Organophosphorus compounds containing stable C(sp(3))- and C(sp(2))-P bonds have various applications, but current cross-coupling methods require unsustainable solvents. This study presents a novel strategy for performing C(sp(2))-P cross-coupling reactions in aqueous micelles, allowing for mild and environmentally friendly conditions.
Organophosphorus compounds containing hydrolytically and metabolically stable C(sp(3))- and C(sp(2))-P bonds are widely used as reagents, ligands, pesticides, herbicides, flame retardants, surface modifiers, and antiviral and anticancer drugs. These applications rely on efficient C(sp(3))- and C(sp(2))-P bond-forming reactions. However, currently available C(sp(2))-P cross-coupling protocols require high catalyst loadings and temperatures, as well as environmentally unsustainable and harmful organic solvents (e.g., N,N-dimethylformamide, DMF). Herein, we disclose a conceptually novel strategy for performing multimetallic Pd/Ni- and dual-ligand Pd-catalyzed C(sp(2))-P cross-coupling reactions in aqueous micelles under mild and environmentally friendly conditions. Micellar catalysis in water enables C(sp(2))-P cross-coupling while avoiding environmentally unsustainable organic solvents, thereby reducing organic waste generation. Such micellar C(sp(2))-P cross-coupling reactions tolerate various functional groups and provide access to structurally diverse (hetero)aryl (thio)phosphonates, phosphinates and phosphine oxides using inexpensive commercial materials and catalysts. Moreover, C(sp(2))-P cross-coupling reactions of medically relevant substrates and drugs under late-stage functionalization settings and multistep one-pot processes highlight the potential applications of this experimental paradigm.
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