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Article
Genetics & Heredity
Yiheng Chen et al.
Summary: Through genome-wide association studies, this study identified associations between 690 metabolites and 248 loci, as well as associations between 143 metabolite ratios and 69 loci. The integration of metabolite-gene and gene expression information revealed 94 effector genes for 109 metabolites and 48 metabolite ratios. The use of Mendelian randomization identified 22 metabolites and 20 metabolite ratios with estimated causal effects on 12 traits and diseases.
Article
Multidisciplinary Sciences
Tuo Deng et al.
Nature Communications
(2023)
Review
Chemistry, Multidisciplinary
Yue Wang et al.
Summary: This article describes the basic metabolism in living organisms and the similarities and differences between different species. It discusses the potential and applications of nanozymes in regulating cell metabolism. The regulation of cellular metabolism is of great research significance and has promising applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Santiago Movilla et al.
Summary: The spliceosome machinery catalyzes pre-mRNA splicing with the help of RNA-dependent ATPases/helicases. The ATPase function of Prp2 is activated by RNA binding, which triggers specific interactions and optimally positions the nucleophilic water and general base for ATP hydrolysis. This mechanism is conserved in DExH-box helicases and may be applicable to the entire family.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Toshihiko Katoh et al.
Summary: The BbhII enzyme from Bifidobacterium bifidum is involved in the breakdown of mucin O-glycans, modulating host-microbiota symbiosis and dysbiosis.
NATURE CHEMICAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shi Qiu et al.
Summary: Metabolic abnormalities result in dysfunction of metabolic pathways and the accumulation or deficiency of metabolites, which are hallmarks of diseases. Metabolite signatures closely related to phenotypic information are useful for predicting disease diagnosis, prognosis, and treatment monitoring. Noninvasive diagnosis and monitoring methods with high specificity and selectivity are urgently needed. Small molecule metabolites-based metabolomics has become a specialized tool for the analysis of metabolic biomarkers and pathways, revealing mechanisms of various diseases and therapeutic potential. This review summarizes the potential value of small-molecule candidate metabolites as biomarkers in clinical events, which can improve diagnosis, prognosis, drug screening, and treatment. The challenges to be addressed for future breakthroughs are also discussed.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Friederike Allgower et al.
Summary: Photosystem II (PSII) catalyzes light-driven water oxidization and we found that it uses a redox-triggered proton transfer mechanism for water oxidation. This mechanism resembles functional motifs in other enzymes involved in biological energy conversion, modulating the catalytic barriers for water oxidation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Ralph J. DeBerardinis et al.
Summary: This article reviews recent advancements in metabolic analysis, including small-scale metabolomics techniques, functional screening, and imaging approaches. It discusses the application of metabolomics in genetic and non-genetic disorders, as well as the current challenges and future directions of research.
Article
Chemistry, Multidisciplinary
Liwen Huang et al.
Summary: Research on nano-bio interfaces has shown that 2D nanomaterials can interact with biological membranes to form impactful structures. This interaction can lead to changes in membrane phospholipids, potentially alleviating neurodegenerative disorders. In this study, PEGylated 2D nanomaterials were found to alleviate behavioral and neuronal degeneration in Parkinson's disease. The interaction between these nanomaterials and phosphatidylinositol-4,5-bisphosphate was identified, and the underlying mechanism was revealed to involve a shift in the orientation of the lipid within the membrane, preventing cleavage-mediated inositol 1,4,5-trisphosphate and reducing endoplasmic reticulum stress. These findings suggest that P-sheet nanomaterials could be a drug-free treatment option for neurodegenerative disorders.
Article
Chemistry, Multidisciplinary
Yue Liao et al.
Summary: Cellular metabolism uses compartmentalized multienzyme efficient catalysis to realize substance metabolism, energy conversion and immune defenses. This study presents a convenient method of self-anchoring multienzymes within cell-like hydrogels using enzyme-initiated radical polymerization, resulting in higher activity, stability and recyclability compared to free enzymes.
SCIENCE CHINA-CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Xia Wang et al.
Summary: Enzymes play a vital role in catalyzing cellular reactions within metabolic pathways. Hydrogels, as highly hydrated polymer materials, are considered ideal for matching the properties of the natural extracellular matrix (ECM) and confining bioactive guests such as enzymes for efficient cascade catalysis. The development of enzyme-laden bioactive hydrogels has shown promise in biomedical tissue engineering, biocatalytic health monitoring, and therapeutic research.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Jiahui He et al.
Summary: A series of injectable pH-responsive self-healing adhesive hydrogels have been developed for treating gastric bleeding and wound healing after endoscopic treatment. These hydrogels show great potential as endoscopic sprayable bioadhesive materials, with good hemostatic properties and enhanced wound healing effects in animal models.
NANO-MICRO LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Chu Wu et al.
Summary: This study presents an efficient multi-pathway singlet oxygen (O-1(2)) generation system for superactive biocatalytic tumor therapy, utilizing compartmental hierarchical nanoreactors. The system achieves increased efficacy by enhancing direct substrate diffusion and reducing external diffusion, showing outstanding capability for O-1(2) production. Both in vitro and in vivo studies demonstrate the synergetic O-1(2)-mediated inhibition of tumor proliferation, showcasing great potential for the treatment of hypoxic tumors.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Qi Zhang et al.
Summary: The article discusses a new method for achieving fast gelation through enzyme-catalyzed polymerization, which leads to rapid enhancement of soft tissues through the production of carbon radicals and macromolecules, demonstrating the promoting capacity of cartilage regeneration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Mehak Jain et al.
Summary: This study demonstrates that hydrogels can be transformed into self-regulating materials by introducing specific substances, resulting in feedback generation in response to external stimuli. The responsive behavior is driven by interactions between specific enzyme-fuel couples, and can be controlled by varying the concentration of added reduction fuel.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Oncology
Gabriele Bergers et al.
Summary: This review discusses the metabolic rewiring in cancer cells during the metastatic cascade and the distinct metabolic features of primary tumors and metastases. Metastasis is the leading cause of death in most cancer patients, and targeting metastatic seeding and colonization remains a significant challenge. Adjusting metabolism may provide therapeutic opportunities to prevent or reduce metastasis, and targeting the new metabolic traits in established metastases could lead to their eradication.
NATURE REVIEWS CANCER
(2021)
Review
Chemistry, Multidisciplinary
Jenny Z. Zhang et al.
NATURE REVIEWS CHEMISTRY
(2020)
Review
Chemistry, Physical
Margarita Vazquez-Gonzalez et al.
Article
Chemistry, Multidisciplinary
Yinghui Shang et al.
ADVANCED MATERIALS
(2020)
Editorial Material
Multidisciplinary Sciences
Adam Nelson
Article
Multidisciplinary Sciences
Wei Kang et al.
NATURE COMMUNICATIONS
(2019)
Review
Chemistry, Multidisciplinary
Xia Wang et al.
ADVANCED MATERIALS
(2018)
Review
Biochemistry & Molecular Biology
Lianet Noda-Garcia et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87
(2018)
Review
Multidisciplinary Sciences
Lee J. Sweetlove et al.
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Harry G. Saavedra et al.
Article
Multidisciplinary Sciences
Joao P. Pisco et al.
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Hongliang Tan et al.
NATURE COMMUNICATIONS
(2017)
Editorial Material
Microbiology
Jens Nielsen
NATURE MICROBIOLOGY
(2017)
Review
Engineering, Biomedical
Kan Yue et al.
Article
Chemistry, Multidisciplinary
Jennifer L. Furman et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Review
Multidisciplinary Sciences
M Garcia-Viloca et al.
