18B activates the PI3K-AKT-mTOR signaling pathway in PCa, suggesting its potential as a novel biomarker.

CELL DEATH & DISEASE (2021)

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Article Biochemistry & Molecular Biology

KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma

Meng-jun Qiu et al.

Summary: The tumor microenvironment plays a crucial role in tumor progression, recurrence, and immunotherapy outcomes. KIF18B has been identified as a core gene in hepatocellular carcinoma microenvironment with significant associations with immune cell subtypes and tumor cell stemness. Upregulation of KIF18B is linked to poor clinical characteristics and outcomes, while downregulation inhibits proliferation of liver cancer cells.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

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Article Oncology

Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma

Qing Li et al.

CANCER LETTERS (2020)

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Review Cell Biology

Lysosomes as dynamic regulators of cell and organismal homeostasis

Andrea Ballabio et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma

Gustavo Ferrin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

KIF18B promotes hepatocellular carcinoma progression through activating Wnt/β-catenin-signaling pathway

Bin Yang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Cell Biology

KIF18B promotes the proliferation of pancreatic ductal adenocarcinoma via activating the expression of CDCA8

Baoyu Li et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Surgery

mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors

Andreas A. Schnitzbauer et al.

ANNALS OF SURGERY (2020)

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Article Oncology

Kinesin Superfamily Member 18B (KIF 18B) Promotes Cell Proliferation in Colon Adenocarcinoma

Fei Zhao et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Oncology

KIF18B promotes tumor progression in osteosarcoma by activating β-catenin

Tian Gao et al.

CANCER BIOLOGY & MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

RRAD suppresses the Warburg effect by downregulating ACTG1 in hepatocellular carcinoma

Yingcai Yan et al.

ONCOTARGETS AND THERAPY (2019)

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Review Biochemistry & Molecular Biology

Targeting the mTOR regulatory network in hepatocellular carcinoma: Are we making headway?

Xiang-Nan Yu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Anatomy & Morphology

KIF18B as a regulator in microtubule movement accelerates tumor progression and triggers poor outcome in lung adenocarcinoma

Ze Ji et al.

TISSUE & CELL (2019)

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Review Biochemistry & Molecular Biology

Kinesin superfamily: roles in breast cancer, patient prognosis and therapeutics

A. J. Lucanus et al.

ONCOGENE (2018)

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Article Cell Biology

Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning

Toni McHugh et al.

JOURNAL OF CELL BIOLOGY (2018)

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Review Cell Biology

Mechanisms of lysosomal positioning and movement

Birol Cabukusta et al.

TRAFFIC (2018)

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Article Biotechnology & Applied Microbiology

KIF18B promotes tumor progression through activating the Wnt/β-catenin pathway in cervical cancer

Yaqin Wu et al.

ONCOTARGETS AND THERAPY (2018)

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Review Oncology

Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation

Roy G. H. P. van Heesbeen et al.

CHROMOSOMA (2017)

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Review Biochemistry & Molecular Biology

mTORC1 and mTORC2 in cancer and the tumor microenvironment

L. C. Kim et al.

ONCOGENE (2017)

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Article Oncology

A Phase 1 and 2 Study of Filanesib Alone and in Combination With Low-Dose Dexamethasone in Relapsed/Refractory Multiple Myeloma

Jatin J. Shah et al.

CANCER (2017)

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Review Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton et al.

CELL (2017)

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Article Gastroenterology & Hepatology

The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway

Jianxiang Chen et al.

GUT (2016)

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Article Cell Biology

Spatial regulation of astral microtubule dynamics by Kif18B in PtK cells

Claire E. Walczak et al.

MOLECULAR BIOLOGY OF THE CELL (2016)

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Article Gastroenterology & Hepatology

ECT2 regulates the Rho/ERK signalling axis to promote early recurrence in human hepatocellular carcinoma

Jianxiang Chen et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Gastroenterology & Hepatology

Emerging Trends in Hepatocellular Carcinoma Incidence and Mortality

Basile Njei et al.

HEPATOLOGY (2015)

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Review Gastroenterology & Hepatology

Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends

Matthias S. Matter et al.

JOURNAL OF HEPATOLOGY (2014)

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Review Oncology

Oncogenic role of kinesin proteins and targeting kinesin therapy

Xinran Liu et al.

CANCER SCIENCE (2013)

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Article Biochemistry & Molecular Biology

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Katy J. Petherick et al.

EMBO JOURNAL (2013)

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Article Biochemistry & Molecular Biology

A Complex of Kit18b and MCAK Promotes Microtubule Depolymerization and Is Negatively Regulated by Aurora Kinases

Marvin E. Tanenbaum et al.

CURRENT BIOLOGY (2011)

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Article Biochemistry & Molecular Biology

γ-Actin regulates cell migration and modulates the ROCK signaling pathway

Michael S. Y. Shum et al.

FASEB JOURNAL (2011)

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Article Cell Biology

Lysosomal positioning coordinates cellular nutrient responses

Viktor I. Korolchuk et al.

NATURE CELL BIOLOGY (2011)

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Article Cell Biology

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

Liang Qin et al.

AUTOPHAGY (2010)

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Review Cell Biology

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Paul Saftig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

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Article Multidisciplinary Sciences

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Yasemin Sancak et al.

SCIENCE (2008)

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Review Cell Biology

Analysis of the kinesin superfamily: insights into structure and function

H Miki et al.

TRENDS IN CELL BIOLOGY (2005)

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Review Cell Biology

Secretory lysosomes

EJ Blott et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

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Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma

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