4.4 Article

Morphinan and isoquinoline alkaloids from the tuberous roots of Stephania cepharantha

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NATURAL PRODUCT RESEARCH
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TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2023.2275740

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Stephania cepharantha; morphinan alkaloids; isoquinoline alkaloids; cytotoxic activities

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A new morphinan alkaloid and a new cularine alkaloid were isolated from the roots of Stephania cepharantha, both of which showed cytotoxic activities against human cancer cell lines. The structures of these compounds were determined by spectroscopic data analyses.
A new morphinan alkaloid (6S, 9S, 13 R, 14S)-6-O-acetyl-7,8-Didehydro-4-hydroxy-3,7-dimethoxymorphinan-6-ol (1), and a new naturally occurring cularine alkaloid (S)-2, 3, 12, 12a-tetrahydro-5, 6, 9, 10-tetramethoxy-1-methyl-1H-[1]benzoxepino[2, 3, 4-ij]isoquinoline(5), along with four known alkaloids were isolated from the roots of Stephania cepharantha. The structures of these compounds were elucidated based on spectroscopic data analyses. Cytotoxic activities of the compounds against three human cancer cell lines (A549, MCF-7 and SW480) were also evaluated.

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