4.7 Article

Intergenerational effects on fertility in male and female mice after chronic exposure to environmental doses of NSAIDs and 17α-ethinylestradiol mixtures

期刊

FOOD AND CHEMICAL TOXICOLOGY
卷 182, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2023.114085

关键词

NSAIDs; EE2; Environmental doses; Fertility; Testis; Ovary; Mice; Gonad transcriptome

向作者/读者索取更多资源

This study investigated the adverse effects of NSAIDs and EE2 mixtures on the reproductive organ development and fertility in mice. The results showed that exposure to these mixtures altered reproductive organ maturation, estrous cyclicity, and spermiogenesis in mice. Transcriptomic analysis revealed changes in gene expression patterns and associated pathways. These findings are important for understanding the adverse effects of these pharmaceuticals on reproductive health.
Non-steroidal anti-inflammatory drugs (NSAIDs) and 17 alpha-ethinylestradiol (EE2) are extensively used in human and veterinary medicine. Due to their partial removal by wastewater treatment plants, they are frequent envi-ronmental contaminants, particularly in drinking water. Here, we investigated the adverse outcomes of chronic exposure to mixtures of NSAIDs (ibuprofen, 2hydroxy-ibuprofen, diclofenac) and EE2 at two environmentally relevant doses in drinking water, on the reproductive organ development and fertility in F1-exposed male and female mice and in their F2 offspring. In male and female F1 mice, which were exposed to these mixtures, reproductive organ maturation, estrous cyclicity, and spermiogenesis were altered. These defects were observed also in F2 animals, in addition to some specific sperm parameter alterations in F2 males. Transcriptomic analysis revealed significant changes in gene expression patterns and associated pathways implicated in testis and ovarian physiology. Chronic exposure of mice to NSAID and EE2 mixtures at environmental doses intergenerationally affected male and female fertility (i.e. total number of pups and time between litters). Our study provides new insights into the adverse effects of these pharmaceuticals on the reproductive health and will facilitate the implementation of a future regulatory environmental risk assessment of NSAIDs and EE2 for human health.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据