Chrononutrition and metabolic health in children and adolescents: a systematic review and meta-analysis

Context Obesity has emerged as a global health issue for the pediatric population, increasing the need to investigate physiopathological aspects to prevent the appearance of its cardiometabolic complications. Chrononutrition is a field of research in nutritional sciences that investigates the health impact of 3 different dimensions of feeding behavior: regularity of meals, frequency, and timing of food intake.Objective We carried out a systematic review and meta-analysis to investigate the association between chrononutrition in children and adolescents and the risk of overweight/obesity or a cluster of metabolic abnormalities related to glucose and lipid metabolism, blood pressure, and cardiovascular disease risk.Data Extraction A literature search was performed using PubMed, EMBASE, and The Cochrane Library for relevant articles published before August 2022.Data Analysis A total of 64 articles were included in the narrative synthesis (47 cross-sectional and 17 cohort studies), while 16 studies were included in the meta-analysis. Meta-analysis showed that non-daily breakfast consumers (<= 6 d/wk) had a higher risk of overweight/obesity (odds ratio [OR], 1.45; 95% confidence interval [CI], 1.08-1.82] compared with daily breakfast eaters (7 d/wk). Similarly, irregular breakfast consumption (only 0-to-3 times/wk) increased the risk of abdominal obesity (waist-to-height ratio >= 0.5) compared with regular consumption (5-to-7 times/wk) (OR, 1.38; 95% CI, 1.26-1.49). There was evidence to suggest that a regular frequency of meal consumption (>= 4 times/d) is preventive against overweight/obesity development compared with fewer meals (<= 3 times/d) (OR, 0.83; 95% CI, 0.70-0.97). In the narrative synthesis, snacking habits showed controversial results, while food timing was the most understudied dimension.Conclusion Overall, our data indicate a potential implication of chrononutrition in affecting pediatric metabolic health; however, the evidence of this association is limited and heterogeneous. Further prospective and intervention studies with a consistent approach to categorize the exposure are needed to elucidate the importance of chrononutrition for pediatric metabolic health.

Automated summary

The study found that the dietary habits of children and adolescents are associated with overweight/obesity and metabolic abnormalities. Eating breakfast daily can reduce the risk of overweight/obesity, while irregular breakfast consumption increases the risk of abdominal obesity. In addition, a higher frequency of meals is associated with a lower risk of overweight/obesity. Dietary habits and food timing may also affect pediatric metabolic health, but there is limited research in this area.